公开(公告)号：US06177795B1

公开(公告)日：2001-01-23

申请号：US09080920

申请日：1998-05-19

申请人： Gang Gary Zhu ,  Jian Huang ,  Hari Hariharan ,  Stephen J. Freeland

发明人： Gang Gary Zhu ,  Jian Huang ,  Hari Hariharan ,  Stephen J. Freeland

IPC分类号： G01V300

CPC分类号： G01R33/4828 ,  G01R33/3415

摘要： A method of using magnetic resonance imaging (MRI) systems for acquiring separate data contributions in images of subjects derived from at least a first and a second spectral components, the method comprising: applying RF pulses; receiving RF signals with a phased array coil arrangement having a plurality of segments; acquiring two initial complex images, the first of the two initial images being a complex image of each of the spectral components in phase; the second of the two initial images being a complex image of each of the spectral components out of phase, the first of said two initial complex images ostensibly being a plus image, and the second of said two complex images ostensibly being a minus image initially; and matching the ostensible plus and minus images so that the first complex images and the second complex images are grouped together for further processing. Preferably, a two-point Dixon method is used to generate the components.

摘要翻译： 一种使用磁共振成像（MRI）系统用于从至少第一和第二光谱分量衍生的对象的图像中获取单独的数据贡献的方法，所述方法包括：应用RF脉冲;接收具有相控阵列线圈装置的RF信号， 多个段;获取两个初始复像，两个初始图像中的第一个是相位中的每个频谱分量的复数图像; 所述两个初始图像中的第二图像是相位不同的每个频谱分量的复数图像，所述两个初始复合图像中的第一个表面上是正图像，并且所述两个复数图像中的第二个初始表示为负图像; 并且匹配表面加和减图像，使得第一复合图像和第二复合图像被分组在一起用于进一步处理。 优选地，使用两点Dixon方法来生成组件。

公开(公告)号：US08686727B2

公开(公告)日：2014-04-01

申请号：US13186981

申请日：2011-07-20

申请人： Ravinder Reddy ,  Hari Hariharan ,  Mohammad Haris ,  Kejia Cai ,  Anup Singh ,  Feliks Kogan

发明人： Ravinder Reddy ,  Hari Hariharan ,  Mohammad Haris ,  Kejia Cai ,  Anup Singh ,  Feliks Kogan

IPC分类号： G01V3/00

CPC分类号： G01R33/5601 ,  G01R33/5605

摘要： The CEST effect for various neurotransmitters and energy metabolites in the brain and muscles and various endogenous metabolites in the liver, brain, and myocardium are imaged using MR imaging to illustrate a unique CEST effect that may be used to monitor the concentration of the metabolite and hence to characterize and monitor various disease states in the body correlated to the concentration of that metabolite. By adjusting the timing, amplitude, and length of the RF pulse as well as other parameters of the CEST pulse sequence to address the unique chemical shifts and exchange rates of the target, new targets with unique characteristics may be acquired using CEST MR imaging.

摘要翻译： 使用MR成像，对脑和肌肉中各种神经递质和能量代谢物以及各种内源性代谢物在肝，脑和心肌中的CEST作用进行成像，以说明独特的CEST效应，可用于监测代谢物的浓度，因此 表征和监测身体与该代谢物浓度相关的各种疾病状态。 通过调整RF脉冲的时间，幅度和长度以及CEST脉冲序列的其他参数来解决目标的独特化学位移和汇率，可以使用CEST MR成像获得具有独特特征的新目标。

公开(公告)号：US20070161890A1

公开(公告)日：2007-07-12

申请号：US11686413

申请日：2007-03-15

申请人： Hari Hariharan ,  Anthony Vu

发明人： Hari Hariharan ,  Anthony Vu

IPC分类号： A61B5/05

CPC分类号： G01R33/5615

摘要： An imaging technique is disclosed to reduce ringing artifacts from amplitude decay in MR multi-echo acquisition. A flip angle train is determined to match scan parameters for an MR scan to acquire MR data from a given tissue. Reducing the effects of amplitude decay in the echo signal reduces ringing artifacts and thereby improves image quality.

摘要翻译： 公开了一种成像技术，以减少MR多回波采集中振幅衰减造成的振铃伪影。 确定一个翻转列车以匹配用于MR扫描的扫描参数以从给定的组织获取MR数据。 降低回波信号中振幅衰减的影响可减少振铃伪影，从而提高图像质量。

公开(公告)号：US07227356B1

公开(公告)日：2007-06-05

申请号：US10711239

申请日：2004-09-03

申请人： Hari Hariharan ,  Anthony Vu

发明人： Hari Hariharan ,  Anthony Vu

IPC分类号： G01V3/00

CPC分类号： G01R33/5615

摘要： An imaging technique is disclosed to reduce ringing artifacts from amplitude decay in MR multi-echo acquisition. A flip angle train is determined to match scan parameters for an MR scan to acquire MR data from a given tissue. Reducing the effects of amplitude decay in the echo signal reduces ringing artifacts and thereby improves image quality.

摘要翻译： 公开了一种成像技术，以减少MR多回波采集中振幅衰减造成的振铃伪影。 确定一个翻转列车以匹配用于MR扫描的扫描参数以从给定的组织获取MR数据。 降低回波信号中振幅衰减的影响可减少振铃伪影，从而提高图像质量。

公开(公告)号：US08115485B1

公开(公告)日：2012-02-14

申请号：US11276714

申请日：2006-03-10

申请人： Joseph K. Maier ,  Hari Hariharan

发明人： Joseph K. Maier ,  Hari Hariharan

IPC分类号： G01V3/00

CPC分类号： G01R33/543 ,  G01R33/4828 ,  G01R33/5613

摘要： A method of calibrating an imaging sequence includes the application of a pre-scan pulse sequence to acquire MR signals from a region-of-interest to be imaged with an imaging pulse sequence. The pre-scan pulse sequence is interrupted to acquire pre-scan data in a low bandwidth acquisition window. A frequency spectrum is generated from the pre-scan data and displayed to interactively allow a user to establish scan parameters for the imaging pulse sequence.

摘要翻译： 校准成像序列的方法包括施加预扫描脉冲序列以从成像脉冲序列成像的感兴趣区域获取MR信号。 预扫描脉冲序列被中断以在低带宽采集窗口中获取预扫描数据。 从预扫描数据产生频谱，并显示为交互地允许用户为成像脉冲序列建立扫描参数。

公开(公告)号：US20120019245A1

公开(公告)日：2012-01-26

申请号：US13186981

申请日：2011-07-20

申请人： Ravinder Reddy ,  Hari Hariharan ,  Mohammad Haris ,  Kejia Cai ,  Anup Singh ,  Feliks Kogan

发明人： Ravinder Reddy ,  Hari Hariharan ,  Mohammad Haris ,  Kejia Cai ,  Anup Singh ,  Feliks Kogan

IPC分类号： G01R33/48

CPC分类号： G01R33/5601 ,  G01R33/5605

摘要： The CEST effect for various neurotransmitters and energy metabolites in the brain and muscles and various endogenous metabolites in the liver, brain, and myocardium are imaged using MR imaging to illustrate a unique CEST effect that may be used to monitor the concentration of the metabolite and hence to characterize and monitor various disease states in the body correlated to the concentration of that metabolite. By adjusting the timing, amplitude, and length of the RF pulse as well as other parameters of the CEST pulse sequence to address the unique chemical shifts and exchange rates of the target, new targets with unique characteristics may be acquired using CEST MR imaging.

摘要翻译： 使用MR成像，对脑和肌肉中各种神经递质和能量代谢物以及各种内源性代谢物在肝，脑和心肌中的CEST作用进行成像，以说明独特的CEST效应，可用于监测代谢物的浓度，因此 表征和监测身体与该代谢物浓度相关的各种疾病状态。 通过调整RF脉冲的时间，幅度和长度以及CEST脉冲序列的其他参数来解决目标的独特化学位移和汇率，可以使用CEST MR成像获得具有独特特征的新目标。

公开(公告)号：US07671590B2

公开(公告)日：2010-03-02

申请号：US11686413

申请日：2007-03-15

申请人： Hari Hariharan ,  Anthony T. Vu

发明人： Hari Hariharan ,  Anthony T. Vu

IPC分类号： G01V3/00

CPC分类号： G01R33/5615

摘要： An imaging technique is disclosed to reduce ringing artifacts from amplitude decay in MR multi-echo acquisition. A flip angle train is determined to match scan parameters for an MR scan to acquire MR data from a given tissue. Reducing the effects of amplitude decay in the echo signal reduces ringing artifacts and thereby improves image quality.

摘要翻译： 公开了一种成像技术，以减少MR多回波采集中振幅衰减造成的振铃伪影。 确定一个翻转列车以匹配用于MR扫描的扫描参数以从给定的组织获取MR数据。 降低回波信号中振幅衰减的影响可减少振铃伪影，从而提高图像质量。

公开(公告)号：US20080146914A1

公开(公告)日：2008-06-19

申请号：US11612727

申请日：2006-12-19

申请人： Jason Andrew Polzin ,  Ralph Eugene Hurd ,  Alexander Ganin ,  Hari Hariharan

发明人： Jason Andrew Polzin ,  Ralph Eugene Hurd ,  Alexander Ganin ,  Hari Hariharan

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B5/0035 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247

摘要： A method for imaging cancer using a combined PET-MRI system takes advantage of the performance characteristics for both PET and MRI in the context of cancer imaging. MRI is used to assess a large area of the body with high sensitivity for cancer and PET is then used in localized areas of concern to provide physiological information. Optionally, MRI may also then be used to re-scan the localized areas of concern with high spatial resolution and additional tissue contrasts to provide anatomical information and soft tissue contrast to supplement the PET information. The use of a combined PET-MRI system ensures that the imaging data from both modalities is accurately referenced to the same locations in the body.

摘要翻译： 使用组合PET-MRI系统对癌症进行成像的方法在癌症成像的背景下利用PET和MRI两者的性能特征。 MRI用于对癌症的高灵敏度的大面积身体进行评估，然后将PET用于关注的局部区域以提供生理信息。 可选地，MRI还可用于重新扫描具有高空间分辨率和附加组织对比度的局部区域，以提供解剖信息和软组织对比度来补充PET信息。 使用组合的PET-MRI系统确保来自两种模式的成像数据准确地参考身体中相同的位置。

公开(公告)号：US07355404B1

公开(公告)日：2008-04-08

申请号：US11275128

申请日：2005-12-13

申请人： Hari Hariharan ,  Joseph D. Schaefer

发明人： Hari Hariharan ,  Joseph D. Schaefer

IPC分类号： G01V3/00

CPC分类号： G01R33/543 ,  G01R33/288

摘要： A method and apparatus for RF deposition prediction model refinement measures an RF parameter during a scan and refines the RF deposition prediction model by a correction factor based on the measured RF parameter.

摘要翻译： 用于RF沉积预测模型细化的方法和装置在扫描期间测量RF参数，并且通过基于所测量的RF参数的校正因子来提炼RF沉积预测模型。