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公开(公告)号：US20160184342A1
公开(公告)日：2016-06-30
申请号：US14903949
申请日：2014-07-08
申请人： GALDERMA S.A.
发明人： Jean JACOVELLA , Jean-Paul CHAPPUIS , Nathalie SORDELLO WAGNER , Alexandre KAOUKHOV , Michael GRAEBER , Laurence SALIN , Michel PONCET , Philippe BRIANTAIS , Khaled BENKALI
IPC分类号： A61K31/7048 , A61K9/00 , A61K47/32 , A61K47/10 , A61K47/26 , A61K47/24 , A61K47/18 , A61K47/14 , A61K47/02 , A61K31/4164 , A61K47/12
CPC分类号： A61K31/7048 , A61K9/0014 , A61K9/06 , A61K31/4164 , A61K31/4174 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/24 , A61K47/26 , A61K47/32 , A61P17/00 , A61P33/14 , A61K2300/00
摘要： Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.
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2.发明申请公开(公告)号：US20130109642A1
公开(公告)日：2013-05-02
申请号：US13716667
申请日：2012-12-17
申请人： Galderma S.A.
IPC分类号： A61K31/7048
CPC分类号： A61K31/7048 , A61K9/0048
摘要： Administration of at least one compound of the family of the avermectins or of the family of the milbemycins, notably ivermectin, is useful for the treatment of ophthalmic pathologies, including ocular rosacea.
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公开(公告)号：US20180264021A1
公开(公告)日：2018-09-20
申请号：US15988368
申请日：2018-05-24
申请人： Galderma S.A.
发明人： Jean JACOVELLA , Jean-Paul CHAPPUIS , Alexandre KAOUKHOV , Michael GRAEBER , Michel PONCET , Philippe BRIANTAIS , Laurence SALIN
IPC分类号： A61K31/7048 , A61K47/24 , A61K9/06 , A61K47/26 , A61K9/00 , A61K31/4164 , A61K47/10 , A61K47/18 , A61K47/12 , A61K47/32 , A61K47/02 , A61K31/4174 , A61K47/14
CPC分类号： A61K31/7048 , A61K9/0014 , A61K9/06 , A61K31/4164 , A61K31/4174 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/24 , A61K47/26 , A61K47/32 , A61P17/00 , A61P33/14 , A61K2300/00
摘要： Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
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公开(公告)号：US20200000835A1
公开(公告)日：2020-01-02
申请号：US16549405
申请日：2019-08-23
申请人： Galderma S.A.
发明人： Jean JACOVELLA , Jean-Paul CHAPPUIS , Nathalie SORDELLO WAGNER , Alexandre KAOUKHOV , Michael GRAEBER , Laurence SALIN , Michel PONCET , Philippe BRIANTAIS , Khaled BENKALI
IPC分类号： A61K31/7048 , A61P33/14 , A61P17/00 , A61K47/10 , A61K47/14 , A61K9/06 , A61K31/4174 , A61K9/00 , A61K31/4164 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/24 , A61K47/26 , A61K47/32
摘要： Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.
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公开(公告)号：US20180207188A1
公开(公告)日：2018-07-26
申请号：US15909090
申请日：2018-03-01
申请人： Galderma S.A.
发明人： Jean JACOVELLA , Jean-Paul CHAPPUIS , Alexandre KAOUKHOV , Michael GRAEBER , Michel PONCET , Philippe BRIANTAIS , Laurence SALIN
IPC分类号： A61K31/7048 , A61K31/4174 , A61K47/02 , A61K47/32 , A61K47/12 , A61K47/18 , A61K47/24 , A61K47/14 , A61K47/10 , A61K31/4164 , A61K9/00 , A61K47/26 , A61K9/06
CPC分类号： A61K31/7048 , A61K9/0014 , A61K9/06 , A61K31/4164 , A61K31/4174 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/24 , A61K47/26 , A61K47/32 , A61P17/00 , A61P33/14 , A61K2300/00
摘要： Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
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公开(公告)号：US20180177813A1
公开(公告)日：2018-06-28
申请号：US15902109
申请日：2018-02-22
申请人： Galderma S.A.
发明人： Jean JACOVELLA , Jean-Paul CHAPPUIS , Nathalie SORDELLO WAGNER , Alexandre KAOUKHOV , Michael GRAEBER , Laurence SALIN , Michel PONCET , Philippe BRIANTAIS , Khaled BENKALI
IPC分类号： A61K31/7048 , A61K31/4174 , A61K47/02 , A61K47/32 , A61K47/12 , A61K47/18 , A61K47/24 , A61K47/14 , A61K47/10 , A61K31/4164 , A61K9/00 , A61K47/26 , A61K9/06
CPC分类号： A61K31/7048 , A61K9/0014 , A61K9/06 , A61K31/4164 , A61K31/4174 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/24 , A61K47/26 , A61K47/32 , A61P17/00 , A61P33/14 , A61K2300/00
摘要： Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.
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公开(公告)号：US20160158263A1
公开(公告)日：2016-06-09
申请号：US14903906
申请日：2014-07-08
申请人： GALDERMA S.A.
发明人： Jean JACOVELLA , Jian-Paul CHAPPUIS , Alexandre KAOUKHOV , Michael GRAEBER , Laurence SALIN , Michel PONCET , Philippe BRIANTAIS
IPC分类号： A61K31/7048 , A61K31/4164 , A61K9/00
CPC分类号： A61K31/7048 , A61K9/0014 , A61K9/06 , A61K31/4164 , A61K47/10 , A61K47/14 , A61K2300/00
摘要： Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
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8.发明申请ADMINISTRATION OF AVERMECTIN/MILBEMYCIN COMPOUNDS FOR THE TREATMENT OF OPHTHALMIC PATHOLOGIES 有权用于治疗眼底病的AVEMECTIN / MILBEMYCIN化合物的治疗公开(公告)号：US20140256662A1
公开(公告)日：2014-09-11
申请号：US14284524
申请日：2014-05-22
申请人： Galderma S.A.
IPC分类号： A61K31/7048 , A61K9/00
CPC分类号： A61K31/7048 , A61K9/0048
摘要： Administration of at least one compound of the family of the avermectins or of the family of the milbemycins, notably ivermectin, is useful for the treatment of ophthalmic pathologies, including ocular rosacea.
摘要翻译： 至少一种阿维菌素家族或米尔倍霉菌家族中的至少一种化合物，特别是伊维菌素，可用于治疗眼科病症，包括眼酒渣石。
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公开(公告)号：US20210177882A1
公开(公告)日：2021-06-17
申请号：US17178542
申请日：2021-02-18
申请人： Galderma S.A.
发明人： Jean JACOVELLA , Jean-Paul CHAPPUIS , Nathalie SORDELLO WAGNER , Alexandre KAOUKHOV , Michael GRAEBER , Laurence SALIN , Michel PONCET , Philippe BRIANTAIS , Khaled BENKALI
IPC分类号： A61K31/7048 , A61P33/14 , A61P17/00 , A61K47/10 , A61K47/14 , A61K9/06 , A61K31/4174 , A61K9/00 , A61K31/4164 , A61K47/02 , A61K47/12 , A61K47/24 , A61K47/26 , A61K47/32
摘要： Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.
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公开(公告)号：US20160175337A1
公开(公告)日：2016-06-23
申请号：US14973037
申请日：2015-12-17
申请人： Galderma S.A.
发明人： Jean JACOVELLA , Jean-Paul CHAPPUIS , Alexandre KAOUKHOV , Michael GRAEBER , Michel PONCET , Philippe BRIANTAIS , Laurence SALIN
IPC分类号： A61K31/7048 , A61K31/4174
CPC分类号： A61K31/7048 , A61K9/0014 , A61K9/06 , A61K31/4164 , A61K31/4174 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/24 , A61K47/26 , A61K47/32 , A61P17/00 , A61P33/14 , A61K2300/00
摘要： Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
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