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    PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
    1.
    发明申请
    PHARMACEUTICAL COMPOSITIONS AND USE THEREOF 审中-公开
    药物组合物及其用途

    公开(公告)号：US20090069350A1

    公开(公告)日：2009-03-12

    申请号：US12272378

    申请日：2008-11-17

    申请人： Gaylen M. Zentner ,  Chung Shih ,  James C. McRea

    发明人： Gaylen M. Zentner ,  Chung Shih ,  James C. McRea

    IPC分类号： A61K31/517 ,  A61P35/00

    CPC分类号： A61K31/517 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/44

    摘要： The present invention relates to pharmaceutical compositions and dosage compositions of compounds, including injectable formulations for the parenteral delivery of such compounds into patients in need of such treatment. Also featured are methods of making and using the compositions, including methods for the treatment of neoplastic diseases.

    摘要翻译： 本发明涉及化合物的药物组合物和剂量组合物，包括用于将这些化合物胃肠外递送给需要这种治疗的患者的可注射制剂。 还特征在于制备和使用组合物的方法，包括治疗肿瘤疾病的方法。

    Selective sorbent removal system using polycation activated substrates
    6.
    发明授权
    Selective sorbent removal system using polycation activated substrates 失效
    使用聚阳离子活化底物的选择性吸附剂去除系统

    公开(公告)号：US5416198A

    公开(公告)日：1995-05-16

    申请号：US013967

    申请日：1993-02-05

    申请人： Christopher G. Anderson ,  James C. McRea

    发明人： Christopher G. Anderson ,  James C. McRea

    IPC分类号： B01J20/32 ,  C07K17/00 ,  C08G69/10 ,  B01D61/00 ,  B01D15/08 ,  B01D63/02 ,  C07H1/00

    CPC分类号： C07K17/00 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3227 ,  B01J20/3272 ,  C08G69/10

    摘要： A polycationic system for the removal of polyanions from a fluid medium is formed by, first, activating a biocompatible hydroxylated support with an organic sulfonyl chloride, such as p-toluene-sulfonyl chloride, in the presence of a dialkylamino pyridine activation catalyst, such as 4-dimethylamino-pyridine (DMAP). The activated support is then reacted with a polymer having a polyamide backbone with pendent alkyl amine groups, such as poly-L-lysine (PLL), to form C--N bonds between an activated carbon from the hydroxylated polymer and an amine group from the polymeric polyamide. Finally, any unreacted activated sites on the hydroxylated polymer are capped or removed with an effective amount of capping agent such as a mercapto (--SH), hydroxy (--OH) or amino (--NH.sub.2) containing compound which reacts with the unreacted activated sites. The pendent alkyl amines on the polyamide backbone exist, at the appropriate pH, as polycations. The polyanion, such as heparin, is removed from fluids, such as blood plasma and whole blood, by bringing these fluids in contact with the polycationic system. The polyanion is bound to the polycation system by ionic attraction. The polyanion can then be released from the polycation system by treatment with a basic solution, thereby allowing the system to be reused.

    摘要翻译： 通过首先在二烷基氨基吡啶活化催化剂存在下，用有机磺酰氯如对甲苯磺酰氯活化与生物相容的羟基化载体，形成用于从流体介质中除去聚阴离子的聚阳离子体系， 4-二甲基氨基 - 吡啶（DMAP）。 然后将活化的载体与具有聚酰胺主链的聚合物主链与悬浮的烷基胺基例如聚-L-赖氨酸（PLL）反应，以在羟基化聚合物的活性炭和来自聚合物聚酰胺的胺基之间形成CN键 。 最后，用羟基化聚合物上的任何未反应的活化部位用有效量的封端剂如巯基（-SH），羟基（-OH）或含氨基（-NH 2）的化合物进行封端或除去，该化合物与未反应的活化部位反应 。 聚酰胺主链上的侧链烷基胺在适当的pH下作为聚阳离子存在。 通过使这些流体与聚阳离子系统接触，聚阴离子如肝素从流体（例如血浆和全血）中除去。 聚阴离子通过离子吸附结合聚阳离子体系。 然后可以通过用碱性溶液处理从聚阳离子体系释放聚阴离子，从而允许系统重复使用。

    Plasma filter sorbent system for removal of components from blood
    7.
    发明授权
    Plasma filter sorbent system for removal of components from blood 失效
    用于从血液中去除组分的等离子体过滤器分离系统

    公开(公告)号：US5211850A

    公开(公告)日：1993-05-18

    申请号：US736405

    申请日：1991-07-26

    申请人： Udipi Shettigar ,  James C. McRea

    发明人： Udipi Shettigar ,  James C. McRea

    IPC分类号： A61M1/34 ,  B01D61/14 ,  B01D63/02

    CPC分类号： B01D61/145 ,  A61M1/3472 ,  A61M1/3475 ,  A61M1/3486 ,  B01D63/02 ,  B01D63/024 ,  B01D2313/40 ,  B01D2315/06 ,  Y10T436/255

    摘要： A system and method of achieving both convective and diffusive transport of plasma across a membrane accompanied by the selective removal of plasma components using sorbents followed by reinfusion of the purified plasma in a blood circulation system is achieved by pumping blood through a filter comprising a bundle of "U" shaped hollow fibers immersed in a closed plasma chamber containing sorbents in an electrolyte solution. As blood flows through the entry arm, due to positive transmembrane pressure difference, plasma filtration into the plasma chamber occurs. The entering plasma causes an increase in the chamber pressure but does not exceed the pressure in the entry arm. The increase in chamber pressure exceeds the pressure in the exit arm of filter where the transmembrane pressure difference is negative and the direction of filtration reverses causing reverse filtration/reinfusion of plasma from the chamber into the blood in the exit arm. The phenomena of positive and reverse filtration from the hollow fiber filter establishes the circulation of plasma fluid in the plasma chamber. The plasma filtering through the entry arm, which corresponds to the arterial end of the system, passes through the plasma chamber solution containing the sorbents where plasma components get selectively depleted. The sorbents may be in any usable form which are not permeable to the filter. The purified plasma reenters the filter along the exit arm corresponding to the venous end where negative transmembrane pressure exists.

    摘要翻译： 通过使用吸附剂选择性除去血浆成分，随后在血液循环系统中再次输注纯化的血浆，实现等离子体跨越膜的对流和扩散输送的系统和方法，其通过将血液通过包含一束 “U”形中空纤维浸入电解质溶液中含有吸附剂的封闭等离子体室中。 当血液流过入口臂时，由于正跨膜压力差，等离子体过滤进入等离子体室。 进入的等离子体引起室压力的增加，但不超过入口臂中的压力。 腔室压力的增加超过了过滤器出口臂的压力，其中跨膜压力差为负，并且过滤反向的方向反转，导致血浆从腔室到出口臂中的血液的反向过滤/再输注。 中空纤维过滤器的正反过滤现象使等离子体腔中的等离子流体循环。 通过进入臂的等离子体过滤，其对应于系统的动脉端，通过含有吸附剂的等离子体室溶液，其中等离子体组分被选择性地耗尽。 吸附剂可以是不能过滤器渗透的任何可用形式。 纯化的血浆沿着对应于存在负跨膜压力的静脉端的出口臂重新进入过滤器。

    Removable stylet for retrograde cardioplegia catheter and methods for use
    10.
    发明授权
    Removable stylet for retrograde cardioplegia catheter and methods for use 失效
    用于逆行心麻痹导管的可移动探针及其使用方法

    公开(公告)号：US5226427A

    公开(公告)日：1993-07-13

    申请号：US710720

    申请日：1991-06-04

    申请人： Gerald D. Buckberg ,  James C. McRea ,  Robert J. Todd

    发明人： Gerald D. Buckberg ,  James C. McRea ,  Robert J. Todd

    IPC分类号： A61F2/958 ,  A61M25/00

    CPC分类号： A61M25/1002 ,  A61M2025/1086 ,  A61M25/0075 ,  A61M25/1027

    摘要： This invention relates to a stylet for use with a retrograde cardioplegia catheter and its methods of use. The stylet includes a stylet rod, a handle on the proximal end of the stylet rod and a predetermined curve in the distal end of the stylet rod. The handle has a thumb rest on the proximal end and a one or two finger loops extending outward from the handle. An obturator is located on the distal end of the predetermined curve to impede blood flow through a tip of the cardioplegia catheter during insertion of the catheter. The invention also contemplates methods for using the stylet.

    摘要翻译： 本发明涉及一种用于逆行心麻痹导管及其使用方法的探针。 探针包括一个探针杆，在通孔针杆的近端上的手柄以及在探针杆远端的预定曲线。 手柄在近端具有拇指放置，以及从手柄向外延伸的一个或两个手指环。 闭塞器位于预定曲线的远端，以阻止在插入导管期间通过心麻痹导管的尖端的血液流动。 本发明还考虑了使用探针的方法。