公开(公告)号：US20180238878A1

公开(公告)日：2018-08-23

申请号：US15849805

申请日：2017-12-21

Applicant: Genentech, Inc.

Inventor： Felix Chu ,  Oded Foreman ,  James Ziai

IPC: G01N33/569 ,  G01N33/58 ,  G01N33/574 ,  C07K16/28 ,  C12Q1/06 ,  A61K38/17

CPC classification number: G01N33/56972 ,  A61K38/177 ,  C07K16/2875 ,  C07K2317/24 ,  C07K2317/75 ,  C12Q1/06 ,  G01N33/57419 ,  G01N33/582 ,  G01N2333/70514 ,  G01N2800/52 ,  G01N2800/7028

Abstract: The present disclosure provides methods for measuring the number of CD4+ OX40+ Foxp3+ lymphocytes in a sample containing cancer cells and lymphocytes obtained from a subject by labeling lymphocytes that show CD4 expression in the sample, then labeling lymphocytes that show OX40 expression in the sample, then labeling lymphocytes that show Foxp3 expression in the sample, then measuring the number of CD4+ OX40+ Foxp3+ lymphocytes in the sample. Further provided are methods for determining the prognosis of a subject, predicting responsiveness of a subject having cancer to an OX40 agonist treatment, and methods for treating or delaying progression of cancer based on the number of CD4+ OX40+ Foxp3+ lymphocytes in a sample.

公开(公告)号：US20170339928A1

公开(公告)日：2017-11-30

申请号：US15591669

申请日：2017-05-10

Applicant: Genentech, Inc.

Inventor： Deanna Grant Wilson ,  Oded Foreman ,  Andrew Peterson ,  Xiaohui Wen ,  Suzanna J. Scales

IPC: A01K67/027 ,  A61K49/00 ,  C12N15/85 ,  C07K16/00

Abstract: A non-human transgenic animal expressing ApoL1 is provided as well as a method for generating the same. Also provided is a method for identifying an agent capable of reducing the progression of an ApoL1 mediated nephropathy. Furthermore, an isolated antibody is provided which binds to the human variants of ApoL1.