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    Hydroxybenzoate salts of metanicotine compounds
    1.
    发明申请
    Hydroxybenzoate salts of metanicotine compounds 审中-公开

    公开(公告)号：US20060122238A1

    公开(公告)日：2006-06-08

    申请号：US11270753

    申请日：2005-11-09

    申请人： Gary Dull ,  Julio Munoz ,  John Genus ,  James Moore

    发明人： Gary Dull ,  Julio Munoz ,  John Genus ,  James Moore

    IPC分类号： A61K31/44 ,  C07D213/26

    CPC分类号： C07D213/38 ,  C07D213/65 ,  C07D213/73 ,  C07D213/75 ,  C07D401/12

    摘要： Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, as the hydroxybenzoate salts tend to crystallize out, leaving impurities such as Z-metanicotine compounds, and compounds where the double bond has migrated, in solution. If desired, the hydroxybenzoate salts can be converted to either the free base (the E-metanicotine) or to another pharmaceutically acceptable salt form.

    Hydroxybenzoate Salts Of Metanicotine Compounds
    3.
    发明申请
    Hydroxybenzoate Salts Of Metanicotine Compounds 有权
    间苯二酚化合物的羟基苯甲酸盐

    公开(公告)号：US20090062321A1

    公开(公告)日：2009-03-05

    申请号：US12264288

    申请日：2008-11-04

    申请人： Julio A. Munoz ,  John Genus ,  James R. Moore

    发明人： Julio A. Munoz ,  John Genus ,  James R. Moore

    IPC分类号： A61K31/44 ,  A61P25/00 ,  C07D213/36

    CPC分类号： A61K31/4406 ,  A61K31/192 ,  A61K31/44 ,  A61K31/4412 ,  C07D213/38 ,  C07D213/65 ,  C07D213/73 ,  C07D213/75 ,  C07D401/12

    摘要： Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, as the hydroxybenzoate salts tend to crystallize out, leaving impurities such as Z-metanicotine compounds, and compounds where the double bond has migrated, in solution. If desired, the hydroxybenzoate salts can be converted to either the free base (the E-metanicotine) or to another pharmaceutically acceptable salt form.

    摘要翻译： 通过向有需要的患者施用作为E-间断脒类化合物的羟基苯甲酸盐的组合物来治疗易患或患有病症和障碍的患者，例如中枢神经系统疾病。 E-间烟碱化合物的羟基苯甲酸盐的形成也可用于纯化E-间烟碱化合物，因为羟基苯甲酸盐倾向于结晶出来，留下杂质如Z-间苯ic啶化合物和双键已经迁移的化合物 解。 如果需要，羟基苯甲酸盐可以转化为游离碱（E-间烟碱）或另一种药学上可接受的盐形式。

    Hydroxybenzoate salts of metanicotine compounds
    5.
    发明授权
    Hydroxybenzoate salts of metanicotine compounds 失效
    间苯ine啶化合物的羟基苯甲酸盐

    公开(公告)号：US08580826B2

    公开(公告)日：2013-11-12

    申请号：US13281716

    申请日：2011-10-26

    申请人： Julio A. Munoz ,  John Genus ,  James R. Moore

    发明人： Julio A. Munoz ,  John Genus ,  James R. Moore

    IPC分类号： A61K31/44 ,  A61P25/28 ,  A61P25/00 ,  C07D213/65 ,  C07D213/36

    CPC分类号： A61K31/4406 ,  A61K31/192 ,  A61K31/44 ,  A61K31/4412 ,  C07D213/38 ,  C07D213/65 ,  C07D213/73 ,  C07D213/75 ,  C07D401/12

    摘要： Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, as the hydroxybenzoate salts tend to crystallize out, leaving impurities such as Z-metanicotine compounds, and compounds where the double bond has migrated, in solution. If desired, the hydroxybenzoate salts can be converted to either the free base (the E-metanicotine) or to another pharmaceutically acceptable salt form.

    摘要翻译： 通过向有需要的患者施用作为E-间断脒类化合物的羟基苯甲酸盐的组合物来治疗易患或患有病症和障碍的患者，例如中枢神经系统疾病。 E-间烟碱化合物的羟基苯甲酸盐的形成也可用于纯化E-间烟碱化合物，因为羟基苯甲酸盐倾向于结晶出来，留下杂质如Z-间苯ic啶化合物和双键已经迁移的化合物 解。 如果需要，羟基苯甲酸盐可以转化为游离碱（E-间烟碱）或另一种药学上可接受的盐形式。

    HYDROXYBENZOATE SALTS OF METANICOTINE COMPOUNDS
    8.
    发明申请
    HYDROXYBENZOATE SALTS OF METANICOTINE COMPOUNDS 失效
    金属化合物的羟基苯甲酸盐

    公开(公告)号：US20120041033A1

    公开(公告)日：2012-02-16

    申请号：US13281716

    申请日：2011-10-26

    申请人： Julio A. Munoz ,  John Genus ,  James R. Moore

    发明人： Julio A. Munoz ,  John Genus ,  James R. Moore

    IPC分类号： A61K31/44 ,  A61P25/28 ,  A61P25/00 ,  C07D213/65 ,  C07D213/36

    CPC分类号： A61K31/4406 ,  A61K31/192 ,  A61K31/44 ,  A61K31/4412 ,  C07D213/38 ,  C07D213/65 ,  C07D213/73 ,  C07D213/75 ,  C07D401/12

    摘要： Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, as the hydroxybenzoate salts tend to crystallize out, leaving impurities such as Z-metanicotine compounds, and compounds where the double bond has migrated, in solution. If desired, the hydroxybenzoate salts can be converted to either the free base (the E-metanicotine) or to another pharmaceutically acceptable salt form.

    摘要翻译： 通过向有需要的患者施用作为E-间断脒类化合物的羟基苯甲酸盐的组合物来治疗易患或患有病症和障碍的患者，例如中枢神经系统疾病。 E-间烟碱化合物的羟基苯甲酸盐的形成也可用于纯化E-间烟碱化合物，因为羟基苯甲酸盐倾向于结晶出来，留下杂质如Z-间苯ic啶化合物和双键已经迁移的化合物 解。 如果需要，羟基苯甲酸盐可以转化为游离碱（E-间烟碱）或另一种药学上可接受的盐形式。

    HYDROXYBENZOATE SALTS OF METANICOTINE COMPOUNDS
    9.
    发明申请
    HYDROXYBENZOATE SALTS OF METANICOTINE COMPOUNDS 审中-公开
    金属化合物的羟基苯甲酸盐

    公开(公告)号：US20080249142A1

    公开(公告)日：2008-10-09

    申请号：US12142471

    申请日：2008-06-19

    申请人： Gary Maurice Dull ,  Julio A. Munoz ,  John Genus ,  James R. Moore

    发明人： Gary Maurice Dull ,  Julio A. Munoz ,  John Genus ,  James R. Moore

    IPC分类号： A61K31/44 ,  A61P25/00 ,  A61P25/28 ,  A61P25/16

    CPC分类号： C07D213/38 ,  C07D213/65 ,  C07D213/73 ,  C07D213/75 ,  C07D401/12

    摘要： Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, as the hydroxybenzoate salts tend to crystallize out, leaving impurities such as Z-metanicotine compounds, and compounds where the double bond has migrated, in solution. If desired, the hydroxybenzoate salts can be converted to either the free base (the E-metanicotine compound) or to another pharmaceutically acceptable salt form.

    摘要翻译： 通过向有需要的患者施用作为E-间断脒类化合物的羟基苯甲酸盐的组合物来治疗易患或患有病症和障碍的患者，例如中枢神经系统疾病。 E-间烟碱化合物的羟基苯甲酸盐的形成也可用于纯化E-间烟碱化合物，因为羟基苯甲酸盐倾向于结晶出来，留下杂质如Z-间苯ic啶化合物和双键已经迁移的化合物 解。 如果需要，羟基苯甲酸盐可以转化为游离碱（E-间烟碱化合物）或另一种药学上可接受的盐形式。