公开(公告)号：US11116811B2

公开(公告)日：2021-09-14

申请号：US16745690

申请日：2020-01-17

申请人： Galderma S.A.

发明人： Laurent Chantalat ,  Philippe Andres

IPC分类号： A61K36/19 ,  A61K36/48 ,  A61K8/49 ,  A61K8/97 ,  A61K9/00 ,  A61Q19/08 ,  A61K36/70 ,  A61K36/315 ,  A61K9/06 ,  A61K31/404 ,  A61K31/519

摘要： A refined Indigo Naturalis extract or Indigo-producing plant extract containing at least 65% (w/w) an indirubin derivative based on total weight of active ingredients is described. Also described are a pharmaceutical composition containing the refined extract, and the use of the pharmaceutical composition for treating or alleviating a disease or condition.

公开(公告)号：US10940271B2

公开(公告)日：2021-03-09

申请号：US16087850

申请日：2017-03-31

申请人： GALDERMA S.A.

发明人： Anders Holmqvist

IPC分类号： A61M5/315 ,  A61M5/31

摘要： The present specification relates to a syringe comprising a barrel, a plunger moveably arranged within the barrel and a plunger rod for driving the plunger, and a mechanism for providing feedback to a user as the plunger rod is moved relative to the barrel for driving said plunger such that feedback is given to a user as the plunger rod is moved relative to the barrel for driving the plunger. The plunger rod is arranged to drive the plunger such that a predetermined relative movement between at least a portion of the plunger rod and the plunger is allowed. The present specification further relates to a plunger assembly wherein a predetermined relative movement between at least a portion of the plunger rod and the plunger is allowed.

公开(公告)号：US10745493B2

公开(公告)日：2020-08-18

申请号：US15540461

申请日：2015-12-29

申请人： Galderma S.A.

发明人： Kristoffer Bergman

IPC分类号： C08B37/08 ,  C08B37/02 ,  C08B37/00 ,  C08G81/00 ,  A61K8/91 ,  A61K8/73 ,  A61Q19/08 ,  A61Q19/00 ,  A61L27/20

摘要： A graft copolymer comprising: a core polymer comprising a crosslinked or non-crosslinked polysaccharide, a plurality of primary graft polymers covalently grafted to the core polymer, a plurality of secondary graft polymers covalently grafted to each primary graft polymer, an injectable dermal aesthetic formulation comprising such a graft copolymer and a method of preparing such a graft copolymer.

公开(公告)号：US20200247913A1

公开(公告)日：2020-08-06

申请号：US16781264

申请日：2020-02-04

申请人： Galderma S.A.

发明人： Morgan Karlsson ,  Anne Helander Kenne ,  Åke Öhrlund

IPC分类号： C08B37/08 ,  D01F9/00 ,  A61Q19/00 ,  A61K31/728 ,  A61K9/00 ,  A61K8/73 ,  A61K8/04 ,  A61Q19/08

摘要： A method for manufacturing a shaped cross-linked hyaluronic acid product including the step of subjecting a non-cross-linked precipitated hyaluronic acid substrate in a desired shape to a single cross-linking reaction in a liquid medium having a pH of 11.5 or higher and including one or more polyfunctional cross-linking agent(s) and an amount of one or more organic solvent(s) giving precipitating conditions for hyaluronic acid, under suitable conditions to obtain a precipitated, shaped cross-linked hyaluronic acid product having a degree of modification of 1-40 cross-linking agent units per 1000 disaccharide units.

公开(公告)号：US10695391B2

公开(公告)日：2020-06-30

申请号：US16367405

申请日：2019-03-28

申请人： Galderma S.A.

发明人： Yin-Ku Lin ,  Isabelle Cardinaud ,  Philippe Andres ,  Laurent Chantalat ,  Jean-Thomas Pierson ,  Antoine Bily ,  Loïc Le Bronec

IPC分类号： A61K36/00 ,  A61K36/70 ,  A61K36/19 ,  A61K36/315 ,  A61K36/48 ,  A61K31/404

摘要： The present invention relates to a process for preparing an extract from one or more botanical raw materials, such as Indigo Naturalis and the extract itself. The present invention also relates to a composition comprising the extract, as well as the use of composition in medical or cosmetic applications.

公开(公告)号：US10555985B2

公开(公告)日：2020-02-11

申请号：US16261773

申请日：2019-01-30

申请人： Galderma S.A.

发明人： Laurent Chantalat ,  Philippe Andres

IPC分类号： A61K36/70 ,  A61K36/19 ,  A61K36/315 ,  A61K36/48 ,  A61K8/49 ,  A61K8/97 ,  A61K9/00 ,  A61K9/06 ,  A61K31/404 ,  A61K31/519 ,  A61Q19/08

摘要： A refined Indigo Naturalis extract or Indigo-producing plant extract containing at least 65% (w/w) an indirubin derivative based on total weight of active ingredients is described. Also described are a pharmaceutical composition containing the refined extract, and the use of the pharmaceutical composition for treating or alleviating a disease or condition.

公开(公告)号：US20200030219A1

公开(公告)日：2020-01-30

申请号：US16066985

申请日：2016-12-28

申请人： GALDERMA S.A.

发明人： Johan OLSSON ,  Craig Steven HARRIS

IPC分类号： A61K8/73 ,  A61K8/04 ,  A61Q19/00 ,  C08J3/075 ,  C08J7/14 ,  C08J3/24 ,  C08B37/00 ,  C08B37/08

摘要： A method of preparing a hydrogel product including crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include residual amine groups; and ii) acylating residual amine groups of the crosslinked glycosaminoglycans provided in i) to form acylated crosslinked glycosaminoglycans.

公开(公告)号：US10232006B2

公开(公告)日：2019-03-19

申请号：US15592911

申请日：2017-05-11

申请人： Galderma S.A.

发明人： Laurent Chantalat ,  Philippe Andres

IPC分类号： A61K36/70 ,  A61K36/19 ,  A61K36/315 ,  A61K36/48 ,  A61K8/49 ,  A61K8/97 ,  A61K9/00 ,  A61K9/06 ,  A61K31/404 ,  A61K31/519 ,  A61Q19/08

摘要： A refined Indigo Naturalis extract or Indigo-producing plant extract containing at least 65% (w/w) an indirubin derivative based on total weight of active ingredients is described. Also described are a pharmaceutical composition containing the refined extract, and the use of the pharmaceutical composition for treating or alleviating a disease or condition.

公开(公告)号：US20180264021A1

公开(公告)日：2018-09-20

申请号：US15988368

申请日：2018-05-24

申请人： Galderma S.A.

发明人： Jean JACOVELLA ,  Jean-Paul CHAPPUIS ,  Alexandre KAOUKHOV ,  Michael GRAEBER ,  Michel PONCET ,  Philippe BRIANTAIS ,  Laurence SALIN

IPC分类号： A61K31/7048 ,  A61K47/24 ,  A61K9/06 ,  A61K47/26 ,  A61K9/00 ,  A61K31/4164 ,  A61K47/10 ,  A61K47/18 ,  A61K47/12 ,  A61K47/32 ,  A61K47/02 ,  A61K31/4174 ,  A61K47/14

CPC分类号： A61K31/7048 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/4164 ,  A61K31/4174 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/183 ,  A61K47/24 ,  A61K47/26 ,  A61K47/32 ,  A61P17/00 ,  A61P33/14 ,  A61K2300/00

摘要： Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.

公开(公告)号：US10039770B2

公开(公告)日：2018-08-07

申请号：US15021789

申请日：2014-09-26

申请人： Galderma S.A.

发明人： Warren J. Scherer

IPC分类号： A61K9/127 ,  A61K31/5575 ,  A61K45/06 ,  A61K9/00

摘要： A method of treating atrophic cutaneous scarring in humans is claimed. The method involves the topical application of a therapeutic amount of prostaglandin F2-alpha (PGF 2α) or a PGF 2α analog directly to the area of atrophic scarring.