公开(公告)号：US20230052312A1

公开(公告)日：2023-02-16

申请号：US17673648

申请日：2022-02-16

Applicant: Genentech, Inc.

Inventor： Doris KIM ,  Terence Wong ,  Anan Chuntharapai ,  Cherie Louise Green

IPC: G01N33/68 ,  G01N21/64 ,  G01N15/14 ,  G01N33/574 ,  C07K16/28

Abstract: The present application relates to anti-PD-L1 antibodies and their use to detect PD-L1 in a sample from a subject. In some embodiments, the subject has been treated with a therapeutic anti-PD-L1 antibody and an anti-PD-L1 described herein does not compete for binding to PD-L1 with the therapeutic anti-PD-L1 antibody. In some embodiments, the anti-PD-L1 antibody is linked to a detectable moiety, such as a fluorophore and the anti-PD-L1 antibody is used to detect PD-L1 in a subject using flow cytometry.

公开(公告)号：US20160002355A1

公开(公告)日：2016-01-07

申请号：US14860344

申请日：2015-09-21

Applicant: Genentech, Inc.

Inventor： Jo-Anne Hongo ,  Yanhong Li ,  Luna Liu ,  John Lowe ,  Mauricio Maia ,  Rajesh Vij ,  Terence Wong ,  Keyang Xu

IPC: C07K16/42 ,  G01N33/68

CPC classification number: C07K16/4216 ,  C07K16/088 ,  C07K2317/56 ,  C07K2317/92 ,  G01N33/56994 ,  G01N33/686 ,  G01N2333/045 ,  G01N2469/20

Abstract: The invention provides anti-idiotypic HCMV antibodies as well as methods of using the same.

公开(公告)号：US20140115729A1

公开(公告)日：2014-04-24

申请号：US14137927

申请日：2013-12-20

Applicant: Genentech, Inc.

Inventor： Lawren Wu ,  Mercedesz Balazs ,  Hans Brightbill ,  Andrew Chan ,  Yvonne Chen ,  Anan Chuntharapai ,  Mark Dennis ,  Terence Wong

IPC: C07K16/42

CPC classification number: C07K16/4291 ,  A01K67/0278 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/0387 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/73

Abstract: The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.

Abstract translation: 本申请涉及凋亡性抗IgE抗体，编码它的核酸，其治疗组合物及其在治疗IgE介导的病症中的用途。

公开(公告)号：US11292843B2

公开(公告)日：2022-04-05

申请号：US16885067

申请日：2020-05-27

Applicant: Genentech, Inc.

Inventor： Doris Kim ,  Terence Wong ,  Anan Chuntharapai ,  Cherie Louise Green

IPC: C07K16/28 ,  G01N33/574

Abstract: The present application relates to anti-PD-L1 antibodies and their use to detect PD-L1 in a sample from a subject. In some embodiments, the subject has been treated with a therapeutic anti-PD-L1 antibody and an anti-PD-L1 described herein does not compete for binding to PD-L1 with the therapeutic anti-PD-L1 antibody. In some embodiments, the anti-PD-L1 antibody is linked to a N detectable moiety, such as a fluorophore and the anti-PD-L1 antibody is used to detect PD-L1 in a subject using flow cytometry.

公开(公告)号：US20130266973A1

公开(公告)日：2013-10-10

申请号：US13841691

申请日：2013-03-15

Applicant: GENENTECH, INC.

Inventor： Jo-Anne Hongo ,  Yanhong Li ,  Luna Liu ,  John Lowe ,  Mauricio Maia ,  Rajesh Vij ,  Terence Wong ,  Keyang XU

IPC: C07K16/42

CPC classification number: C07K16/4216 ,  C07K16/088 ,  C07K2317/56 ,  C07K2317/92 ,  G01N33/56994 ,  G01N33/686 ,  G01N2333/045 ,  G01N2469/20

Abstract: The invention provides anti-idiotypic HCMV antibodies as well as methods of using the same.

Abstract translation: 本发明提供抗独特型HCMV抗体及其使用方法。