公开(公告)号：US20170010264A1

公开(公告)日：2017-01-12

申请号：US15270848

申请日：2016-09-20

申请人： Gale W. NEWMAN ,  Sam ANYANWU

发明人： Gale W. NEWMAN ,  Sam ANYANWU

IPC分类号： G01N33/569 ,  C12Q1/70

CPC分类号： G01N33/56988 ,  C12Q1/70 ,  C12Q1/703 ,  C12Q1/706 ,  C12Q1/707 ,  G01N1/40 ,  G01N33/493 ,  G01N33/56983 ,  G01N33/576 ,  G01N33/6893 ,  G01N2333/02 ,  G01N2333/10 ,  G01N2333/161 ,  G01N2333/162 ,  G01N2333/163 ,  G01N2333/186 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56 ,  Y02A50/54

摘要： A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers present on exosomes in a bodily fluid sample from the subject is disclosed. Also disclosed are a method for monitoring the course of a hepatitis virus infection or a hepatitis disease condition in a subject and a method for monitoring effectiveness of treatment to a subject with an anti-hepatitis virus agent based on hepatitis virus-associated biomarkers present on exosomes in bodily fluid samples from the subject, as well as a kit for diagnosing hepatitis virus infection and/or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers on exosomes in bodily fluid samples from the subject.

摘要翻译： 公开了一种用于诊断受试者中基于肝炎病毒相关生物标志物的肝炎病毒感染或肝炎病症的方法，所述肝炎病毒相关生物标志物存在于来自受试者的体液样品中的外来体上。 还公开了一种用于监测受试者中肝炎病毒感染或肝炎疾病状况的过程的方法以及基于存在于外来体上的肝炎病毒相关生物标志物来监测具有抗肝炎病毒剂的受试者治疗有效性的方法 来自受试者的体液样本，以及用于诊断受试者中基于肝炎病毒相关生物标志物的肝炎病毒感染和/或肝炎疾病状况的试剂盒，其来自受试者的体液样品中的外来体。