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    PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
    4.
    发明申请
    PHARMACEUTICAL COMPOSITIONS AND USE THEREOF 审中-公开
    药物组合物及其用途

    公开(公告)号：US20090069350A1

    公开(公告)日：2009-03-12

    申请号：US12272378

    申请日：2008-11-17

    申请人： Gaylen M. Zentner ,  Chung Shih ,  James C. McRea

    发明人： Gaylen M. Zentner ,  Chung Shih ,  James C. McRea

    IPC分类号： A61K31/517 ,  A61P35/00

    CPC分类号： A61K31/517 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/44

    摘要： The present invention relates to pharmaceutical compositions and dosage compositions of compounds, including injectable formulations for the parenteral delivery of such compounds into patients in need of such treatment. Also featured are methods of making and using the compositions, including methods for the treatment of neoplastic diseases.

    摘要翻译： 本发明涉及化合物的药物组合物和剂量组合物，包括用于将这些化合物胃肠外递送给需要这种治疗的患者的可注射制剂。 还特征在于制备和使用组合物的方法，包括治疗肿瘤疾病的方法。

    BIODEGRADABLE BLOCK COPOLYMERIC COMPOSITIONS FOR DRUG DELIVERY
    5.
    发明申请
    BIODEGRADABLE BLOCK COPOLYMERIC COMPOSITIONS FOR DRUG DELIVERY 有权
    用于药物递送的可生物降解的嵌段共聚物组合物

    公开(公告)号：US20090264537A1

    公开(公告)日：2009-10-22

    申请号：US12490968

    申请日：2009-06-24

    申请人： Chung Shih ,  Gaylen M. Zentner

    发明人： Chung Shih ,  Gaylen M. Zentner

    IPC分类号： A61K47/34

    CPC分类号： A61K47/34 ,  A61K9/0024 ,  A61K31/765 ,  A61K31/77 ,  A61K47/10 ,  C08G2261/126 ,  C08L71/02 ,  C08L2666/18 ,  C08L2666/02

    摘要： An improved drug delivery composition and method of use is disclosed. The composition comprises one or more biodegradable block copolymer drug carriers; and a reconstitution enhancing and enabling agent comprising polyethylene glycol (PEG), a PEG derivative or a mixture of PEG and a PEG derivative. The composition can be administered as is or after being be dissolved or rapidly reconstituted in an aqueous vehicle to afford a homogeneous solution or uniform colloidal systems.

    摘要翻译： 公开了改进的药物递送组合物和使用方法。 组合物包含一种或多种可生物降解的嵌段共聚物药物载体; 和包含聚乙二醇（PEG），PEG衍生物或PEG和PEG衍生物的混合物的重构增强和使能剂。 组合物可以按照或在被溶解或快速重构在水性载体中以提供均匀的溶液或均匀的胶体体系来施用。

    Swelling modulated polymeric drug delivery device
    6.
    发明授权
    Swelling modulated polymeric drug delivery device 失效
    开卷调制聚合物药物递送装置

    公开(公告)号：US5120548A

    公开(公告)日：1992-06-09

    申请号：US433056

    申请日：1989-11-07

    申请人： Gregory A. McClelland ,  Gaylen M. Zentner

    发明人： Gregory A. McClelland ,  Gaylen M. Zentner

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/26 ,  A61K9/28

    CPC分类号： A61K9/0004 ,  A61K9/2866

    摘要： A controlled release drug delivery device, comprised of swellable polymers, whose degree of swelling in an environment of use is controlled by swelling modulators blended within the polymers, is disclosed. The swelling modulators can include buffers, osmagents, surfactants or combinations thereof surrounded by a microporous coating or interspersed within individual matrices. The combination of controlled release swelling modulators with swellable polymers may be applied to regulate patterns of beneficial agent (typically a drug) release.

    THERAPEUTIC FORMULATIONS
    8.
    发明申请
    THERAPEUTIC FORMULATIONS 审中-公开
    治疗配方

    公开(公告)号：US20090048346A1

    公开(公告)日：2009-02-19

    申请号：US11721662

    申请日：2005-11-30

    申请人： Gaylen M. Zentner ,  Chung Shih

    发明人： Gaylen M. Zentner ,  Chung Shih

    IPC分类号： A61K31/166 ,  A61P35/00

    CPC分类号： A61K31/165

    摘要： The present invention features pharmaceutical compositions that improve the bioavailability of hydrophobic pharmaceutical agents that induce apoptosis in mammalian cells. Also featured are injectable formulations for the parenteral delivery of such hydrophobic pharmaceutical agents into patients in need of such treatment, as well as methods of making and using both the compositions and formulations, including methods for the treatment of cell proliferation or hyperproliferative diseases and disorders.

    摘要翻译： 本发明的特征在于提高诱导哺乳动物细胞凋亡的疏水性药剂的生物利用度的药物组合物。 还特征在于用于将这种疏水性药剂肠胃外输送到需要这种治疗的患者中的可注射制剂，以及制备和使用组合物和制剂的方法，包括治疗细胞增殖或过度增殖性疾病和病症的方法。

    Method for automatic dosing of drugs
    9.
    发明授权
    Method for automatic dosing of drugs 失效
    药物自动给药方法

    公开(公告)号：US5782799A

    公开(公告)日：1998-07-21

    申请号：US797296

    申请日：1997-02-07

    申请人： Stephen C. Jacobsen ,  Gaylen M. Zentner

    发明人： Stephen C. Jacobsen ,  Gaylen M. Zentner

    IPC分类号： A61D7/00 ,  A61M31/00

    CPC分类号： A61M31/002 ,  A61D7/00

    摘要： The method for automatic dosing of drugs utilizes a microdelivery device which may be implanted in or otherwise administered to an animal or human. A microdelivery device is configured to have a plurality of compartments, each containing at least one drug so that a plurality of doses of the drug(s) are held within the device. In accordance with the present invention, the microdelivery device selectively actuates the compartments to selectively release doses of the drug(s) to provide an efficacious dosing pattern. One primary function of the present invention is to release two or more pesticides in such a pattern that parasites are effectively controlled while preventing the development of tolerance to the drugs within the parasites. Preferably, the microdelivery device is programmable to effectuate the release of the drug(s) at a desired time to maintain efficacious levels of the drug while minimizing the amount of drug which must be used.

    摘要翻译： 用于药物自动给药的方法使用可以植入或以其它方式施用于动物或人的微量输送装置。 微量输送装置被配置为具有多个隔室，每个隔间包含至少一种药物，使得多个剂量的药物保持在该装置内。 根据本发明，微量输送装置选择性地致动隔室以选择性地释放药物的剂量以提供有效的给药模式。 本发明的一个主要功能是以这样的模式释放两种或更多种杀虫剂，即在有效地控制寄生虫的同时防止对寄生虫内的药物的耐受性的发展。 优选地，微量输送装置是可编程的，以在期望的时间实现药物的释放，以保持药物的有效水平，同时最小化必须使用的药物的量。

    Spheronization process using charged resins
    10.
    发明授权
    Spheronization process using charged resins 失效
    使用充电树脂的滚圆工艺

    公开(公告)号：US5350584A

    公开(公告)日：1994-09-27

    申请号：US906226

    申请日：1992-06-26

    申请人： Gregory A. McClelland ,  Gaylen M. Zentner

    发明人： Gregory A. McClelland ,  Gaylen M. Zentner

    IPC分类号： A61K9/16 ,  A61K9/18 ,  A61K47/32 ,  A61K9/14

    CPC分类号： A61K9/1694 ,  A61K9/1635

    摘要： The invention comprises a novel process for the spheronization of charged resins. Spherical multiparticlates are produced which range in size from 0.3 mm to 3 mm in diameter. The spherical particle product is microcrystalline-free. The process consists of the steps of mixing followed by wet granulation, spheronization and drying.

    摘要翻译： 本发明包括用于带电树脂的滚圆化的新方法。 产生直径范围为0.3mm至3mm的球形多极板。 球形颗粒产物是无微晶的。 该方法由以下步骤组成，然后进行湿法制粒，滚圆和干燥。