公开(公告)号：US08946128B2

公开(公告)日：2015-02-03

申请号：US13201334

申请日：2010-02-24

Applicant: Geir Åge Løset

Inventor： Geir Åge Løset

IPC: C40B40/08 ,  C12N15/10

CPC classification number: C12N15/1037

Abstract: The present invention provides an alternative scaffold for peptides displayed on filamentous phages through novel fusion proteins primarily originating from pIX. Libraries of filamentous phages can be created from fusion proteins, and a phage display system comprising a phagemid and a helper phage is a part of the invention. An aspect of the invention is a kit containing a phage display system comprising a phagemid that contains a nucleic acid encoding the fusion protein of the invention and a helper phage.

Abstract translation: 本发明通过主要来自pIX的新型融合蛋白提供了在丝状噬菌体上显示的肽的替代性支架。 丝状噬菌体的文库可由融合蛋白产生，包含噬菌粒和辅助噬菌体的噬菌体展示系统是本发明的一部分。 本发明的一个方面是含有噬菌体展示系统的试剂盒，其包含含有编码本发明的融合蛋白的核酸和辅助噬菌体的噬菌粒。

公开(公告)号：US08735330B2

公开(公告)日：2014-05-27

申请号：US12673649

申请日：2008-08-20

Applicant: Geir Åge Løset

Inventor： Geir Åge Løset

IPC: C40B40/08

CPC classification number: C12N15/1037 ,  C07K14/005 ,  C07K2319/20 ,  C12N2795/14122

Abstract: The present invention provides an alternative scaffold for peptides displayed on filamentous phages through novel fusion proteins primarily originating from pVII. Libraries of filamentous phages can be created from fusion proteins, and a phage display system comprising a phagemid and a helper phage is a part of the invention. An aspect of the invention is a kit containing a phage display system comprising a phagemid and a helper phage that contains a nucleic acid encoding the fusion protein of the invention.

Abstract translation: 本发明提供了通过主要来自pVII的新型融合蛋白在丝状噬菌体上显示的肽的替代支架。 丝状噬菌体的文库可由融合蛋白产生，包含噬菌粒和辅助噬菌体的噬菌体展示系统是本发明的一部分。 本发明的一个方面是包含噬菌体展示系统的试剂盒，其包含噬菌粒和包含编码本发明的融合蛋白的核酸的辅助噬菌体。