公开(公告)号：US20250115618A1

公开(公告)日：2025-04-10

申请号：US18988433

申请日：2024-12-19

Applicant: Genentech, Inc.

Inventor： Christopher MCBRIDE ,  Lynnie Lin TRZOSS ,  Amogh BOLOOR ,  Nadezda V. SOKOLOVA ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Matthew VOLGRAF ,  Sarah M. BRONNER

IPC: C07D498/04 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07D231/18 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US20230119740A1

公开(公告)日：2023-04-20

申请号：US17862963

申请日：2022-07-12

Applicant: GENENTECH, INC.

Inventor： Samantha Alyson GREEN ,  Jessica Marie GRANDNER ,  Steven Thomas STABEN ,  Neri AMARA ,  Vishva M. DIXIT ,  Elisia VILLEMURE

IPC: C07D498/04 ,  A61K9/20 ,  A61K9/48 ,  A61K9/08 ,  A61K47/02 ,  A61K47/10 ,  A61K9/12 ,  A61K47/12 ,  A61K47/06 ,  C07D519/00 ,  C07F9/6561

Abstract: The invention provides a compound of formula (I): or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 have any of the values described in the specification, as well as compositions comprising a compound of formula (I) or a prodrug thereof, or a pharmaceutically acceptable salt thereof. The compounds are agonists of glycolytic enzyme phosphofructokinase-1 liver type and are useful for treating diseases associated with the activity of glycolytic enzyme phosphofructokinase-1 liver type, such as cancer, diabetes, sepsis, and septic shock.

公开(公告)号：US20210253596A1

公开(公告)日：2021-08-19

申请号：US17150349

申请日：2021-01-15

Applicant: Genentech, Inc.

Inventor： Christopher MCBRIDE ,  Lynnie Lin TRZOSS ,  Amogh BOLOOR ,  Nadezda V. SOKOLOVA ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Matthew VOLGRAF ,  Sarah M. BRONNER

IPC: C07D498/04 ,  C07D231/18 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P31/16 ,  A61P31/14

Abstract: The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US20250109142A1

公开(公告)日：2025-04-03

申请号：US18657963

申请日：2024-05-08

Applicant: GENENTECH, INC.

Inventor： Samantha Alyson GREEN ,  Jessica Marie GRANDNER ,  Steven Thomas STABEN ,  Neri AMARA ,  Vishva M. DIXIT ,  Elisia VILLEMURE

IPC: C07D498/04 ,  A61K9/08 ,  A61K9/12 ,  A61K9/20 ,  A61K9/48 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  C07D519/00 ,  C07F9/6561

Abstract: The invention provides a compound of formula (I): or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 have any of the values described in the specification, as well as compositions comprising a compound of formula (I) or a prodrug thereof, or a pharmaceutically acceptable salt thereof. The compounds are agonists of glycolytic enzyme phosphofructokinase-1 liver type and are useful for treating diseases associated with the activity of glycolytic enzyme phosphofructokinase-1 liver type, such as cancer, diabetes, sepsis, and septic shock.

公开(公告)号：US20230159555A1

公开(公告)日：2023-05-25

申请号：US17814115

申请日：2022-07-21

Applicant: Genentech, Inc.

Inventor： Paul GIBBONS ,  Kwong Wah LAI ,  Christian NILEWSKI ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Bing-Yan ZHU ,  Huifen CHEN

IPC: C07D498/04

CPC classification number: C07D498/04

Abstract: Described herein are compounds of Formula (I), Formula (I-A), and Formula (I-B),




solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing, Further described herein are methods of inhibiting NLRP3 using said compounds, and methods of and compositions useful in treating NLRP3-dependent disorders.

公开(公告)号：US20210261568A1

公开(公告)日：2021-08-26

申请号：US17150380

申请日：2021-01-15

Applicant: Genentech, Inc.

Inventor： Jeffrey A. STAFFORD ,  James M. VEAL ,  Lynnie Lin TRZOSS ,  Christopher MCBRIDE ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Matthew VOLGRAF

IPC: C07D498/04

Abstract: The present disclosure relates to novel sulfonylurea compounds and related compounds useful in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.