公开(公告)号：US20150329834A1

公开(公告)日：2015-11-19

申请号：US14817910

申请日：2015-08-04

Applicant: GenVec, Inc.

Inventor： Jason Gall ,  Douglas Brough ,  Christoph Kahl ,  Duncan McVey

IPC: C12N7/00

CPC classification number: C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10352

Abstract: The invention provides methods for propagating a monkey adenovirus in a cell, including a human cell, comprising one or more gene products isolated from a human adenovirus. Also provided are methods for propagating wherein the monkey adenovirus comprises a nucleic acid sequence encoding a human adenovirus gene product. The invention further provides a monkey adenovirus, including a replication-deficient monkey adenovirus, obtained by such propagation methods.

Abstract translation: 本发明提供了在细胞中繁殖猴腺病毒的方法，包括人细胞，其包含从人腺病毒分离的一种或多种基因产物。 还提供了用于繁殖的方法，其中猴腺病毒包含编码人腺病毒基因产物的核酸序列。 本发明还提供了通过这种繁殖方法获得的猴腺病毒，其包括复制缺陷型猴腺病毒。

公开(公告)号：US09586998B2

公开(公告)日：2017-03-07

申请号：US14817910

申请日：2015-08-04

Applicant: GenVec, Inc.

Inventor： Jason Gall ,  Douglas Brough ,  Christoph Kahl ,  Duncan McVey

IPC: C07K14/005 ,  C12N15/86 ,  C12N7/00

CPC classification number: C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10352

Abstract: The invention provides methods for propagating a monkey adenovirus in a cell, including a human cell, comprising one or more gene products isolated from a human adenovirus. Also provided are methods for propagating wherein the monkey adenovirus comprises a nucleic acid sequence encoding a human adenovirus gene product. The invention further provides a monkey adenovirus, including a replication-deficient monkey adenovirus, obtained by such propagation methods.

Abstract translation: 本发明提供了在细胞中繁殖猴腺病毒的方法，包括人细胞，其包含从人腺病毒分离的一种或多种基因产物。 还提供了用于繁殖的方法，其中猴腺病毒包含编码人腺病毒基因产物的核酸序列。 本发明还提供了通过这种繁殖方法获得的猴腺病毒，其包括复制缺陷型猴腺病毒。