公开(公告)号：US20250115618A1

公开(公告)日：2025-04-10

申请号：US18988433

申请日：2024-12-19

Applicant: Genentech, Inc.

Inventor： Christopher MCBRIDE ,  Lynnie Lin TRZOSS ,  Amogh BOLOOR ,  Nadezda V. SOKOLOVA ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Matthew VOLGRAF ,  Sarah M. BRONNER

IPC: C07D498/04 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07D231/18 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US20230025834A1

公开(公告)日：2023-01-26

申请号：US17447361

申请日：2021-09-10

Applicant: Genentech, Inc.

Inventor： Guosheng WU ,  Emily J. HANAN ,  Marie-Gabrielle BRAUN ,  Sharada S. LABADIE ,  Keira GARLAND ,  Richard M. PASTOR ,  Paul Anthony GIBBONS ,  Yuhong FU ,  Yun-Xing CHENG

IPC: C07K7/56

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20240336625A1

公开(公告)日：2024-10-10

申请号：US18580607

申请日：2022-07-15

Applicant: Genentech, Inc.

Inventor： Kwong Wah LAI ,  Christian NILEWSKI ,  Richard M. PASTOR ,  Craig STIVALA

IPC: C07D498/04 ,  A61K31/424

CPC classification number: C07D498/04 ,  A61K31/424

Abstract: Described herein are sulfonimidamide compounds, solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing. Further described herein are methods of treating a disorder in a subject in need thereof using said compounds, solvates, tautomers, or pharmaceutically acceptable salts thereof, such as NLRP3-mediated disorders.

公开(公告)号：US20210253596A1

公开(公告)日：2021-08-19

申请号：US17150349

申请日：2021-01-15

Applicant: Genentech, Inc.

Inventor： Christopher MCBRIDE ,  Lynnie Lin TRZOSS ,  Amogh BOLOOR ,  Nadezda V. SOKOLOVA ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Matthew VOLGRAF ,  Sarah M. BRONNER

IPC: C07D498/04 ,  C07D231/18 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P31/16 ,  A61P31/14

Abstract: The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US20230159555A1

公开(公告)日：2023-05-25

申请号：US17814115

申请日：2022-07-21

Applicant: Genentech, Inc.

Inventor： Paul GIBBONS ,  Kwong Wah LAI ,  Christian NILEWSKI ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Bing-Yan ZHU ,  Huifen CHEN

IPC: C07D498/04

CPC classification number: C07D498/04

Abstract: Described herein are compounds of Formula (I), Formula (I-A), and Formula (I-B),




solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing, Further described herein are methods of inhibiting NLRP3 using said compounds, and methods of and compositions useful in treating NLRP3-dependent disorders.

公开(公告)号：US20210261568A1

公开(公告)日：2021-08-26

申请号：US17150380

申请日：2021-01-15

Applicant: Genentech, Inc.

Inventor： Jeffrey A. STAFFORD ,  James M. VEAL ,  Lynnie Lin TRZOSS ,  Christopher MCBRIDE ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Matthew VOLGRAF

IPC: C07D498/04

Abstract: The present disclosure relates to novel sulfonylurea compounds and related compounds useful in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.