公开(公告)号：US20220135528A1

公开(公告)日：2022-05-05

申请号：US17644861

申请日：2021-12-17

Applicant: Genentech, Inc.

Inventor： Michael F.T. Koehler ,  Peter Andrew Smith ,  Dana Winter ,  Boubacar Sow ,  Claudio Sturino ,  Guillaume Pelletier ,  Jonathan Boudreault

IPC: C07D239/42 ,  A61K31/497 ,  A61K38/12 ,  A61K38/14 ,  C07D239/28 ,  A61K31/4709 ,  A61K31/505 ,  A61K31/351 ,  A61P31/04 ,  A61K31/702 ,  A61K31/5377 ,  A61K31/545 ,  A61K31/165 ,  A61K45/06

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidases SpsB and/or LepB, an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20200377463A1

公开(公告)日：2020-12-03

申请号：US16884679

申请日：2020-05-27

Applicant: Genentech, Inc.

Inventor： Michael F.T. Koehler ,  Peter Andrew Smith ,  Dana Winter ,  Boubacar Sow ,  Claudio Sturino ,  Guillaume Pelletier ,  Jonathan Boudreault

IPC: C07D239/42 ,  A61K45/06 ,  A61K31/505 ,  A61P31/04 ,  A61K31/702 ,  A61K31/4709 ,  A61K31/545 ,  A61K38/14 ,  A61K31/497 ,  A61K31/165 ,  A61K31/351 ,  A61K38/12 ,  A61K31/5377 ,  C07D239/28

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidases SpsB and/or LepB, an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.