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1.发明授权CEST MRI methods for imaging of metabolites and the use of same as biomarkers 有权CEST用于代谢物成像的MRI方法及其与生物标志物的使用公开(公告)号：US08686727B2
公开(公告)日：2014-04-01
申请号：US13186981
申请日：2011-07-20
申请人： Ravinder Reddy , Hari Hariharan , Mohammad Haris , Kejia Cai , Anup Singh , Feliks Kogan
发明人： Ravinder Reddy , Hari Hariharan , Mohammad Haris , Kejia Cai , Anup Singh , Feliks Kogan
IPC分类号： G01V3/00
CPC分类号： G01R33/5601 , G01R33/5605
摘要： The CEST effect for various neurotransmitters and energy metabolites in the brain and muscles and various endogenous metabolites in the liver, brain, and myocardium are imaged using MR imaging to illustrate a unique CEST effect that may be used to monitor the concentration of the metabolite and hence to characterize and monitor various disease states in the body correlated to the concentration of that metabolite. By adjusting the timing, amplitude, and length of the RF pulse as well as other parameters of the CEST pulse sequence to address the unique chemical shifts and exchange rates of the target, new targets with unique characteristics may be acquired using CEST MR imaging.
摘要翻译： 使用MR成像，对脑和肌肉中各种神经递质和能量代谢物以及各种内源性代谢物在肝，脑和心肌中的CEST作用进行成像，以说明独特的CEST效应，可用于监测代谢物的浓度，因此 表征和监测身体与该代谢物浓度相关的各种疾病状态。 通过调整RF脉冲的时间，幅度和长度以及CEST脉冲序列的其他参数来解决目标的独特化学位移和汇率，可以使用CEST MR成像获得具有独特特征的新目标。
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2.发明申请CEST MRI METHODS FOR IMAGING OF METABOLITES AND THE USE OF SAME AS BIOMARKERS 有权用于成像代谢物的CEST MRI方法及其作为生物标志物的用途公开(公告)号：US20120019245A1
公开(公告)日：2012-01-26
申请号：US13186981
申请日：2011-07-20
申请人： Ravinder Reddy , Hari Hariharan , Mohammad Haris , Kejia Cai , Anup Singh , Feliks Kogan
发明人： Ravinder Reddy , Hari Hariharan , Mohammad Haris , Kejia Cai , Anup Singh , Feliks Kogan
IPC分类号： G01R33/48
CPC分类号： G01R33/5601 , G01R33/5605
摘要： The CEST effect for various neurotransmitters and energy metabolites in the brain and muscles and various endogenous metabolites in the liver, brain, and myocardium are imaged using MR imaging to illustrate a unique CEST effect that may be used to monitor the concentration of the metabolite and hence to characterize and monitor various disease states in the body correlated to the concentration of that metabolite. By adjusting the timing, amplitude, and length of the RF pulse as well as other parameters of the CEST pulse sequence to address the unique chemical shifts and exchange rates of the target, new targets with unique characteristics may be acquired using CEST MR imaging.
摘要翻译： 使用MR成像，对脑和肌肉中各种神经递质和能量代谢物以及各种内源性代谢物在肝，脑和心肌中的CEST作用进行成像，以说明独特的CEST效应，可用于监测代谢物的浓度，因此 表征和监测身体与该代谢物浓度相关的各种疾病状态。 通过调整RF脉冲的时间，幅度和长度以及CEST脉冲序列的其他参数来解决目标的独特化学位移和汇率，可以使用CEST MR成像获得具有独特特征的新目标。
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公开(公告)号：US20050151537A1
公开(公告)日：2005-07-14
申请号：US10991888
申请日：2004-11-18
CPC分类号： G01R33/482
摘要： Provided is a T1ρ-weighted pulse sequence with reduced specific absorption rate for magnetic resonance imaging (MRI). Also provided is a method of reducing the specific absorption rate in T1ρ-weighted MRI.
摘要翻译： 提供了一种具有降低的磁共振成像（MRI）的比吸收率的T 1/2 +加权脉冲序列。 还提供了降低T 1加权MRI中的比吸收率的方法。
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公开(公告)号：US08526695B2
公开(公告)日：2013-09-03
申请号：US12595462
申请日：2009-10-09
CPC分类号： A61B5/055 , A61B5/4514 , G01R33/56 , G01R33/5608
摘要： Methods of, and systems for, magnetic resonance imaging of diagnostic mapping of tissues, where sodium mapping is performed individually, as well as in combination with other images of tissue, such as T1ρ, T2, and/or T1-weighted images. In one method embodiment, a sodium image of the tissue is acquired during the same scanning session. Maps are constructed of each of the first and sodium images individually, and in combination, and further facilitate viewing in combination with each other as a single, blended image of the tissue. Maps of the images may be displayed individually or in combination with each other.
摘要翻译： 用于组织诊断图的磁共振成像的方法和系统，其中单独进行钠映射，以及与组织的其他图像（例如T1rho，T2和/或T1加权图像）组合。 在一个方法实施例中，在相同的扫描会话期间获取组织的钠图像。 地图由第一和钠图像中的每一个单独构成，并且组合，并且进一步便于彼此组合的观看，作为组织的单个混合图像。 图像的地图可以单独显示或彼此组合显示。
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5.发明授权Spin locked balanced steady-state free precession (slSSFP) with off-resonance spin locked pulses interleaved with imaging gradients 有权旋转锁定平衡稳态自由进动（slSSFP），具有与成像梯度交错的非共振自旋锁定脉冲公开(公告)号：US08148982B2
公开(公告)日：2012-04-03
申请号：US12426703
申请日：2009-04-20
IPC分类号： G01V3/00
CPC分类号： G01R33/5605 , G01R33/5614
摘要： A spin locked balanced steady-state free precession (slSSFP) pulse sequence combines a balanced gradient echo acquisition with an off-resonance spin lock pulse for fast MRI. The transient and steady-state magnetization trajectory is solved numerically using the Bloch equations and is shown to be similar to balanced steady-state free precession (bSSFP) for a range of T2/T1 and flip angles, although the slSSFP steady-state could be maintained with considerably lower RF power. In both simulations and brain scans performed at 7T, slSSFP is shown to exhibit similar contrast and SNR efficiency to bSSFP, but with significantly lower power.
摘要翻译： 自旋锁定平衡稳态自由进动（slSSFP）脉冲序列将平衡梯度回波采集与偏共振自旋锁定脉冲相结合，用于快速MRI。 瞬态和稳态磁化轨迹使用Bloch方程数值求解，并且显示为类似于T2 / T1和翻转角范围内的平衡稳态自由进动（bSSFP），尽管slSSFP稳态可以 维持相当低的射频功率。 在7T进行的两次模拟和脑扫描中，slSSFP显示出与bSSFP相似的对比度和SNR效率，但功率显着降低。
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公开(公告)号：US07116104B2
公开(公告)日：2006-10-03
申请号：US10991888
申请日：2004-11-18
IPC分类号： G01V3/00
CPC分类号： G01R33/482
摘要： Provided is a T1ρ-weighted pulse sequence with reduced specific absorption rate for magnetic resonance imaging (MRI). Also provided is a method of reducing the specific absorption rate in T1ρ-weighted MRI.
摘要翻译： 提供了一种具有降低的磁共振成像（MRI）的比吸收率的T 1/2 +加权脉冲序列。 还提供了降低T 1加权MRI中的比吸收率的方法。
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7.发明授权Method and apparatus for providing pulses inhalation of 17O2 for magnetic resonance imaging of cerebral metabolism 有权提供脉冲吸入17O2用于脑代谢的磁共振成像的方法和装置公开(公告)号：US08554305B2
公开(公告)日：2013-10-08
申请号：US12669854
申请日：2008-07-18
CPC分类号： A61B5/055 , A61B5/0033 , A61B5/0833 , A61B5/0836 , A61B5/7207 , G01R33/5601 , G01R33/56366
摘要： Prior approaches have delivered 17O2 to a subject by inhalation, but the relationship between local signal changes and metabolism has been complicated by H217O created in non-cerebral tissues. During a brief pulse of 17O2 inhalation, this arterial input function for H217O is negligible due to convective transport delays. Additional delays in the arterial input function due to restricted diffusion of water makes pulsed inhalation of 17O2 even more effective. Accordingly, ventilator system are provided to deliver 17O2 as a brief pulse to a subject. Subsequent MR imaging demonstrates delayed appearance of H217O in the cerebral ventricles, suggesting that the arterial input function of H217O is delayed by restricted water diffusion in addition to convective transit delays. Delivery as a brief pulse therefore offers significant advantages in relating MR signal changes directly to metabolism.
摘要翻译： 以前的方法已经通过吸入将17O2提供给受试者，但是在非脑组织中产生的H217O，局部信号变化和代谢之间的关系已经复杂化。 在17O2吸入的短暂脉冲期间，H217O的这种动脉输入功能由于对流运输延迟而可忽略不计。 由于水分扩散引起的动脉输入功能的额外延迟使17O2的脉冲吸入更有效。 因此，提供呼吸机系统以将作为短暂脉冲的17O2输送到受试者。 随后的MR成像显示H217O在脑室中的延迟出现，表明H217O的动脉输入功能除了对流转运延迟之外，受到限制性水扩散的延迟。 因此，作为短暂脉冲的交付提供了将MR信号变化直接与新陈代谢相关联的显着优点。
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公开(公告)号：US20090273343A1
公开(公告)日：2009-11-05
申请号：US12425130
申请日：2009-04-16
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , G01R33/50 , G01R33/5602 , G01R33/5613 , G01R33/5614 , G01R33/5617
摘要： Provided are methods and systems for rapid MRI imaging-scanning that provides 2D or 3D coverage, high precision, and high-temporal efficiency, without exceeding SAR limits. In one embodiment, a pulse sequence process is performed that includes a T1ρ preparation period, followed by a very rapid image acquisition process, which acquires multiple lines of k-space data. The combination of T1ρ preparation and acquisition of multiple lines of k-space, allows scan times to be shortened by as much as 3- or 4-fold or more, over conventional MRI scanning methods.
摘要翻译： 提供了用于快速MRI成像扫描的方法和系统，其提供2D或3D覆盖，高精度和高时间效率，而不超过SAR限制。 在一个实施例中，执行脉冲序列处理，其包括T1rho准备周期，随后是非常快速的图像获取过程，其获取多行k空间数据。 与常规MRI扫描方法相比，T1rho准备和多行k空间采集的组合使扫描时间缩短了3至4倍或更多。
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公开(公告)号：US08076936B2
公开(公告)日：2011-12-13
申请号：US12425130
申请日：2009-04-16
申请人： Ari Borthakur , Ravinder Reddy , Sridhar Charagundla , Jyothsna Charagundla, legal representative
IPC分类号： G01V3/00
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , G01R33/50 , G01R33/5602 , G01R33/5613 , G01R33/5614 , G01R33/5617
摘要： Provided are methods and systems for rapid MRI imaging-scanning that provides 2D or 3D coverage, high precision, and high-temporal efficiency, without exceeding SAR limits. In one embodiment, a pulse sequence process is performed that includes a T1ρ preparation period, followed by a very rapid image acquisition process, which acquires multiple lines of k-space data. The combination of T1ρ preparation and acquisition of multiple lines of k-space, allows scan times to be shortened by as much as 3- or 4-fold or more, over conventional MRI scanning methods.
摘要翻译： 提供了用于快速MRI成像扫描的方法和系统，其提供2D或3D覆盖，高精度和高时间效率，而不超过SAR限制。 在一个实施例中，执行脉冲序列处理，其包括T1＆rgr; 准备期间，其次是非常快速的图像采集过程，其获取多行k空间数据。 T1＆rgr的组合 准备和获取多行k空间，允许扫描时间比常规MRI扫描方法缩短多至3或4倍或更多。
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10.发明申请公开(公告)号：US20100282258A1
公开(公告)日：2010-11-11
申请号：US12669854
申请日：2008-07-18
IPC分类号： A61M16/00
CPC分类号： A61B5/055 , A61B5/0033 , A61B5/0833 , A61B5/0836 , A61B5/7207 , G01R33/5601 , G01R33/56366
摘要： Prior approaches have delivered O2 to a subject by inhalation, but the relationship between local signal changes and metabolism has been complicated by H217O created in non-cerebral tissues. During a brief pulse of 17O2 inhalation, this arterial input function for H217O is negligible due to convective transport delays. Additional delays in the arterial input function due to restricted diffusion of water makes pulsed inhalation of 17O2 even more effective. Accordingly, ventilator system are provided to deliver 17O2 as a brief pulse to a subject. Subsequent MR imaging demonstrates delayed appearance of H217O in the cerebral ventricles, suggesting that the arterial input function of H217O is delayed by restricted water diffusion in addition to convective transit delays. Delivery as a brief pulse therefore offers significant advantages in relating MR signal changes directly to metabolism.
摘要翻译： 以前的方法通过吸入将O2传递给受试者，但是在非脑组织中产生的H217O，局部信号变化和代谢之间的关系已经复杂化。 在17O2吸入的短暂脉冲期间，H217O的这种动脉输入功能由于对流运输延迟而可忽略不计。 由于水分扩散引起的动脉输入功能的额外延迟使得17O2的脉冲吸入更有效。 因此，提供呼吸机系统以将作为短暂脉冲的17O2输送到受试者。 随后的MR成像显示H217O在脑室中的延迟出现，表明H217O的动脉输入功能除了对流转运延迟之外，受到限制性水扩散的延迟。 因此，作为短暂脉冲的交付提供了将MR信号变化直接与新陈代谢相关联的显着优点。
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