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    Polymorph of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt
    3.
    发明申请
    Polymorph of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt 审中-公开
    5- [4- [2-（N-甲基-N-（2-吡啶基）氨基）乙氧基]苄基]噻唑烷-2,4-二酮，马来酸盐的多晶型物

    公开(公告)号：US20050080114A1

    公开(公告)日：2005-04-14

    申请号：US10935939

    申请日：2004-09-08

    申请人： Paul Blackler ,  Christine Browne ,  Timothy Coakley ,  Robert Giles ,  Gillian Morrissey

    发明人： Paul Blackler ,  Christine Browne ,  Timothy Coakley ,  Robert Giles ,  Gillian Morrissey

    IPC分类号： A61K20060101 ,  A61K31/00 ,  A61K31/4439 ,  A61P20060101 ,  A61P3/10 ,  C07D20060101 ,  C07D417/12 ,  C07D417/02

    CPC分类号： C07D417/12

    摘要： A polymorphic form of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt (the “Polymorph”) characterized in that it provides: (i) an infra red spectrum containing peaks at 1763, 912, 856 and 709 cm−1; and/or (ii) a Raman spectrum containing peaks at 1762, 1284, 912 and 888 cm−1; and/or (iii) a solid-state 13C nuclear magnetic resonance spectrum containing peaks at 111.0, 113.6, 119.8, 129.1, 130.9, 131.8, 134.7, 138.7, 146.5, 152.7, 157.5, 169.5, 171.0, 178.7 ppm; and/or (iv) an X-ray powder diffraction (XRPD) pattern which gives calculated lattice spacings at 5.87, 5.30, 4.69, 4.09, 3.88, 3.61, 3.53, and 3.46 Angstroms; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.

    摘要翻译： 5- [4- [2-（N-甲基-N-（2-吡啶基）氨基）乙氧基]苄基]噻唑烷-2,4-二酮，马来酸盐（“多晶型”）的多晶形式，其特征在于 它提供：（i）在1763,912,856和709cm -1处含有峰的红外光谱; 和/或（ii）在1762,1284,912和888cm -1处含有峰的拉曼光谱; 和/或（iii）在111.0,113.6,119.8,129.1,130.9,131.8,134.7,138.7,146.5,152.7,157.5,169.5,171.0,178.7ppm处含有峰的固态13 C核磁共振光谱; 和/或（iv）在5.87,5.30,4.69,4.09,3.88,3.61,3.53和3.46埃处给出计算的晶格间距的X射线粉末衍射（XRPD）图案; 制备这种化合物的方法，含有这种化合物的药物组合物和这种化合物在医药中的用途。

    Inkjet printing with replaceable set of ink-related components (printhead/service module/ink supply) for each color of ink
    4.
    发明授权
    Inkjet printing with replaceable set of ink-related components (printhead/service module/ink supply) for each color of ink 失效
    喷墨打印可更换的油墨相关组件（打印头/服务模块/墨水供应），用于每种颜色的墨水

    公开(公告)号：US6139135A

    公开(公告)日：2000-10-31

    申请号：US810485

    申请日：1997-03-03

    申请人： Rick Becker ,  Brian Canfield ,  Jesus Garcia ,  Doug Watson ,  Don Boutin ,  Eric Joseph Johnson ,  Robert Giles ,  Mark E. Young ,  Elizabeth Zapata ,  Felix Ruiz

    发明人： Rick Becker ,  Brian Canfield ,  Jesus Garcia ,  Doug Watson ,  Don Boutin ,  Eric Joseph Johnson ,  Robert Giles ,  Mark E. Young ,  Elizabeth Zapata ,  Felix Ruiz

    IPC分类号： B41J2/21 ,  B41J2/175

    CPC分类号： B41J2/17523 ,  B41J2/17509

    摘要： An inkjet printing system having a replaceable set of ink-related components which are installed together and replaced together as a single ink delivery system for each different color of ink. The set includes an ink printhead cartridge with an inlet port, an ink supply module, and a printhead service module, each of which is manually mountable by a user onto an inkjet printer. The ink supply module contains enough ink to completely replenish an entire printhead reservoir several times before the expected useful life of the printhead cartridge has expired, at which time a user can replace the entire set of ink-related components for a particular color. Similarly, the printhead service module is designed for reliable performance for the expected useful life of the printhead cartridge. This system enables the entire ink delivery system to be replaced for different printing needs, such as replacing indoor dye-based inks with outdoor pigment based inks.

    摘要翻译： 一种喷墨打印系统，其具有可替换的与油墨有关的组件的组合，它们一起安装在一起，作为用于每种不同颜色的油墨的单个油墨输送系统。 该组件包括具有入口端口的墨水打印头墨盒，墨水供应模块和打印头服务模块，每个打印头服务模块可由用户手动安装到喷墨打印机上。 墨水供应模块包含足够的墨水以在打印头墨盒的预期使用寿命期满之前多次完全补充整个打印头存储器，此时用户可以替换特定颜色的整个墨水组件。 类似地，打印头服务模块被设计为在打印头墨盒的预期使用寿命期间的可靠性能。 该系统使整个墨水输送系统可以替换为不同的打印需求，例如用室外颜料基油墨代替室内染料基油墨。

    Printer chassis construction
    5.
    发明授权
    Printer chassis construction 失效
    打印机底盘结构

    公开(公告)号：US06379064B1

    公开(公告)日：2002-04-30

    申请号：US09504049

    申请日：2000-02-14

    申请人： Robert Giles ,  Jordi Gimenez ,  Rajan Ramaswamy ,  Emilio Angulo ,  Fernando Juan ,  Ventura Caamano ,  Richard H Lewis ,  Antoni Monclus

    发明人： Robert Giles ,  Jordi Gimenez ,  Rajan Ramaswamy ,  Emilio Angulo ,  Fernando Juan ,  Ventura Caamano ,  Richard H Lewis ,  Antoni Monclus

    IPC分类号： B41J2325

    CPC分类号： B41J29/02

    摘要： To assemble a printer chassis comprising three structural aluminium beams extending between two structural sideplates, the printer carriage beam is first attached to the sideplates by means of attachment points arranged along a straight line and then the printing beam and lower beam are attached to provide a vibration- and deformation-resistant chassis relative to which all the other printer components are referenced. Slider rods are mounted on the printer carriage beam by means of screws which hold the rods against the beam to keep them straight. The screws also pass through apertures in rod supports, the apertures being sized to permit longitudinal thermal movements of the rods relative to the beam.

    摘要翻译： 为了组装包括在两个结构侧板之间延伸的三个结构铝梁的打印机底盘，打印机托架梁首先通过沿着直线布置的附接点附接到侧板，然后连接印刷梁和下梁以提供振动 - 和抗变形的底盘相对于所有其他打印机组件参考。 滑动杆通过螺钉安装在打印机托架梁上，螺钉将杆抵靠梁保持直线。 螺钉还穿过杆支撑件中的孔，孔的尺寸设定成允许杆相对于梁的纵向热运动。

    Process for the preparation of thiazolidinedione derivatives
    6.
    发明申请
    Process for the preparation of thiazolidinedione derivatives 审中-公开
    噻唑烷二酮衍生物的制备方法

    公开(公告)号：US20060106221A1

    公开(公告)日：2006-05-18

    申请号：US11326003

    申请日：2006-01-05

    申请人： Robert Giles ,  Norman Lewis ,  John Quick

    发明人： Robert Giles ,  Norman Lewis ,  John Quick

    IPC分类号： A61K31/4439 ,  C07D417/02

    CPC分类号： C07D417/12

    摘要： A process for preparing a compound of formula (I): or a tautomeric form thereof or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl group; R1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; A2 represents a benzene ring having in total up to five substituents; and n represents an integer in the range of from 2 to 6, which process comprises catalytically reducing a compound of formula (II): wherein A1, R1, A2 and n are as defined in relation to formula (I), characterised in that the reduction reaction is carried out using a hydrogen pressure above 20 psi; and thereafter if required forming a pharmaceutically acceptable salt and/or a pharmaceutically acceptable solvate of the compound of formula (I).

    摘要翻译： 制备式（I）化合物或其互变异构体或其药学上可接受的盐或其药学上可接受的溶剂合物的方法，其中：A 1表示取代或未取代的芳族杂环基 ; R 1表示氢原子，烷基，酰基，芳烷基，其中芳基部分可以是取代或未取代的，或取代或未取代的芳基; 代表一个总共有五个取代基的苯环; 并且n表示2至6的整数，该方法包括催化还原式（II）的化合物：其中A 1，R 2， SUP> 2和n如关于式（I）所定义，其特征在于还原反应使用高于20psi的氢气压力进行; 然后如果需要，形成式（I）化合物的药学上可接受的盐和/或药学上可接受的溶剂化物。

    Automatic paper cutter for large format printer
    8.
    发明授权
    Automatic paper cutter for large format printer 失效

    公开(公告)号：US06315474B1

    公开(公告)日：2001-11-13

    申请号：US09183872

    申请日：1998-10-30

    申请人： Robert Giles ,  David Hermida ,  Tony Lang

    发明人： Robert Giles ,  David Hermida ,  Tony Lang

    IPC分类号： B41J1502

    CPC分类号： B26D5/02 ,  B26D1/0006 ,  B26D1/205 ,  B26D2001/0066 ,  B41J11/001 ,  B41J11/706 ,  Y10T83/7763 ,  Y10T83/8822

    摘要： A paper cutter assembly for a printer/plotter is mounted on the printhead carriage for movement therewith to avoid separate mounting and guide structure. A cutter wheel is mounted in a housing for cam induced movement between a raised inactive position and a lower active position by engagement of a cam element carrier mounted for movement in the cutter housing with structure on the printer chassis. The printer platen has a stationary cutter bar which extends in a channel in the platen transversely of the path of paper movement and has a cutter wheel receiving well at one end of the channel into which the cutter wheel drops without contacting the platen or cutter bar at commencement of a cutting operation. Camming surfaces on the platen engage the side of a cutter drive wheel to move the cutter wheel into engagement with the cutter bar and then to raise the cutter wheel to the proper amount of operational overlap of the cutting edges as the cutter assembly moves across the paper path. The cutter wheel is moved between its inactive and active positions at one side of the media and damage to the cut edge of rollfeed media is prevented by retracting the rollfeed media edge away from the cutter bar as the cutter wheel returns to said one side of the media after a cut.

    Inkjet printing with replaceable set of ink-related components (printhead/service module/ink supply) for each color of ink
    9.
    发明授权
    Inkjet printing with replaceable set of ink-related components (printhead/service module/ink supply) for each color of ink 有权
    喷墨打印可更换的油墨相关组件（打印头/服务模块/墨水供应），用于每种颜色的墨水

    公开(公告)号：US06241347B1

    公开(公告)日：2001-06-05

    申请号：US09567839

    申请日：2000-05-09

    申请人： Rick Becker ,  Brian Canfield ,  Jesus Garcia ,  Doug Watson ,  Don Boutin ,  Eric Joseph Johnson ,  Robert Giles ,  Mark E. Young ,  Elizabeth Zapata ,  Felix Ruiz

    发明人： Rick Becker ,  Brian Canfield ,  Jesus Garcia ,  Doug Watson ,  Don Boutin ,  Eric Joseph Johnson ,  Robert Giles ,  Mark E. Young ,  Elizabeth Zapata ,  Felix Ruiz

    IPC分类号： B41J2175

    CPC分类号： B41J2/17523 ,  B41J2/17509

    摘要： An inkjet printing system having a replaceable set of ink-related components which are installed together and replaced together with a single ink delivery system for each different color of ink. The set includes an ink printhead with an inlet port, an ink supply module, and a printhead service module, each of which is manually mountable by a user onto an inkjet printer. The ink supply module contains enough ink to completely replenish an entire printhead reservoir several times before the expected useful life of the printhead has expired, at which time a user can replace the entire set of ink-related components for a particular color. Similarly, the printhead service module is designed for reliable performance for the expected useful life of the printhead. This system enables the entire ink delivery system to be replaced for different printing needs, such as replacing indoor dye-based inks with outdoor pigment based inks.

    摘要翻译： 一种喷墨打印系统，其具有可替换的与油墨相关的组件的组合，其与用于每种不同颜色的油墨的单个油墨输送系统一起安装在一起并被替换。 该组件包括具有入口端口的墨水打印头，墨水供应模块和打印头服务模块，每个打印头服务模块可由用户手动安装到喷墨打印机上。 在打印头的预期使用寿命期满之前，墨水供应模块包含足够的墨水以完全补充整个打印头容器数次，此时用户可以替换特定颜色的整个墨水相关部件。 类似地，打印头服务模块被设计为在打印头的预期使用寿命期间的可靠性能。 该系统使整个墨水输送系统可以替换为不同的打印需求，例如用室外颜料基油墨代替室内染料基油墨。