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公开(公告)号：US09284543B2
公开(公告)日：2016-03-15
申请号：US13385527
申请日：2012-02-21
CPC分类号： C12N9/2408 , A61K38/00 , A61K47/60 , A61K47/61 , A61K47/6435 , C12N9/2474
摘要： Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.
摘要翻译： 提供可溶性PH20多肽，包括延长的可溶性PH20多肽及其应用。 还提供了其它C末端截短的PH20多肽和部分去糖基化的PH20多肽及其用途。
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公开(公告)号：US08927249B2
公开(公告)日：2015-01-06
申请号：US12653245
申请日：2009-12-09
CPC分类号： C12N9/2408 , A61K38/00 , A61K47/60 , A61K47/61 , A61K47/6435 , C12N9/2474
摘要： Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.
摘要翻译： 提供可溶性PH20多肽，包括延长的可溶性PH20多肽及其应用。 还提供了其它C末端截短的PH20多肽和部分去糖基化的PH20多肽及其用途。
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公开(公告)号：US20130101577A9
公开(公告)日：2013-04-25
申请号：US13385527
申请日：2012-02-21
IPC分类号： A61K38/47 , C12N9/96 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C12N1/15 , C12N15/56 , A61P25/00 , A61P35/00 , A61P27/02 , A61P9/00 , A61P29/00 , A61P9/12 , A61P31/10 , A61P33/04 , A61P31/00 , A61P25/16 , A61K39/395 , A61P33/06 , C12N9/26
CPC分类号： C12N9/2408 , A61K38/00 , A61K47/60 , A61K47/61 , A61K47/6435 , C12N9/2474
摘要： Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.
摘要翻译： 提供可溶性PH20多肽，包括延长的可溶性PH20多肽及其应用。 还提供了其它C末端截短的PH20多肽和部分去糖基化的PH20多肽及其用途。
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公开(公告)号：US20120213767A1
公开(公告)日：2012-08-23
申请号：US13385527
申请日：2012-02-21
IPC分类号： A61K38/47 , C12N9/96 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C12N1/15 , C12N15/56 , A61P25/00 , A61P35/00 , A61P27/02 , A61P9/00 , A61P29/00 , A61P9/12 , A61P31/10 , A61P33/04 , A61P31/00 , A61P25/16 , A61K39/395 , A61P33/06 , C12N9/26
CPC分类号： C12N9/2408 , A61K38/00 , A61K47/60 , A61K47/61 , A61K47/6435 , C12N9/2474
摘要： Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.
摘要翻译： 提供可溶性PH20多肽，包括延长的可溶性PH20多肽及其应用。 还提供了其它C末端截短的PH20多肽和部分去糖基化的PH20多肽及其用途。
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公开(公告)号：US20100143457A1
公开(公告)日：2010-06-10
申请号：US12653245
申请日：2009-12-09
IPC分类号： A61K38/47 , C12N9/26 , C12N9/96 , C07H21/04 , C12N15/63 , C12N5/10 , A61K39/395 , A61K9/127 , A61K38/20 , A61K38/21 , A61P35/00
CPC分类号： C12N9/2408 , A61K38/00 , A61K47/60 , A61K47/61 , A61K47/6435 , C12N9/2474
摘要： Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.
摘要翻译： 提供可溶性PH20多肽，包括延长的可溶性PH20多肽及其应用。 还提供了其它C末端截短的PH20多肽和部分去糖基化的PH20多肽及其用途。
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公开(公告)号：US20140199282A1
公开(公告)日：2014-07-17
申请号：US13999454
申请日：2014-02-26
CPC分类号： A61K38/47 , A61K9/0048 , A61K38/00 , A61K39/395 , A61K47/48215 , A61K2039/505 , C12N9/2474 , C12Y302/01035 , Y02A50/475
摘要： Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. Sialated and pegylated forms of the sHASEGPs also are provided. Methods of treatment by administering sHASEGPs and modified forms thereof also are provided.
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7.发明授权Methods for treating edema by administering a Soluble Hyaluronidase Glycoprotein (sHASEGP) 有权通过施用可溶性透明质酸糖蛋白（sHASEGP）治疗水肿的方法公开(公告)号：US08765685B2
公开(公告)日：2014-07-01
申请号：US13506783
申请日：2012-05-16
CPC分类号： A61K38/47 , A61K9/0048 , A61K38/00 , A61K39/395 , A61K47/48215 , A61K2039/505 , C12N9/2474 , C12Y302/01035 , Y02A50/475
摘要： Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. Sialated and pegylated forms of the sHASEGPs also are provided. Methods of treatment by administering sHASEGPs and modified forms thereof also are provided.
摘要翻译： 提供可溶性中性活性透明质酸酶糖蛋白（sHASEGP），其制备方法及其用于促进其它分子的给药或减轻糖胺聚糖相关病理学的用途。 描述了可溶性中性活性sHASEGP结构域的微活性多肽结构域，其包括功能性中性活性透明质酸酶结构域所需的天冬酰胺连接的糖部分。 包括改进的氨基末端前导肽，其增强sHASEGP的分泌。 还提供了sHASEGP的唾液酸化和聚乙二醇化形式。 还提供了通过施用sHASEGP的治疗方法及其修饰形式。
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8.发明授权公开(公告)号：US07846431B2
公开(公告)日：2010-12-07
申请号：US12660869
申请日：2010-03-04
CPC分类号： A61K38/47 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C12N9/2408 , C12Y302/01035 , A61K2300/00
摘要： The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated form of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
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9.发明申请公开(公告)号：US20100284995A1
公开(公告)日：2010-11-11
申请号：US12660894
申请日：2010-03-05
申请人： Louis Bookbinder , Gregory I. Frost , Gilbert Keller , Gerhard Johann Frey , Hwai Wen Chang , Jay Milton Short
发明人： Louis Bookbinder , Gregory I. Frost , Gilbert Keller , Gerhard Johann Frey , Hwai Wen Chang , Jay Milton Short
IPC分类号： A61K38/48 , A61K38/47 , A61P17/02 , A61P19/00 , A61P17/00 , C12N9/50 , C12N9/96 , C07H21/04 , C12N15/63 , C12N5/10
CPC分类号： C12N9/6491 , A61K38/4886 , C12Y304/24007
摘要： Provided are modified matrix metalloprotease (MMP) enzymes that exhibit temperature-dependent activity and uses thereof. The MMPs can be used, for example, to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.
摘要翻译： 提供了显示温度依赖性活性及其用途的修饰的基质金属蛋白酶（MMP）酶。 MMP可用于例如治疗ECM介导的疾病或特征在于增加一种或多种ECM组分的沉积或积累的疾病。
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公开(公告)号：US08431380B2
公开(公告)日：2013-04-30
申请号：US12378984
申请日：2009-02-20
IPC分类号： C12N9/26 , A61K38/47 , C12P21/02 , C07K14/435
CPC分类号： A61K38/47 , A61K9/0048 , A61K38/00 , A61K39/395 , A61K47/48215 , A61K2039/505 , C12N9/2474 , C12Y302/01035 , Y02A50/475
摘要： The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
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