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1.发明申请Addition of glycolysis inhibitor to a pathogen reduction and storage solution 审中-公开将糖酵解抑制剂添加到病原体还原和储存溶液中公开(公告)号：US20040029097A1
公开(公告)日：2004-02-12
申请号：US10417925
申请日：2003-04-16
申请人： Gambro, Inc.
IPC分类号： A01N001/02 , A61K031/70
CPC分类号： A61L2/08 , A61L2/0011 , A61L2/0082 , A61L2/10 , A61L2/16 , A61M1/0272 , A61M1/3681 , A61M1/3683 , A61M2202/0275
摘要： This invention relates to the addition of glycolytic inhibitors to solutions used in the pathogen reduction and subsequent storage of platelets. More particularly, the invention relates to the addition of 2-deoxy-D-glucose and sodium succinate to a platelet pathogen reduction and storage solution.
摘要翻译： 本发明涉及将糖酵解抑制剂加入用于减少血小板的病原体和随后储存的溶液中。 更具体地，本发明涉及向血小板病原体还原和储存溶液中加入2-脱氧-D-葡萄糖和琥珀酸钠。
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2.发明申请Removal of adenine during a process of pathogen reducing blood and blood components 有权在病原体减少血液和血液成分的过程中去除腺嘌呤公开(公告)号：US20030201160A1
公开(公告)日：2003-10-30
申请号：US10423200
申请日：2003-04-24
申请人： Gambro, Inc.
IPC分类号： C07C001/00 , C07C006/00
CPC分类号： A61L2/084 , A01N1/0205 , A01N1/0215 , A01N1/0294 , A01N43/90 , A61K35/18 , A61K41/0019 , A61L2/0005 , A61L2/0011 , A61L2/0082 , A61L2/0088 , A61L2/08 , A61L2/10 , A61L2/16 , A61L2202/22
摘要： The methods of this invention involve preventing the formation of a complex between adenine and riboflavin by reducing the amount of adenine in a solution containing blood or blood components to be pathogen reduced.
摘要翻译： 本发明的方法涉及通过减少含有血液或血液成分的溶液中的腺嘌呤的量减少而防止腺嘌呤和核黄素之间的复合物的形成。
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3.发明申请Solution containing platelet activation inhibitors for pathogen reducing and storing blood platelets 审中-公开含有血小板激活抑制剂的溶液，用于减少和储存血小板的病原体公开(公告)号：US20030215785A1
公开(公告)日：2003-11-20
申请号：US10425282
申请日：2003-04-28
申请人： Gambro, Inc.
IPC分类号： A01N001/02
CPC分类号： A61K31/557 , A01N1/02 , A01N1/0215 , A61K31/352 , A61K31/52 , A61K35/19 , A61L2/0011 , A61L2/0088
摘要： This invention relates to the addition of platelet activation inhibitors to solutions used in the pathogen reduction and subsequent storage of platelets. More particularly, the invention relates to the addition of adenylate cyclase stimulators and phosphodiesterase inhibitors to a platelet pathogen reduction and storage solution.
摘要翻译： 本发明涉及将血小板激活抑制剂添加到用于减少血小板的病原体和随后储存的溶液中。 更具体地，本发明涉及向血小板病原体还原和储存溶液中加入腺苷酸环化酶刺激剂和磷酸二酯酶抑制剂。
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4.发明申请Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light 有权使用核黄素和轻度诱导和维持病原体中的核酸损伤公开(公告)号：US20040081956A1
公开(公告)日：2004-04-29
申请号：US10648536
申请日：2003-08-25
申请人： Gambro, Inc.
IPC分类号： A01N001/02 , A61K038/05 , A61K031/525
CPC分类号： A61L2/084 , A61K41/0019 , A61L2/0011 , A61L2/0082 , A61L2/0088 , A61L2/08 , A61L2/10 , A61L2202/22 , A61M1/0213 , A61M1/3681 , A61M1/3683 , A61M1/3693 , A61M2205/123
摘要： A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.
摘要翻译： 一种损害和维护可能包含在血液或血液成分中的病原体核酸如白细胞，细菌和病毒的损害的过程。 该方法包括向含有病原体的血液或血液成分中加入有效量的核黄素，并将该液体暴露于适当波长的光以损害病原体的核酸，并且基本维持致病性核酸的损伤，以允许 随后输血到接受者。
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