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公开(公告)号：US20230250074A1
公开(公告)日：2023-08-10
申请号：US18164302
申请日：2023-02-03
Applicant: Genentech, Inc. , Hoffmann-La Roche Inc.
Inventor： Rene LEBL , Ngiap Kie LIM , Roland Christoph MEIER , Ugo Jonathan ORCEL , Joerg SEDELMEIER , Jeff SHEN , Lauren Elizabeth SIROIS , Jacob C. TIMMERMAN , Etienne TRACHSEL , Nicholas Andrew WHITE , Jie XU , Haiming ZHANG , Stephan BACHMANN , Thomas Michael BASS , Raphael BIGLER , Johannes Adrian BURKHARD , Kyle Bradley Pascual CLAGG , Francis GOSSELIN , Chong HAN , Dainis KALDRE , Sean M. KELLY , Sebastian HEROLD , Christian LEITNER
IPC: C07D401/04 , B01J23/44 , B01J23/755
CPC classification number: C07D401/04 , B01J23/44 , B01J23/755
Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.
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![PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO) PROP AN AMIDE](/abs-image/US/2019/09/26/US20190292201A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190292201A1
公开(公告)日：2019-09-26
申请号：US16441765
申请日：2019-06-14
Applicant: Genentech, Inc.
Inventor： Francis GOSSELIN , Chong HAN , Theresa CRAVILLION , Sean M. KELLY , Scott SAVAGE
IPC: C07D498/04
Abstract: Methods of making benzoxazepin oxazolidinone compounds as well as synthetic intermediates are described, including compound 18, having the structure:
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公开(公告)号：US20160200723A1
公开(公告)日：2016-07-14
申请号：US14913635
申请日：2014-08-21
Applicant: GENENTECH, INC. , ARRAY BIOPHARMA INC.
Inventor： Chong HAN , Keena GREEN , Francis GOSSELIN , Michelangelo SCALONE , Paul J. NICHOLS , Weidong LIU , Keith L. SPENCER , Zackary D. CRANE , Peter J. STENGEL , Sagar SHAKYA
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: The invention provides processes of preparation thereof useful in the preparation of compounds that can be used as CHK1 inhibitors.
Abstract translation: 本发明提供了可用于制备可用作CHK1抑制剂的化合物的制备方法。
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公开(公告)号：US20250059155A1
公开(公告)日：2025-02-20
申请号：US18776585
申请日：2024-07-18
Applicant: Genentech, Inc. , Hoffmann-La Roche Inc.
Inventor： Rene LEBL , Ngiap Kie LIM , Roland Christoph MEIER , Ugo Jonathan ORCEL , Joerg SEDELMEIER , Jeff SHEN , Lauren Elizabeth SIROIS , Jacob C. TIMMERMAN , Etienne TRACHSEL , Nicholas Andrew WHITE , Jie XU , Haiming ZHANG , Stephan BACHMANN , Thomas Michael BASS , Raphael BIGLER , Johannes Adrian BURKHARD , Kyle Bradley Pascual CLAGG , Francis GOSSELIN , Chong HAN , Dainis KALDRE , Sean M. KELLY , Sebastian HEROLD , Christian LEITNER
IPC: C07D401/04 , B01J23/44 , B01J23/755
Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.
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