公开(公告)号：US20250115618A1

公开(公告)日：2025-04-10

申请号：US18988433

申请日：2024-12-19

Applicant: Genentech, Inc.

Inventor： Christopher MCBRIDE ,  Lynnie Lin TRZOSS ,  Amogh BOLOOR ,  Nadezda V. SOKOLOVA ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Matthew VOLGRAF ,  Sarah M. BRONNER

IPC: C07D498/04 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07D231/18 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US20220306649A1

公开(公告)日：2022-09-29

申请号：US17686183

申请日：2022-03-03

Applicant: Genentech, Inc.

Inventor： Jeffrey A. STAFFORD ,  James M. VEAL ,  Lynnie Lin TRZOSS ,  Christopher MCBRIDE

IPC: C07D498/04 ,  A61P37/02

Abstract: The present disclosure relates to novel sulfonylurea and sulfonyl thiourea compounds and related compounds and their use in treating a disease or condition responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US20210261568A1

公开(公告)日：2021-08-26

申请号：US17150380

申请日：2021-01-15

Applicant: Genentech, Inc.

Inventor： Jeffrey A. STAFFORD ,  James M. VEAL ,  Lynnie Lin TRZOSS ,  Christopher MCBRIDE ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Matthew VOLGRAF

IPC: C07D498/04

Abstract: The present disclosure relates to novel sulfonylurea compounds and related compounds useful in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US20210395268A1

公开(公告)日：2021-12-23

申请号：US17157749

申请日：2021-01-25

Applicant: Genentech, Inc.

Inventor： Jeffrey A. STAFFORD ,  James M. VEAL ,  Lynnie Lin TRZOSS ,  Christopher MCBRIDE

IPC: C07D498/04 ,  A61P37/02

Abstract: The present disclosure relates to novel sulfonylurea and sulfonyl thiourea compounds and related compounds and their use in treating a disease or condition responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US20210253596A1

公开(公告)日：2021-08-19

申请号：US17150349

申请日：2021-01-15

Applicant: Genentech, Inc.

Inventor： Christopher MCBRIDE ,  Lynnie Lin TRZOSS ,  Amogh BOLOOR ,  Nadezda V. SOKOLOVA ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Matthew VOLGRAF ,  Sarah M. BRONNER

IPC: C07D498/04 ,  C07D231/18 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P31/16 ,  A61P31/14

Abstract: The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US20190337965A1

公开(公告)日：2019-11-07

申请号：US16513621

申请日：2019-07-16

Applicant: Genentech, Inc.

Inventor： Jeffrey A. STAFFORD ,  James M. VEAL ,  Lynnie Lin TRZOSS ,  Christopher MCBRIDE

IPC: C07D498/04 ,  A61P37/02

Abstract: The present disclosure relates to novel sulfonylurea and sulfonyl thiourea compounds and related compounds and their use in treating a disease or condition responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.