公开(公告)号：US09688758B2

公开(公告)日：2017-06-27

申请号：US14455189

申请日：2014-08-08

Applicant: Genentech, Inc.

Inventor： Bernd Wranik ,  Dan L. Eaton ,  Erin H. Christensen ,  Jiansheng Wu

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C07K16/18 ,  C07K16/22 ,  C07K16/24 ,  C07K16/26

CPC classification number: C07K16/28 ,  C07K16/00 ,  C07K16/18 ,  C07K16/22 ,  C07K16/24 ,  C07K16/26 ,  C07K2317/31 ,  C07K2317/515 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2317/64

Abstract: The invention provides engineered heteromultimeric protein complexes constructed using one, two, or three tethers and methods for making, using, and purifying such complexes, such as antibodies with different binding properties.