公开(公告)号：US20200291119A1

公开(公告)日：2020-09-17

申请号：US16885067

申请日：2020-05-27

Applicant: Genentech, Inc.

Inventor： Doris KIM ,  Terence WONG ,  Anan CHUNTHARAPAI ,  Cherie Louise GREEN

IPC: C07K16/28 ,  G01N33/574

Abstract: The present application relates to anti-PD-L1 antibodies and their use to detect PD-L1 in a sample from a subject. In some embodiments, the subject has been treated with a therapeutic anti-PD-L1 antibody and an anti-PD-L1 described herein does not compete for binding to PD-L1 with the therapeutic anti-PD-L1 antibody. In some embodiments, the anti-PD-L1 antibody is linked to a N detectable moiety, such as a fluorophore and the anti-PD-L1 antibody is used to detect PD-L1 in a subject using flow cytometry.

公开(公告)号：US20230052312A1

公开(公告)日：2023-02-16

申请号：US17673648

申请日：2022-02-16

Applicant: Genentech, Inc.

Inventor： Doris KIM ,  Terence Wong ,  Anan Chuntharapai ,  Cherie Louise Green

IPC: G01N33/68 ,  G01N21/64 ,  G01N15/14 ,  G01N33/574 ,  C07K16/28

Abstract: The present application relates to anti-PD-L1 antibodies and their use to detect PD-L1 in a sample from a subject. In some embodiments, the subject has been treated with a therapeutic anti-PD-L1 antibody and an anti-PD-L1 described herein does not compete for binding to PD-L1 with the therapeutic anti-PD-L1 antibody. In some embodiments, the anti-PD-L1 antibody is linked to a detectable moiety, such as a fluorophore and the anti-PD-L1 antibody is used to detect PD-L1 in a subject using flow cytometry.

公开(公告)号：US20220267864A1

公开(公告)日：2022-08-25

申请号：US17743230

申请日：2022-05-12

Applicant: Genentech, Inc.

Inventor： YounJeong CHOI ,  Omar KABBARAH ,  Doris KIM

IPC: C12Q1/6886 ,  A61K31/517 ,  A61K39/395 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574

Abstract: The invention provides methods and compositions to detect expression of one or more biomarkers, including FGFR3, TP53, and/or EGFR, for treating, diagnosing, and providing a prognosis for cancer, e.g., bladder cancer. The invention also provides kits and articles of manufacture for use in the methods.

公开(公告)号：US20170306418A1

公开(公告)日：2017-10-26

申请号：US15628775

申请日：2017-06-21

Applicant: Genentech, Inc.

Inventor： YounJeong CHOI ,  Omar KABBARAH ,  Doris KIM

IPC: C12Q1/68 ,  A61K45/06 ,  A61K31/517 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574 ,  A61K39/395 ,  C07K16/18

CPC classification number: C12Q1/6886 ,  A61K31/517 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/3038 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N2333/4748 ,  G01N2333/71 ,  G01N2800/52

Abstract: The invention provides methods and compositions to detect expression of one or more biornarkers, including FGFR3, TP53, and/or EGFR, for treating, diagnosing, and providing a prognosis for cancer, e.g., bladder cancer. The invention also provides kits and articles of manufacture for use in the methods.