公开(公告)号：US20230133667A1

公开(公告)日：2023-05-04

申请号：US18047624

申请日：2022-10-18

Applicant: RQx Pharmaceuticals, Inc. ,  Genentech, Inc.

Inventor： Peter Andrew Smith ,  Tucker Curran Roberts ,  Robert I. Higuchi ,  Prasuna Paraselli ,  Michael F. T. Koehler ,  Jacob Bradley Schwarz ,  James John Crawford ,  Cuong Q. Ly ,  Emily J. Hanan ,  Huiyong Hu ,  Yongsheng Chen ,  Zhiyong Yu ,  Paul Colin Michael Winship ,  Calum MacCleod ,  Toby Blench

IPC: C07K5/11 ,  A61P31/04 ,  A61K9/00 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K45/06 ,  C07K5/083 ,  C07K5/097 ,  C07K5/107 ,  C07K7/06

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20230057166A1

公开(公告)日：2023-02-23

申请号：US17275606

申请日：2019-09-12

Applicant: Genentech, Inc.

Inventor： Marie-Gabrielle Braun ,  Cuong Q. Ly ,  Georgette Castanedo ,  Paul Gibbons ,  Wendy Lee ,  Joachim Rudolph ,  Nicole Alice Blaquiere ,  Jacob Bradley Schwarz ,  Ramsay Beveridge ,  Jean-Philippe Leclerc ,  Alexandre Lemire ,  Leo Fu

IPC: C07D401/14 ,  C07D401/04 ,  C07D413/14 ,  C07D471/04 ,  C07D471/08 ,  A61K45/06

Abstract: Described herein are phenoxy-pyridyl-pyrimidine compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I structure or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：US12071425B2

公开(公告)日：2024-08-27

申请号：US17275606

申请日：2019-09-12

Applicant: Genentech, Inc.

Inventor： Marie-Gabrielle Braun ,  Cuong Q. Ly ,  Georgette Castanedo ,  Paul Gibbons ,  Wendy Lee ,  Joachim Rudolph ,  Nicole Alice Blaquiere ,  Jacob Bradley Schwarz ,  Ramsay Beveridge ,  Jean-Philippe Leclerc ,  Alexandre Lemire ,  Leo Fu

IPC: C07D401/14 ,  A61K45/06 ,  C07D401/04 ,  C07D413/14 ,  C07D471/04 ,  C07D471/08

CPC classification number: C07D401/14 ,  A61K45/06 ,  C07D401/04 ,  C07D413/14 ,  C07D471/04 ,  C07D471/08

Abstract: Described herein are phenoxy-pyridyl-pyrimidine compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I structure or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：US20230133817A1

公开(公告)日：2023-05-04

申请号：US18063173

申请日：2022-12-08

Applicant: RQX Pharmaceuticals, Inc. ,  Genentech, Inc.

Inventor： Yongsheng Chen ,  Peter Andrew Smith ,  Tuker Curran Roberts ,  Robert I. Higuchi ,  Prasuna Paraselli ,  Michael F.T Koehler ,  Jacob Bradley Schwarz ,  James John Crawford ,  Cuong Q. Ly ,  Emily J. Hanan ,  Huiyong Hu ,  Zhiyong Yu

IPC: C07D245/04 ,  C07K5/02 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K45/06 ,  A61K31/496 ,  A61K31/546 ,  C07K5/087 ,  C07K5/103 ,  C07K5/11 ,  C07K7/06 ,  C07K7/08 ,  C07K5/113 ,  C07K9/00 ,  C07K5/117 ,  A61K31/395 ,  A61K31/431 ,  A61K31/407 ,  A61K31/43 ,  A61K31/4196 ,  A61K31/545 ,  C07K5/09 ,  A61P31/04 ,  A61K9/00

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US11072635B2

公开(公告)日：2021-07-27

申请号：US15777509

申请日：2016-11-21

Applicant: RQX PHARMACEUTICALS, INC. ,  GENENTECH, INC.

Inventor： Yongsheng Chen ,  Peter Andrew Smith ,  Tucker Curran Roberts ,  Robert I. Higuchi ,  Prasuna Paraselli ,  Michael F. T. Koehler ,  Jacob Bradley Schwarz ,  James John Crawford ,  Cuong Q. Ly ,  Huiyong Hu ,  Zhiyong Yu

IPC: C07K7/06 ,  A61P31/04 ,  A61K9/00 ,  A61K45/06

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.