公开(公告)号：US20250059155A1

公开(公告)日：2025-02-20

申请号：US18776585

申请日：2024-07-18

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc.

Inventor： Rene LEBL ,  Ngiap Kie LIM ,  Roland Christoph MEIER ,  Ugo Jonathan ORCEL ,  Joerg SEDELMEIER ,  Jeff SHEN ,  Lauren Elizabeth SIROIS ,  Jacob C. TIMMERMAN ,  Etienne TRACHSEL ,  Nicholas Andrew WHITE ,  Jie XU ,  Haiming ZHANG ,  Stephan BACHMANN ,  Thomas Michael BASS ,  Raphael BIGLER ,  Johannes Adrian BURKHARD ,  Kyle Bradley Pascual CLAGG ,  Francis GOSSELIN ,  Chong HAN ,  Dainis KALDRE ,  Sean M. KELLY ,  Sebastian HEROLD ,  Christian LEITNER

IPC: C07D401/04 ,  B01J23/44 ,  B01J23/755

Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

公开(公告)号：US20240034739A1

公开(公告)日：2024-02-01

申请号：US18479596

申请日：2023-10-02

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc.

Inventor： Allen Yu HONG ,  Nicholas WONG ,  Sean M. KELLY ,  Lauren Elizabeth SIROIS ,  Sara SCHWEGLER ,  Xin LINGHU ,  Francis GOSSELIN ,  Katarzyna Aleksandra PIECHOWICZ ,  Carmela MOLINARO ,  Dennis WETZL

IPC: C07D487/04 ,  C12P7/62 ,  C07D207/273

CPC classification number: C07D487/04 ,  C12P7/62 ,  C07D207/273

Abstract: Processes are provided herein for the preparation of a bicyclic ketone compound of formula (I), or a stereoisomer thereof:






or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and n are as defined herein; and compounds prepared by these processes.

公开(公告)号：US20230250074A1

公开(公告)日：2023-08-10

申请号：US18164302

申请日：2023-02-03

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc.

Inventor： Rene LEBL ,  Ngiap Kie LIM ,  Roland Christoph MEIER ,  Ugo Jonathan ORCEL ,  Joerg SEDELMEIER ,  Jeff SHEN ,  Lauren Elizabeth SIROIS ,  Jacob C. TIMMERMAN ,  Etienne TRACHSEL ,  Nicholas Andrew WHITE ,  Jie XU ,  Haiming ZHANG ,  Stephan BACHMANN ,  Thomas Michael BASS ,  Raphael BIGLER ,  Johannes Adrian BURKHARD ,  Kyle Bradley Pascual CLAGG ,  Francis GOSSELIN ,  Chong HAN ,  Dainis KALDRE ,  Sean M. KELLY ,  Sebastian HEROLD ,  Christian LEITNER

IPC: C07D401/04 ,  B01J23/44 ,  B01J23/755

CPC classification number: C07D401/04 ,  B01J23/44 ,  B01J23/755

Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

公开(公告)号：US20190292201A1

公开(公告)日：2019-09-26

申请号：US16441765

申请日：2019-06-14

Applicant: Genentech, Inc.

Inventor： Francis GOSSELIN ,  Chong HAN ,  Theresa CRAVILLION ,  Sean M. KELLY ,  Scott SAVAGE

IPC: C07D498/04

Abstract: Methods of making benzoxazepin oxazolidinone compounds as well as synthetic intermediates are described, including compound 18, having the structure: