公开(公告)号：US20240369575A1

公开(公告)日：2024-11-07

申请号：US18587851

申请日：2024-02-26

Applicant: Genentech, Inc.

Inventor： Marissa Lynn MATSUMOTO ,  Domagoj VUCIC ,  Tatiana GONCHAROV

IPC: G01N33/68 ,  C07K16/40 ,  G01N33/53

Abstract: Multispecific antibodies comprising a first half antibody comprising a first antigen binding site that binds to a polyubiquitin; and a second half antibody comprising a second antigen binding site that binds a pro-inflammatory protein, such as receptor-interacting protein kinase 1 (RIP1) or receptor-interacting protein kinase 2 (RIP2), as well as methods for using the antibodies, are provided.

公开(公告)号：US20130143824A1

公开(公告)日：2013-06-06

申请号：US13654307

申请日：2012-10-17

Applicant: Genentech, Inc.

Inventor： Kurt Deshayes ,  Wayne J. FAIRBROTHER ,  John A. FLYGARE ,  Matthew C. FRANKLIN ,  Saloumeh FISCHER ,  Domagoj VUCIC

IPC: A61K38/08

CPC classification number: A61K38/08 ,  A61K38/00 ,  C07K7/08 ,  C07K14/001 ,  C07K14/4747 ,  C07K2319/00

Abstract: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.

Abstract translation: 本发明涉及用于增强哺乳动物细胞凋亡的物质组合物，以及使用这些物质组合物的方法。