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公开(公告)号：US11577082B2
公开(公告)日：2023-02-14
申请号：US16347940
申请日：2017-11-08
Applicant: Galvani Bioelectronics Limited , Université Côte d'Azur , Centre Nationale de La Recherche Scientifique
Inventor： Philippe Blancou , Nicolas Glaichenhaus , Arun Sridhar
Abstract: Devices and methods for the stimulation of neural signaling of an apical splenic nerve, the device having a transducer for placement on or around the apical splenic nerve, and a signal generator to generate a signal that stimulates or inhibits the neural activity of the apical splenic nerve to produce a physiological response. The transducer has at least one electrode, and the signal generator is a voltage or current source. The stimulation electrical signal has a frequency of between 1 Hz and 50 Hz.
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公开(公告)号：US20250082937A1
公开(公告)日：2025-03-13
申请号：US18791161
申请日：2024-07-31
Inventor： Alessandra Giarola , Yee-Hsee Hsieh , Stephen J. Lewis , Arun Sridhar
Abstract: This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.
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公开(公告)号：US11571574B2
公开(公告)日：2023-02-07
申请号：US16348924
申请日：2017-11-10
Inventor： Hans Jakob Kristoffer Famm , Harumi Hotta , Arun Sridhar
Abstract: Modulation of neural activity in the superior laryngeal nerve (SLN) or cervical sympathetic trunk (CST) is effective in treating diseases and conditions mediated by thyroid and parathyroid hormones, in particular diseases associated with calcitonin secretion (e.g. osteoporosis) or diseases associated with thyroxine secretion (e.g. hypothyroid syndrome).
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公开(公告)号：US20230018108A1
公开(公告)日：2023-01-19
申请号：US17893924
申请日：2022-08-23
Applicant: Galvani Bioelectronics Limited
Inventor： Gerald Edwin Hunsberger , Arun Sridhar
Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.
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公开(公告)号：US20230017399A1
公开(公告)日：2023-01-19
申请号：US17883332
申请日：2022-08-08
Inventor： Alessandra Giarola , Yee-Hsee Hsieh , Stephen J. Lewis , Arun Sridhar
Abstract: This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.
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Patent Agency Ranking
公开(公告)号：US10960209B2
公开(公告)日：2021-03-30
申请号：US16320288
申请日：2017-07-25
Inventor： Arun Sridhar , Corey Smith , Kyle Wolf , Georgy Zarkua , Shyue-An Chan
Abstract: Modulation of neural signaling of a branch of the GSN supplying the adrenal gland can regulate the secretion of signaling molecules from the adrenal medulla. In particular, epinephrine, norepinephrine and enkephalin release can be independently regulated.
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公开(公告)号：US20200086109A1
公开(公告)日：2020-03-19
申请号：US16471473
申请日：2017-12-20
Inventor： Arun Sridhar , Alessandra Giarrola , Stephen J. Lewis
Abstract: A neuromodulation apparatus for stimulating neural activity in a renal nerve of a patient is provided, the apparatus comprising a transducer Patient for applying a signal to the renal nerve so as to produce a physiological response. Methods of treating sleep apnoea are also provided, including methods using the neuromodulation apparatus.
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公开(公告)号：US10406362B2
公开(公告)日：2019-09-10
申请号：US15551592
申请日：2016-02-19
Applicant: GALVANI BIOELECTRONICS LIMITED , HUNTINGTON MEDICAL RESEARCH INSTITUTES , UNIVERSITY OF CHILE
Inventor： Hans Jakob Kristoffer Famm , Hernan E. Lara , Victor Eugene Pikov , Arun Sridhar
Abstract: Methods for treating polycystic ovarian syndrome with a neuromodulation device that modulates sympathetic neural activity are described herein. The neuromodulation device is an apparatus for the treatment of polycystic ovarian syndrome. In one aspect, the apparatus decreases the neural activity of a postganglionic ovary-innervating sympathetic nerve. Modulation in neural activity may be achieved using an apparatus comprising one or more stimulators each configured to apply a signal to a postganglionic ovary-innervating sympathetic nerve of the patient, a controller coupled to the one or more stimulators, the controller controlling the signal to be applied by each of the one or more stimulators, such that the signal decreases the neural activity of the nerve to produce a physiological and/or biochemical response in the patient, wherein the physiological and/or biochemical response comprises an improvement in one or more symptoms of polycystic ovarian syndrome.
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公开(公告)号：US20250099762A1
公开(公告)日：2025-03-27
申请号：US18924183
申请日：2024-10-23
Applicant: Galvani Bioelectronics Limited
Inventor： Gerald Edwin Hunsberger , Arun Sridhar
Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.
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公开(公告)号：US12083342B2
公开(公告)日：2024-09-10
申请号：US17883332
申请日：2022-08-08
Inventor： Alessandra Giarola , Yee-Hsee Hsieh , Stephen J. Lewis , Arun Sridhar
CPC classification number: A61N1/3611 , A61B5/0826 , A61B5/4818 , A61N1/00 , A61N1/0556 , A61N1/18 , A61N1/36
Abstract: This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.
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