公开(公告)号：US20060217551A1

公开(公告)日：2006-09-28

申请号：US10543380

申请日：2004-01-30

申请人： Gary Evans ,  Peter Tyler

发明人： Gary Evans ,  Peter Tyler

IPC分类号： C07D487/02

CPC分类号： C07H19/23

摘要： The present invention relates to a new process for the preparation of compounds of general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine nucleosidases (MTAN) and/or nucleoside hydrolases (NH).The present invention relates to a new process for the preparation of compounds of general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine nucleosidases (MTAN) and/or nucleoside hydrolases (NH).

摘要翻译： 本发明涉及制备嘌呤核苷磷酸化酶（PNP），嘌呤磷酸核糖转移酶（PPRT），5'-甲硫基腺苷磷酸化酶（MTAP），5'-甲硫基腺苷核苷酸酶抑制剂的通式（I）化合物的新方法 （MTAN）和/或核苷水解酶（NH）。本发明涉及制备通式（I）化合物的新方法，其为嘌呤核苷磷酸化酶（PNP），嘌呤磷酸核糖基转移酶（PPRT），5' 甲基硫代腺苷磷酸酶（MTAP），5'-甲硫基腺苷核苷酸（MTAN）和/或核苷水解酶（NH）。

公开(公告)号：US20060160765A1

公开(公告)日：2006-07-20

申请号：US10524995

申请日：2003-08-21

申请人： Gary Evans ,  Richard Hubert ,  Dirk Lenz ,  Vern Schramm ,  Peter Tyler ,  Olga Zubkova

发明人： Gary Evans ,  Richard Hubert ,  Dirk Lenz ,  Vern Schramm ,  Peter Tyler ,  Olga Zubkova

IPC分类号： A61K31/7076 ,  A61K31/519 ,  C07H19/16 ,  A61K31/655 ,  C07D487/02

CPC分类号： C07D473/30 ,  C07D473/34 ,  C07H19/23

摘要： The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

摘要翻译： 本发明涉及作为嘌呤粘蛋白磷酸化酶（PNP），嘌呤磷酸核糖基转移酶（PPRT），5'-甲硫基腺苷磷酸化酶（MTAP），5'-甲硫基腺苷粘蛋白酶（MTAN）和/或 核苷水解酶（NH）。 本发明还涉及这些化合物在治疗包括癌症，细菌感染，原生动物感染和T细胞介导的疾病的疾病和感染中的用途以及含有该化合物的药物组合物。

公开(公告)号：US20070269448A1

公开(公告)日：2007-11-22

申请号：US10570673

申请日：2004-09-09

申请人： Vern Schramm ,  Richard Furneaux ,  Peter Tyler ,  Gary Evans

发明人： Vern Schramm ,  Richard Furneaux ,  Peter Tyler ,  Gary Evans

IPC分类号： A61K39/395 ,  A61K31/7076 ,  A61P35/00 ,  C07H19/16

CPC分类号： C12N15/11 ,  C12N2310/13 ,  C12N2310/323 ,  C12N2310/333 ,  C12N2310/53

摘要： Improved transition state analog inhibitors of ricin toxin-A are provided. Methods of using those inhibitors to inhibit ricin toxin-A and to prevent the toxic effects of rich toxin-A in a mammal are also provided.

摘要翻译： 提供了改进的蓖麻毒素-A的过渡态类似物抑制剂。 还提供了使用这些抑制剂来抑制蓖麻毒素-A并且防止浓毒素-A在哺乳动物中的毒性作用的方法。

公开(公告)号：US20110286302A1

公开(公告)日：2011-11-24

申请号：US13117984

申请日：2011-05-27

申请人： Ken WELKER ,  Peter Tyler

发明人： Ken WELKER ,  Peter Tyler

IPC分类号： G01V1/38

CPC分类号： G01V1/3826

摘要： An inventive method provides for control of a seismic survey spread while conducting a seismic survey, the spread having a vessel, a plurality of spread control elements, a plurality of navigation nodes, and a plurality of sources and receivers. The method includes the step of collecting input data, including navigation data for the navigation nodes, operating states from sensors associated with the spread control elements, environmental data for the survey, and survey design data. The positions of the sources and receivers are estimated using the navigation data, the operating states, and the environmental data. Optimum tracks for the sources and receivers are determined using the position estimates and a portion of the input data that includes at least the survey design data. Drive commands are calculated for at least two of the spread control elements using the determined optimum tracks. The inventive method is complemented by an inventive system.

摘要翻译： 本发明的方法提供了在进行地震测量时对地震勘测扩展的控制，扩展具有容器，多个扩展控制元件，多个导航节点以及多个源和接收器。 该方法包括收集输入数据的步骤，包括导航节点的导航数据，与扩展控制元件相关联的传感器的操作状态，用于测量的环境数据和勘测设计数据。 使用导航数据，操作状态和环境数据来估计源和接收器的位置。 使用位置估计和至少包括勘测设计数据的输入数据的一部分来确定源和接收器的最佳轨迹。 使用所确定的最佳轨迹，针对至少两个扩展控制元件计算驱动命令。 本发明的方法由本发明的系统补充。

公开(公告)号：US20080172272A1

公开(公告)日：2008-07-17

申请号：US12015496

申请日：2008-01-16

申请人： Michael Back ,  Daniel Fichter ,  Doug MacDonald ,  Peter Tyler ,  Roger Gallant ,  Dave Mason

发明人： Michael Back ,  Daniel Fichter ,  Doug MacDonald ,  Peter Tyler ,  Roger Gallant ,  Dave Mason

IPC分类号： G06F17/00

CPC分类号： G06Q10/06 ,  G06Q10/0637 ,  G06Q10/06375 ,  G06Q30/0202

摘要： A method of performing oilfield operations for an oilfield having a subterranean formation with a reservoir therein is provided. The method involves generating a business analysis of the oilfield based on business inputs, generating an operational analysis of the oilfield based on operational inputs, and selectively integrating the business analysis with the operational analysis by using the operational outputs as at least a portion of the business inputs and by using the business outputs as at least a portion of the operational inputs to form an integrated oilfield analysis. The business analysis includes business outputs for characterizing the business impact of projects performed on the oilfield. The operational analysis includes operational outputs for characterizing the operational impact of projects performed on the oilfield. The integrated oilfield analysis includes integrated oilfield outputs for characterizing the business and operational impact of projects performed on the oilfield. The method may also involve developing an oilfield plan based on the integrated oilfield analysis and implementing the oilfield plan.

摘要翻译： 提供了一种对具有储存器的地层的油田进行油田作业的方法。 该方法包括根据业务投入产生对油田的业务分析，根据运营投入产生对油田的运营分析，并将业务分析与运营分析结合使用作为至少部分业务的运营成果进行选择性整合 输入和使用业务输出作为至少一部分操作输入，以形成综合油田分析。 业务分析包括用于表征在油田上进行的项目的业务影响的业务输出。 操作分析包括用于描述在油田进行的项目的运行影响的运行输出。 综合油田分析包括综合油田产量，用于描述在油田进行的项目的业务和运营影响。 该方法还可能涉及基于综合油田分析和实施油田计划开发油田计划。

公开(公告)号：US20070197561A1

公开(公告)日：2007-08-23

申请号：US11728730

申请日：2007-03-26

申请人： Richard Furneaux ,  Peter Tyler ,  Vern Schramm

发明人： Richard Furneaux ,  Peter Tyler ,  Vern Schramm

IPC分类号： A61K31/519 ,  C07D487/02

CPC分类号： C07D487/04 ,  C07H19/04

摘要： The present invention provides compounds having the formula: wherein A is CH or N; B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H, halogen or SCH3; R is an optionally substituted alkyl, aralkyl or aryl group; and X and Y are independently selected from H, OH or halogen except that when one of X and Y is hydroxy or halogen, the other is hydrogen; and Z is OH or, when X is hydroxy, Z is selected from hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof; and compounds having the formula: wherein A, X, Y, Z and R are defined for compounds of formula (I) where first shown above; E is chosen from CO2H or a corresponding salt form, CO2R, CN, CONH2, CONHR or CONR2; and G is chosen from NH2, NHCOR, NHCONHR or NHCSNHR; or a tautomer thereof, or a pharmaceutically acceptable salt thereof, or an ester thereof, or a prodrug thereof. The present invention also provides the use of the above compounds as pharmaceuticals, pharmaceutical compositions containing the compounds and processes for preparing the compounds.

摘要翻译： 本发明提供具有下式的化合物：其中A是CH或N; B选自OH，NH 2，NHR，H或卤素; D选自OH，NH 2，NHR，H，卤素或SCH 3; R是任选取代的烷基，芳烷基或芳基; X和Y独立地选自H，OH或卤素，除了当X和Y中的一个是羟基或卤素时，另一个是氢; Z为OH或当X为羟基时，Z选自氢，卤素，羟基，SQ或OQ，Q为任选取代的烷基，芳烷基或芳基; 或其互变异构体; 或其药学上可接受的盐; 或其酯; 或其前药; 和具有下式的化合物：其中A，X，Y，Z和R定义为其中首先显示的式（I）化合物; E选自CO 2 H或相应的盐形式，CO 2 R，CN，CONH 2，CONHR或CONR 2 并且G选自NH 2，NHCOR，NHCONHR或NHCSNHR; 或其互变异构体，或其药学上可接受的盐或其酯，或其前药。 本发明还提供了上述化合物作为药物，含有该化合物的药物组合物和制备该化合物的方法的用途。

公开(公告)号：US20110149682A1

公开(公告)日：2011-06-23

申请号：US10530695

申请日：2003-10-13

申请人： James Edward Martin ,  Svein Arne Frivik ,  Peter Tyler ,  Kyrre Tjoem

发明人： James Edward Martin ,  Svein Arne Frivik ,  Peter Tyler ,  Kyrre Tjoem

IPC分类号： G01V1/38

CPC分类号： G01V1/3835

摘要： The present invention provides a method and apparatus for determining the position of a seismic cable being used to perform a marine seismic survey. The apparatus includes at least one seismic sensor and a plurality of sources deployed in a manner that is structurally independent of the seismic sensors and adapted to provide a positioning signal distinguishable from a seismic survey signal to the seismic sensors.

摘要翻译： 本发明提供一种用于确定用于执行海洋地震勘测的地震索的位置的方法和装置。 该装置包括至少一个地震传感器和多个源，其结构上独立于地震传感器并且适于向地震传感器提供与地震勘测信号区分开的定位信号。

公开(公告)号：US20070015772A1

公开(公告)日：2007-01-18

申请号：US11486954

申请日：2006-07-13

申请人： Richard Furneaux ,  Peter Tyler ,  Vern Schramm

发明人： Richard Furneaux ,  Peter Tyler ,  Vern Schramm

IPC分类号： C07D487/02 ,  A61K31/519

CPC分类号： C07H19/14

摘要： The present invention provides a compound of formula (I), wherein: A is selected from N, CH and CR, where R is selected from halogen, optionally substituted alkyl, aralkyl and aryl, OH, NH2, NHR1, NR1R2 and SR3, where R1, R2 and R3 are each optionally substituted alkyl, aralkyl or aryl groups; B is selected from OH, NH2, NHR4, H and halogen, where R4 is an optionally substituted alkyl, aralkyl or aryl group; D is selected from OH, NH2, NHR5, H, halogen and SCH3, where R5 is an optionally substituted alkyl, aralkyl or aryl group; X and Y are independently selected from H, OH and halogen, with the proviso that when one of X and Y is hydroxy or halogen, the other is hydrogen; Z is OH, or, when X is hydroxy, Z is selected from hydrogen, halogen, hydroxy, SQ and OQ, where Q is an optionally substituted alkyl, aralkyl or aryl group; and W is OH or H, with the proviso that when W is OH, then A is CR where R is as defined above; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof. The invention also provides a pharmaceutical composition comprising a compound of formula (I), as well as methods of treatment using a compound of formula (I). The invention further provides methods of preparing compounds of formula (I).

摘要翻译： 本发明提供式（I）化合物，其中：A选自N，CH和CR，其中R选自卤素，任选取代的烷基，芳烷基和芳基，OH，NH 2， ，NHR 1，NR 1，R 2和SR 3，其中R 1， R 2和R 3各自为任选取代的烷基，芳烷基或芳基; B选自OH，NH 2，NHR 4，H和卤素，其中R 4是任选取代的烷基，芳烷基或芳基 ; D选自OH，NH 2，NHR 5，H，卤素和SCH 3，其中R 5， 是任选取代的烷基，芳烷基或芳基; X和Y独立地选自H，OH和卤素，条件是当X和Y中的一个是羟基或卤素时，另一个是氢; Z是OH，或当X是羟基时，Z选自氢，卤素，羟基，SQ和OQ，其中Q是任选取代的烷基，芳烷基或芳基; 并且W是OH或H，条件是当W是OH时，则A是CR，其中R如上定义; 或其互变异构体; 或其药学上可接受的盐; 或其酯; 或其前药。 本发明还提供了包含式（I）化合物的药物组合物，以及使用式（I）化合物的治疗方法。 本发明还提供制备式（I）化合物的方法。

公开(公告)号：US20050026936A1

公开(公告)日：2005-02-03

申请号：US10932841

申请日：2004-09-02

申请人： Richard Furneaux ,  Peter Tyler ,  Vern Schramm

发明人： Richard Furneaux ,  Peter Tyler ,  Vern Schramm

IPC分类号： C07D487/04 ,  A01N43/04 ,  A01N61/00 ,  A61K31/519 ,  A61P33/06 ,  A61P37/06 ,  A61P43/00 ,  C07D207/34 ,  C07D403/04 ,  C07D487/02 ,  C07H19/00 ,  C07H19/04 ,  C07H21/00

CPC分类号： C07D487/04 ,  C07H19/04

摘要： The present invention provides compounds having the formula: wherein A is CH or N; B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H, halogen or SCH3; R is an optionally substituted alkyl, aralkyl or aryl group; and X and Y are independently selected from H, OH or halogen except that when one of X and Y is hydroxy or halogen, the other is hydrogen; and Z is OH or, when X is hydroxy, Z is selected from hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof; and compounds having the formula: wherein A, X, Y, Z and R are defined for compounds of formula (I) where first shown above; E is chosen from CO2H or a corresponding salt form, CO2R, CN, CONH2, CONHR or CONR2; and G is chosen from NH2, NHCOR, NHCONHR or NHCSNHR; or a tautomer thereof, or a pharmaceutically acceptable salt thereof, or an ester thereof, or a prodrug thereof. The present invention also provides the use of the above compounds as pharmaceuticals, pharmaceutical compositions containing the compounds and processes for preparing the compounds.

摘要翻译： 本发明提供具有下式的化合物：其中A是CH或N; B选自OH，NH2，NHR，H或卤素; D选自OH，NH 2，NHR，H，卤素或SCH 3; R是任选取代的烷基，芳烷基或芳基; X和Y独立地选自H，OH或卤素，除了当X和Y中的一个是羟基或卤素时，另一个是氢; Z为OH或当X为羟基时，Z选自氢，卤素，羟基，SQ或OQ，Q为任选取代的烷基，芳烷基或芳基; 或其互变异构体; 或其药学上可接受的盐; 或其酯; 或其前药; 和具有下式的化合物：其中A，X，Y，Z和R定义为其中首先显示的式（I）化合物; E选自CO 2 H或相应的盐形式，CO 2 R，CN，CONH 2，CONHR或CONR 2; G选自NH2，NHCOR，NHCONHR或NHCSNHR; 或其互变异构体，或其药学上可接受的盐或其酯，或其前药。 本发明还提供了上述化合物作为药物，含有该化合物的药物组合物和制备该化合物的方法的用途。

公开(公告)号：US08190458B2

公开(公告)日：2012-05-29

申请号：US12015496

申请日：2008-01-16

申请人： Michael Back ,  Daniel Fichter ,  Doug MacDonald ,  Peter Tyler ,  Roger Gallant ,  Dave Mason

发明人： Michael Back ,  Daniel Fichter ,  Doug MacDonald ,  Peter Tyler ,  Roger Gallant ,  Dave Mason

IPC分类号： G06Q10/00

CPC分类号： G06Q10/06 ,  G06Q10/0637 ,  G06Q10/06375 ,  G06Q30/0202

摘要： A method of performing oilfield operations for an oilfield having a subterranean formation with a reservoir therein is provided. The method involves generating a business analysis of the oilfield based on business inputs, generating an operational analysis of the oilfield based on operational inputs, and selectively integrating the business analysis with the operational analysis by using the operational outputs as at least a portion of the business inputs and by using the business outputs as at least a portion of the operational inputs to form an integrated oilfield analysis. The business analysis includes business outputs for characterizing the business impact of projects performed on the oilfield. The operational analysis includes operational outputs for characterizing the operational impact of projects performed on the oilfield. The integrated oilfield analysis includes integrated oilfield outputs for characterizing the business and operational impact of projects performed on the oilfield. The method may also involve developing an oilfield plan based on the integrated oilfield analysis and implementing the oilfield plan.

摘要翻译： 提供了一种对具有储存器的地层的油田进行油田作业的方法。 该方法包括根据业务投入产生对油田的业务分析，根据运营投入产生对油田的运营分析，并将业务分析与运营分析结合使用作为至少部分业务的运营成果进行选择性整合 输入和使用业务输出作为至少一部分操作输入，以形成综合油田分析。 业务分析包括用于表征在油田上进行的项目的业务影响的业务输出。 操作分析包括用于描述在油田进行的项目的运行影响的运行输出。 综合油田分析包括综合油田产量，用于描述在油田进行的项目的业务和运营影响。 该方法还可能涉及基于综合油田分析和实施油田计划开发油田计划。