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1.发明申请Implants for use in brachytherapy and other radiation therapy that resist migration and rotation 失效用于近距离放射治疗和其他放射治疗的植入物，可抵抗迁移和旋转公开(公告)号：US20070021643A1
公开(公告)日：2007-01-25
申请号：US11187411
申请日：2005-07-22
申请人： Gary Lamoureux , James Matons , Warren Johnston , Matthew Bouffard , Warren Rice
发明人： Gary Lamoureux , James Matons , Warren Johnston , Matthew Bouffard , Warren Rice
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： In one embodiment a therapeutic member includes a radioactive source and a material (e.g., a bio-absorbable polymeric material) that encapsulates the radioactive source. An outer surface of the encapsulating material includes a plurality of protrusions to reduce a tendency of the member to migrate and rotate within a patient's body after implantation. In an embodiment, the encapsulating material includes an anchor mechanism that extends from at least one of the longitudinal ends of the radioactive source to reduce a tendency of the member to migrate and rotate within a patient's body after implantation. Embodiments of the present invention are also directed to strands that include similar protrusions and/or anchor mechanisms. Additionally, embodiments of the present invention are directed to spacers that resist migration and rotation. Embodiments are also directed to radiopaque markers that resist migration and rotation. This abstract is not intended to be a complete description of the invention.
摘要翻译： 在一个实施方案中，治疗构件包括放射源和封装放射源的材料（例如，生物吸收性聚合材料）。 封装材料的外表面包括多个突起，以减少在植入后患者身体内迁移和旋转的构件倾向。 在一个实施例中，封装材料包括从放射源的至少一个纵向末端延伸的锚定机构，以减少在植入后患者身体迁移和旋转的趋势。 本发明的实施例还涉及包括类似的突起和/或锚定机构的股线。 此外，本发明的实施例涉及抵抗迁移和旋转的间隔物。 实施例还涉及抵抗迁移和旋转的不透射线的标记。 本摘要并不是对本发明的完整描述。
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2.发明申请Devices to resist migration and rotation of implants used in brachytherapy and other radiation therapy 有权用于抵抗近距离放射治疗和其他放射治疗中使用的植入物的迁移和旋转的装置公开(公告)号：US20070021642A1
公开(公告)日：2007-01-25
申请号：US11489895
申请日：2006-07-20
申请人： Gary Lamoureux , James Matons , Warren Johnston , Matthew Bouffard , Warren Rice
发明人： Gary Lamoureux , James Matons , Warren Johnston , Matthew Bouffard , Warren Rice
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： An anchor mechanism includes a sleeve to fit around a structure such as a radioactive source, a thermal ablation implant, a spacer, a strand or a radiopaque marker. The sleeve has a bore that extends an entire longitudinal length of the sleeve, and through which the structure fits, such that the structure can extend out from both longitudinal ends of the sleeve. One or more protrusion extends from an outer surface of the sleeve to engage surrounding patient tissue after implantation of the structure into a patient, to thereby reduce a tendency for the structure to migrate and rotate after implantation.
摘要翻译： 锚定机构包括套筒，以适应诸如放射源，热消融植入物，间隔物，股线或不透射线标记之类的结构。 套筒具有延伸套筒的整个纵向长度的孔，并且结构配合通过该孔，使得结构可以从套筒的两个纵向端部伸出。 一个或多个突起从套筒的外表面延伸，以将结构植入病人之后接合周围的患者组织，从而减少结构在植入后迁移和旋转的趋势。
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3.发明申请IMPLANTS FOR USE IN BRACHYTHERAPY AND OTHER RADIATION THERAPY THAT RESIST MIGRATION AND ROTATION 有权用于BRACHYTHERAPY和其他辐射治疗的植入物，可抵抗移动和旋转公开(公告)号：US20090099402A1
公开(公告)日：2009-04-16
申请号：US12335435
申请日：2008-12-15
IPC分类号： A61M36/12
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： In an embodiment a therapeutic member includes a solitary radioactive seed. The seed includes a metallic housing with radioactive material contained within the metallic housing. The metallic housing has a first longitudinal end and a second longitudinal end and a longitudinal length between the first and second longitudinal ends. A polymeric material is molded to completely and monolithically encapsulate the metallic housing of the solitary radioactive seed. The implantable therapeutic member is adapted to be implanted into patient tissue using a hollow needle. A portion of the molded polymeric material extends from one of the first and second longitudinal ends of the metallic housing to reduce a tendency of the seed to migrate and rotate within a patient's body after implantation of the member. The portion of the molded polymeric material, that extends from one of the first and second longitudinal ends of the metallic housing, causes the implantable therapeutic member to have a longitudinal length that is greater than the longitudinal length of the metallic housing.
摘要翻译： 在一个实施方案中，治疗构件包括孤立的放射性种子。 种子包括金属外壳，放射性材料包含在金属外壳内。 金属壳体具有第一纵向端部和第二纵向端部以及在第一和第二纵向端部之间的纵向长度。 将聚合物材料模制成完全和整体地包封孤立的放射性种子的金属壳体。 可植入治疗构件适于使用中空针植入患者组织。 模制的聚合物材料的一部分从金属外壳的第一和第二纵向端之一延伸，以减少种植物在植入构件之后在患者体内迁移和旋转的倾向。 模制聚合物材料的从金属外壳的第一和第二纵向端之一延伸的部分使可植入治疗构件的纵向长度大于金属外壳的纵向长度。
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4.发明授权Devices to resist migration and rotation of implants used in brachytherapy and other radiation therapy 有权用于抵抗近距离放射治疗和其他放射治疗中使用的植入物的迁移和旋转的装置公开(公告)号：US08790235B2
公开(公告)日：2014-07-29
申请号：US12538028
申请日：2009-08-07
IPC分类号： A61M36/12
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle comprises a single radioactive source encapsulated by a bio-absorbable material having an outer surface including one or more ribs encircling the single radioactive source, a leading edge endcap rib and a trailing edge endcap rib. The one or more ribs reduces a tendency of the member to migrate and rotate within a patient's body after implantation. The encapsulating material further includes a first rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, and a second rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, the second rail arranged in a plane substantially perpendicular to a plane in which the first rail is arranged. Another embodiment includes wings that selectively extend from an implant preventing movement of the implant.
摘要翻译： 用于通过针可递送到植入部位的近距离放射治疗的治疗部件包括由生物可吸收材料包封的单个放射源，所述生物可吸收材料具有外表面，该外表面包括环绕单个放射源的一个或多个肋，前缘端盖肋和 后缘端盖肋。 一个或多个肋降低了植入后患者身体内迁移和旋转的倾向。 封装材料还包括由生物可吸收材料形成的第一轨道，其至少从包封材料的外表面的相对侧沿着治疗构件的纵向轴线延伸，以及由生物可吸收材料形成的第二轨道 至少从包封材料的外表面的相对侧沿着施疗件的纵向轴线，第二导轨布置成大致垂直于第一导轨布置的平面的平面。 另一个实施例包括从防止植入物移动的植入体选择性延伸的翼。
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5.发明申请IMPLANTS FOR USE IN BRACHYTHERAPY AND OTHER RADIATION THERAPY THAT RESIST MIGRATION AND ROTATION 审中-公开用于BRACHYTHERAPY和其他辐射治疗的植入物，可抵抗移动和旋转公开(公告)号：US20090149692A1
公开(公告)日：2009-06-11
申请号：US12388436
申请日：2009-02-18
IPC分类号： A61M36/12
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： In an embodiment a therapeutic member includes a single radioactive seed and is adapted to be implanted into patient tissue using a hollow needle. The seed includes a metallic housing with radioactive material contained within the metallic housing. A polymeric bio-adherent and/or bio-adhesive material surrounds at least a portion the housing of the single radioactive seed. The polymeric bio-adherent and/or bio-adhesive material reduces a tendency of the member to migrate and rotate within a patient's body after implantation of the member.
摘要翻译： 在一个实施例中，治疗构件包括单个放射性种子，并且适于使用空心针将其植入患者组织。 种子包括金属外壳，放射性材料包含在金属外壳内。 聚合物生物粘附和/或生物粘合剂材料包围单个放射性种子的壳体的至少一部分。 聚合物生物粘附和/或生物粘合剂材料降低了在植入植入物之后，患者迁移并在患者体内旋转的倾向。
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6.发明申请IMPLANTS FOR USE IN BRACHYTHERAPY AND OTHER RADIATION THERAPY THAT RESIST MIGRATION AND ROTATION 有权用于BRACHYTHERAPY和其他辐射治疗的植入物，可抵抗移动和旋转公开(公告)号：US20120016176A1
公开(公告)日：2012-01-19
申请号：US13213012
申请日：2011-08-18
IPC分类号： A61M36/12
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： A therapeutic strand implant, for use in brachytherapy and deliverable to an implant site by way of a needle, includes a plurality of radioactive sources, and a polymeric material molded to encapsulate the radioactive sources. A space is defined by the polymeric material between each adjacent pair of the radioactive sources. A plurality of protrusions is defined by an outer surface of the encapsulating polymeric material.
摘要翻译： 用于近距离放射治疗并通过针可输送到植入部位的治疗股植入物包括多个放射源，以及模制成包封放射源的聚合材料。 每个相邻的放射源对之间由聚合物材料限定空间。 多个突起由封装聚合材料的外表面限定。
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7.发明授权Implants for use in brachytherapy and other radiation therapy that resist migration and rotation 失效用于近距离放射治疗和其他放射治疗的植入物，可抵抗迁移和旋转公开(公告)号：US07736293B2
公开(公告)日：2010-06-15
申请号：US11187411
申请日：2005-07-22
IPC分类号： A61M36/12
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： In one embodiment a therapeutic member includes a radioactive source and a material (e.g., a bio-absorbable polymeric material) that encapsulates the radioactive source. An outer surface of the encapsulating material includes a plurality of protrusions to reduce a tendency of the member to migrate and rotate within a patient's body after implantation. In an embodiment, the encapsulating material includes an anchor mechanism that extends from at least one of the longitudinal ends of the radioactive source to reduce a tendency of the member to migrate and rotate within a patient's body after implantation. Embodiments of the present invention are also directed to strands that include similar protrusions and/or anchor mechanisms. Additionally, embodiments of the present invention are directed to spacers that resist migration and rotation. Embodiments are also directed to radiopaque markers that resist migration and rotation. This abstract is not intended to be a complete description of the invention.
摘要翻译： 在一个实施方案中，治疗构件包括放射源和封装放射源的材料（例如，生物吸收性聚合材料）。 封装材料的外表面包括多个突起，以减少在植入后患者身体内迁移和旋转的构件倾向。 在一个实施例中，封装材料包括从放射源的至少一个纵向末端延伸的锚固机构，以减少在植入后患者身体内迁移和旋转的趋势。 本发明的实施例还涉及包括类似的突起和/或锚定机构的股线。 此外，本发明的实施例涉及抵抗迁移和旋转的间隔物。 实施例还涉及抵抗迁移和旋转的不透射线的标记。 本摘要并不是对本发明的完整描述。
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8.发明申请THERAPEUTIC MEMBER INCLUDING A RAIL TO RESIST MOVEMENT WITHIN A NEEDLE USED IN BRACHYTHERAPY AND OTHER RADIATION THERAPY 有权治疗性成员包括用于抵抗在BRACHYTHERAPY和其他辐射治疗中使用的针头中的运动的轨道公开(公告)号：US20090203953A1
公开(公告)日：2009-08-13
申请号：US12393349
申请日：2009-02-26
IPC分类号： A61M36/12
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle comprises a single radioactive source encapsulated by a bio-absorbable material having an outer surface including one or more ribs encircling the single radioactive source, a leading edge endcap rib and a trailing edge endcap rib. The one or more ribs reduces a tendency of the member to migrate and rotate within a patient's body after implantation. The encapsulating material further includes a first rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, and a second rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, the second rail arranged in a plane substantially perpendicular to a plane in which the first rail is arranged.
摘要翻译： 用于通过针可递送到植入部位的近距离放射治疗的治疗部件包括由生物可吸收材料包封的单个放射源，所述生物可吸收材料具有外表面，该外表面包括环绕单个放射源的一个或多个肋，前缘端盖肋和 后缘端盖肋。 一个或多个肋降低了植入后患者身体内迁移和旋转的倾向。 封装材料还包括由生物可吸收材料形成的第一轨道，其至少从包封材料的外表面的相对侧沿着治疗构件的纵向轴线延伸，以及由生物可吸收材料形成的第二轨道 至少从包封材料的外表面的相对侧沿着施疗件的纵向轴线，第二导轨布置成大致垂直于第一导轨布置的平面的平面。
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9.发明授权Therapeutic member including a rail used in brachytherapy and other radiation therapy 有权治疗成员包括用于近距离放射治疗和其他放射治疗的轨道公开(公告)号：US08187159B2
公开(公告)日：2012-05-29
申请号：US12393349
申请日：2009-02-26
IPC分类号： A61M36/00
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle comprises a single radioactive source encapsulated by a bio-absorbable material having an outer surface including one or more ribs encircling the single radioactive source, a leading edge endcap rib and a trailing edge endcap rib. The one or more ribs reduces a tendency of the member to migrate and rotate within a patient's body after implantation. The encapsulating material further includes a first rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, and a second rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, the second rail arranged in a plane substantially perpendicular to a plane in which the first rail is arranged.
摘要翻译： 用于通过针可递送到植入部位的近距离放射治疗的治疗部件包括由生物可吸收材料包封的单个放射源，所述生物可吸收材料具有外表面，该外表面包括环绕单个放射源的一个或多个肋，前缘端盖肋和 后缘端盖肋。 一个或多个肋降低了植入后患者身体内迁移和旋转的倾向。 封装材料还包括由生物可吸收材料形成的第一轨道，其至少从包封材料的外表面的相对侧沿着治疗构件的纵向轴线延伸，以及由生物可吸收材料形成的第二轨道 至少从包封材料的外表面的相对侧沿着施疗件的纵向轴线，第二导轨布置成大致垂直于第一导轨布置的平面的平面。
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10.发明授权Devices to resist migration and rotation of implants used in brachytherapy and other radiation therapy 有权用于抵抗近距离放射治疗和其他放射治疗中使用的植入物的迁移和旋转的装置公开(公告)号：US07972261B2
公开(公告)日：2011-07-05
申请号：US11489895
申请日：2006-07-20
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： An anchor mechanism includes a sleeve to fit around a structure such as a radioactive source, a thermal ablation implant, a spacer, a strand or a radiopaque marker. The sleeve has a bore that extends an entire longitudinal length of the sleeve, and through which the structure fits, such that the structure can extend out from both longitudinal ends of the sleeve. One or more protrusion extends from an outer surface of the sleeve to engage surrounding patient tissue after implantation of the structure into a patient, to thereby reduce a tendency for the structure to migrate and rotate after implantation.
摘要翻译： 锚定机构包括套筒，以适应诸如放射源，热消融植入物，间隔物，股线或不透射线标记之类的结构。 套筒具有延伸套筒的整个纵向长度的孔，并且结构配合通过该孔，使得结构可以从套筒的两个纵向端部伸出。 一个或多个突起从套筒的外表面延伸，以将结构植入病人之后接合周围的患者组织，从而减少结构在植入后迁移和旋转的趋势。
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