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公开(公告)号:US20250115618A1
公开(公告)日:2025-04-10
申请号:US18988433
申请日:2024-12-19
Applicant: Genentech, Inc.
Inventor: Christopher MCBRIDE , Lynnie Lin TRZOSS , Amogh BOLOOR , Nadezda V. SOKOLOVA , Richard M. PASTOR , Steven Thomas STABEN , Craig STIVALA , Matthew VOLGRAF , Sarah M. BRONNER
IPC: C07D498/04 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , C07D231/18 , C07D471/04 , C07D487/04 , C07D513/04
Abstract: The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.
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公开(公告)号:US20210253596A1
公开(公告)日:2021-08-19
申请号:US17150349
申请日:2021-01-15
Applicant: Genentech, Inc.
Inventor: Christopher MCBRIDE , Lynnie Lin TRZOSS , Amogh BOLOOR , Nadezda V. SOKOLOVA , Richard M. PASTOR , Steven Thomas STABEN , Craig STIVALA , Matthew VOLGRAF , Sarah M. BRONNER
IPC: C07D498/04 , C07D231/18 , C07D471/04 , C07D487/04 , C07D513/04 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/16 , A61P31/14
Abstract: The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.
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