公开(公告)号：US20020019041A1

公开(公告)日：2002-02-14

申请号：US09870920

申请日：2001-05-31

Applicant: GenVec, Inc.

Inventor： Imre Kovesdi ,  Stephen C. Ransom

IPC: A61K039/235 ,  C12N007/01

CPC classification number: C12N15/86 ,  A61K47/183 ,  A61K47/26 ,  A61K47/32 ,  A61K48/0091 ,  C12N2710/10343 ,  C12N2710/10351

Abstract: The present invention provides a method and a composition for preserving a virus. The virus is placed in a liquid carrier with a stabilizing agent selected from the group consisting of polysorbate 80, L-arginine, polyvinylpyrrolidone, trehalose, and combinations thereof. The liquid composition can be maintained at a temperature above 0null C. for a significant period of time while maintaining a satisfactory degree of viral activity.

Abstract translation: 本发明提供了用于保存病毒的方法和组合物。 将病毒置于具有选自聚山梨醇酯80，L-精氨酸，聚乙烯吡咯烷酮，海藻糖及其组合的稳定剂的液体载体中。 液体组合物可以在高于0℃的温度下保持相当长的一段时间，同时保持令人满意的病毒活性程度。

公开(公告)号：US20030153065A1

公开(公告)日：2003-08-14

申请号：US10046517

申请日：2002-01-14

Applicant: GenVec, Inc.

Inventor： Imre Kovesdi ,  Stephen C. Ransom

IPC: C12N007/01

CPC classification number: C12N7/00 ,  C12N2710/10351

Abstract: The invention provides a composition and a method for preserving a non-enveloped viral vector. The composition comprises (a) trehalose, (b) a divalent metal salt, a cationic polymer, or a combination thereof, (c) a multiplicity of non-enveloped viral vector particles, and (d) a liquid carrier. Non-enveloped virus particles are stable in the composition in a liquid form, at elevated temperatures, for a sustained period of time.

Abstract translation: 本发明提供了一种用于保存非包膜病毒载体的组合物和方法。 组合物包含（a）海藻糖，（b）二价金属盐，阳离子聚合物或其组合，（c）多个非包膜病毒载体颗粒，和（d）液体载体。 无包膜的病毒颗粒在液体形式的组合物中在高温下持续持续一段时间是稳定的。