公开(公告)号：US08666506B2

公开(公告)日：2014-03-04

申请号：US11810941

申请日：2007-06-07

申请人： Gary W. King ,  Steven M. Goetz ,  Kevin K. Tidemand ,  Wilbert A. Wesselink ,  Gabriela C. Miyazawa ,  Jordan J. Greenberg

发明人： Gary W. King ,  Steven M. Goetz ,  Kevin K. Tidemand ,  Wilbert A. Wesselink ,  Gabriela C. Miyazawa ,  Jordan J. Greenberg

IPC分类号： A61N1/05

CPC分类号： A61N1/37247 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/36185 ,  G06F19/00 ,  G06F19/3481 ,  G16H40/63

摘要： Techniques for selecting electrode combinations for stimulation therapy are described. The techniques include selecting one or more electrode combinations based on information associating a plurality of electrode combinations with at least one value of a therapy metric. The therapy metric comprises a quantifiable result of delivery of stimulation, and may be generated computer modeling of delivery of stimulation via the electrode combinations. In one embodiment, a clinician may deliver stimulation via a baseline electrode combination, receive patient feedback to the baseline electrode combination, select a therapy metric based on the patient feedback, and select additional electrode combinations based on the selected therapy metric and the information associating the electrode combinations with therapy metric values. In another embodiment, the clinician may select a therapy metric prior to providing a test stimulation and select additional electrode combinations based on the selected therapy metric and the information associating electrode combinations with metric values.

摘要翻译： 描述了用于选择用于刺激治疗的电极组合的技术。 所述技术包括基于将多个电极组合与治疗度量的至少一个值相关联的信息来选择一个或多个电极组合。 治疗指标包括刺激递送的可量化结果，并且可以产生经由电极组合递送刺激的计算机建模。 在一个实施例中，临床医生可以经由基线电极组合递送刺激，将患者反馈接收到基线电极组合，基于患者反馈选择治疗度量，并且基于所选择的治疗度量选择附加电极组合，并且将关于 电极组合与治疗度量值。 在另一个实施例中，临床医生可以在提供测试刺激之前选择治疗度量，并且基于所选择的治疗度量和将电极组合与度量值相关联的信息来选择附加电极组合。

公开(公告)号：US20080004675A1

公开(公告)日：2008-01-03

申请号：US11810967

申请日：2007-06-07

申请人： Gary W. King ,  Kevin K. Tidemand ,  Wilbert A. Wesselink ,  Gabriela C. Miyazawa ,  Jordan J. Greenberg

发明人： Gary W. King ,  Kevin K. Tidemand ,  Wilbert A. Wesselink ,  Gabriela C. Miyazawa ,  Jordan J. Greenberg

IPC分类号： A61N1/05

CPC分类号： A61N1/37247 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/36185 ,  G06F19/00 ,  G06F19/3481 ,  G16H40/63

摘要： Techniques for selecting electrode combinations for stimulation therapy include delivering stimulation via each of at least two electrode combination classes during a therapy evaluation period. A first one of the classes comprises one or more electrode combinations that include electrodes within one or two columns of an implantable array of electrodes. The array may include at least three electrode columns. A second one of the classes comprises one or more electrode combinations that include electrodes within at least three electrode columns of the implantable array of electrodes. A preferred one of the electrode combination classes for a patient, and/or a number of leads to implant within the patient, may by selected based on feedback collected from the patient during the therapy evaluation period.

摘要翻译： 用于选择用于刺激治疗的电极组合的技术包括在治疗评价期间通过至少两个电极组合类别中的每一个递送刺激。 这些类别中的第一个包括一个或多个电极组合，其包括在可植入的电极阵列的一列或两列内的电极。 阵列可以包括至少三个电极柱。 第二类包括一个或多个电极组合，其包括在可植入电极阵列的至少三个电极列内的电极。 可以通过基于在治疗评估期间从患者收集的反馈来选择用于患者的电极组合类别中的优选的一个，和/或患者内的植入物的数量。

公开(公告)号：US08744597B2

公开(公告)日：2014-06-03

申请号：US11810967

申请日：2007-06-07

申请人： Gary W. King ,  Kevin K. Tidemand ,  Wilbert A. Wesselink ,  Gabriela C. Miyazawa ,  Jordan J. Greenberg

发明人： Gary W. King ,  Kevin K. Tidemand ,  Wilbert A. Wesselink ,  Gabriela C. Miyazawa ,  Jordan J. Greenberg

IPC分类号： A61N1/05

CPC分类号： A61N1/37247 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/36185 ,  G06F19/00 ,  G06F19/3481 ,  G16H40/63

摘要： Techniques for selecting electrode combinations for stimulation therapy include delivering stimulation via each of at least two electrode combination classes during a therapy evaluation period. A first one of the classes comprises one or more electrode combinations that include electrodes within one or two columns of an implantable array of electrodes. The array may include at least three electrode columns. A second one of the classes comprises one or more electrode combinations that include electrodes within at least three electrode columns of the implantable array of electrodes. A preferred one of the electrode combination classes for a patient, and/or a number of leads to implant within the patient, may by selected based on feedback collected from the patient during the therapy evaluation period.

摘要翻译： 用于选择用于刺激治疗的电极组合的技术包括在治疗评价期间通过至少两个电极组合类别中的每一个递送刺激。 这些类别中的第一个包括一个或多个电极组合，其包括在可植入的电极阵列的一列或两列内的电极。 阵列可以包括至少三个电极柱。 第二类包括一个或多个电极组合，其包括在可植入电极阵列的至少三个电极列内的电极。 可以通过基于在治疗评估期间从患者收集的反馈来选择用于患者的电极组合类别中的优选的一个，和/或患者内的植入物的数量。

公开(公告)号：US20120158098A1

公开(公告)日：2012-06-21

申请号：US13403288

申请日：2012-02-23

申请人： Wilbert A. Wesselink

发明人： Wilbert A. Wesselink

IPC分类号： A61N1/08

CPC分类号： A61N1/36135 ,  A61B5/107 ,  A61B5/1118 ,  A61B5/6886 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/36071 ,  A61N1/36542

摘要： The disclosure describes a system that measures the distance between one or more electrodes and tissue of a patient, and controls one or more parameters of the stimulation delivered to the tissue by the electrodes based on the measured distance. The system controls the measurement of the distance between the electrodes and the tissue as a function of activity of the patient. The system uses, for example, a piezoelectric transducer to sense activity of the patient, and may determine whether or how frequently to measure the distance between electrodes and tissue based on the sensed physical activity. A piezoelectric transducer may be used both to sense activity and to measure the distance between the electrodes and the tissue.

摘要翻译： 本公开描述了一种系统，其测量患者的一个或多个电极和组织之间的距离，并且基于测量的距离控制由电极传递到组织的刺激的一个或多个参数。 系统控制电极和组织之间的距离的测量作为患者活动的函数。 该系统使用例如压电换能器来感测患者的活动，并且可以基于感测到的身体活动来确定是否或多少频率地测量电极和组织之间的距离。 可以使用压电换能器来感测活动并测量电极和组织之间的距离。

公开(公告)号：US07406351B2

公开(公告)日：2008-07-29

申请号：US11116969

申请日：2005-04-28

申请人： Wilbert A. Wesselink

发明人： Wilbert A. Wesselink

IPC分类号： A61B5/103 ,  A61B5/117

CPC分类号： A61N1/36135 ,  A61B5/107 ,  A61B5/1118 ,  A61B5/6886 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/36071 ,  A61N1/36542

摘要： The disclosure describes a system that measures the distance between one or more electrodes and tissue of a patient, and controls one or more parameters of the stimulation delivered to the tissue by the electrodes based on the measured distance. The system controls the measurement of the distance between the electrodes and the tissue as a function of activity of the patient. The system uses, for example, a piezoelectric transducer to sense activity of the patient, and may determine whether or how frequently to measure the distance between electrodes and tissue based on the sensed physical activity. A piezoelectric transducer may be used both to sense activity and to measure the distance between the electrodes and the tissue.

摘要翻译： 本公开描述了一种系统，其测量患者的一个或多个电极和组织之间的距离，并且基于测量的距离控制由电极传递到组织的刺激的一个或多个参数。 系统控制电极和组织之间的距离的测量作为患者活动的函数。 该系统使用例如压电换能器来感测患者的活动，并且可以基于感测到的身体活动来确定是否或多少频率地测量电极和组织之间的距离。 可以使用压电换能器来感测活动并测量电极和组织之间的距离。

公开(公告)号：US08150530B2

公开(公告)日：2012-04-03

申请号：US12181047

申请日：2008-07-28

申请人： Wilbert A. Wesselink

发明人： Wilbert A. Wesselink

IPC分类号： A61B5/103 ,  A61B5/117

CPC分类号： A61N1/36135 ,  A61B5/107 ,  A61B5/1118 ,  A61B5/6886 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/36071 ,  A61N1/36542

摘要： The disclosure describes a system that measures the distance between one or more electrodes and tissue of a patient, and controls one or more parameters of the stimulation delivered to the tissue by the electrodes based on the measured distance. The system controls the measurement of the distance between the electrodes and the tissue as a function of activity of the patient. The system uses, for example, a piezoelectric transducer to sense activity of the patient, and may determine whether or how frequently to measure the distance between electrodes and tissue based on the sensed physical activity. A piezoelectric transducer may be used both to sense activity and to measure the distance between the electrodes and the tissue.

公开(公告)号：US20080281379A1

公开(公告)日：2008-11-13

申请号：US12181013

申请日：2008-07-28

申请人： Wilbert A. Wesselink

发明人： Wilbert A. Wesselink

IPC分类号： A61N1/00

CPC分类号： A61N1/36135 ,  A61B5/107 ,  A61B5/1118 ,  A61B5/6886 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/36071 ,  A61N1/36542

摘要： The disclosure describes a system that measures the distance between one or more electrodes and tissue of a patient, and controls one or more parameters of the stimulation delivered to the tissue by the electrodes based on the measured distance. The system controls the measurement of the distance between the electrodes and the tissue as a function of activity of the patient. The system uses, for example, a piezoelectric transducer to sense activity of the patient, and may determine whether or how frequently to measure the distance between electrodes and tissue based on the sensed physical activity. A piezoelectric transducer may be used both to sense activity and to measure the distance between the electrodes and the tissue.

摘要翻译： 本公开描述了一种系统，其测量患者的一个或多个电极和组织之间的距离，并且基于测量的距离控制由电极传递到组织的刺激的一个或多个参数。 系统控制电极和组织之间的距离的测量作为患者活动的函数。 该系统使用例如压电换能器来感测患者的活动，并且可以基于感测到的身体活动来确定是否或多少频率地测量电极和组织之间的距离。 可以使用压电换能器来感测活动并测量电极和组织之间的距离。

公开(公告)号：US08483839B2

公开(公告)日：2013-07-09

申请号：US13403288

申请日：2012-02-23

申请人： Wilbert A. Wesselink

发明人： Wilbert A. Wesselink

IPC分类号： A61B5/103 ,  A61B5/117

CPC分类号： A61N1/36135 ,  A61B5/107 ,  A61B5/1118 ,  A61B5/6886 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/36071 ,  A61N1/36542

摘要： The disclosure describes a system that measures the distance between one or more electrodes and tissue of a patient, and controls one or more parameters of the stimulation delivered to the tissue by the electrodes based on the measured distance. The system controls the measurement of the distance between the electrodes and the tissue as a function of activity of the patient. The system uses, for example, a piezoelectric transducer to sense activity of the patient, and may determine whether or how frequently to measure the distance between electrodes and tissue based on the sensed physical activity. A piezoelectric transducer may be used both to sense activity and to measure the distance between the electrodes and the tissue.

摘要翻译： 本公开描述了一种系统，其测量患者的一个或多个电极和组织之间的距离，并且基于测量的距离控制由电极传递到组织的刺激的一个或多个参数。 系统控制电极和组织之间的距离的测量作为患者活动的函数。 该系统使用例如压电换能器来感测患者的活动，并且可以基于感测到的身体活动来确定是否或多少频率地测量电极和组织之间的距离。 可以使用压电换能器来感测活动并测量电极和组织之间的距离。

公开(公告)号：US08155753B2

公开(公告)日：2012-04-10

申请号：US12181013

申请日：2008-07-28

申请人： Wilbert A. Wesselink

发明人： Wilbert A. Wesselink

IPC分类号： A61B5/103 ,  A61B5/117 ,  A61B8/12

CPC分类号： A61N1/36135 ,  A61B5/107 ,  A61B5/1118 ,  A61B5/6886 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/36071 ,  A61N1/36542

摘要： The disclosure describes a system that measures the distance between one or more electrodes and tissue of a patient, and controls one or more parameters of the stimulation delivered to the tissue by the electrodes based on the measured distance. The system controls the measurement of the distance between the electrodes and the tissue as a function of activity of the patient. The system uses, for example, a piezoelectric transducer to sense activity of the patient, and may determine whether or how frequently to measure the distance between electrodes and tissue based on the sensed physical activity. A piezoelectric transducer may be used both to sense activity and to measure the distance between the electrodes and the tissue.

摘要翻译： 本公开描述了一种系统，其测量患者的一个或多个电极和组织之间的距离，并且基于测量的距离控制由电极传递到组织的刺激的一个或多个参数。 系统控制电极和组织之间的距离的测量作为患者活动的函数。 该系统使用例如压电换能器来感测患者的活动，并且可以基于感测到的身体活动来确定是否或多少频率地测量电极和组织之间的距离。 可以使用压电换能器来感测活动并测量电极和组织之间的距离。

公开(公告)号：US20080288031A1

公开(公告)日：2008-11-20

申请号：US12181047

申请日：2008-07-28

申请人： Wilbert A. Wesselink

发明人： Wilbert A. Wesselink

IPC分类号： A61N1/36

CPC分类号： A61N1/36135 ,  A61B5/107 ,  A61B5/1118 ,  A61B5/6886 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0553 ,  A61N1/36071 ,  A61N1/36542

摘要： The disclosure describes a system that measures the distance between one or more electrodes and tissue of a patient, and controls one or more parameters of the stimulation delivered to the tissue by the electrodes based on the measured distance. The system controls the measurement of the distance between the electrodes and the tissue as a function of activity of the patient. The system uses, for example, a piezoelectric transducer to sense activity of the patient, and may determine whether or how frequently to measure the distance between electrodes and tissue based on the sensed physical activity. A piezoelectric transducer may be used both to sense activity and to measure the distance between the electrodes and the tissue.