公开(公告)号：US20210230243A1

公开(公告)日：2021-07-29

申请号：US17067508

申请日：2020-10-09

Applicant: Genentech, Inc. ,  Xencor, Inc.

Inventor： John Desjarlais ,  Matthew Bernett ,  Michael Hedvat ,  Rajat Varma ,  Suzanne Schubbert ,  Christine Bonzon ,  Rumana Rashid ,  Juan Diaz ,  Patrick Holder ,  Christine Huang

IPC: C07K14/54 ,  C07K16/28 ,  A61P35/00

Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.

公开(公告)号：US20240294593A1

公开(公告)日：2024-09-05

申请号：US18416464

申请日：2024-01-18

Applicant: Genentech, Inc. ,  Xencor, Inc.

Inventor： John Desjarlais ,  Matthew Bernett ,  Michael Hedvat ,  Rajat Varma ,  Suzanne Schubbert ,  Christine Bonzon ,  Rumana Rashid ,  Juan Diaz ,  Patrick Holder ,  Christine Huang

IPC: C07K14/54 ,  A61K38/00 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K14/5443 ,  A61P35/00 ,  C07K16/2818 ,  A61K38/00 ,  C07K2319/30

Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.

公开(公告)号：US11932675B2

公开(公告)日：2024-03-19

申请号：US17067508

申请日：2020-10-09

Applicant: Genentech, Inc. ,  Xencor, Inc.

Inventor： John Desjarlais ,  Matthew Bernett ,  Michael Hedvat ,  Rajat Varma ,  Suzanne Schubbert ,  Christine Bonzon ,  Rumana Rashid ,  Juan Diaz ,  Patrick Holder ,  Christine Huang

IPC: C07K14/00 ,  A61P35/00 ,  C07K14/54 ,  C07K16/28 ,  A61K38/00

CPC classification number: C07K14/5443 ,  A61P35/00 ,  C07K16/2818 ,  A61K38/00 ,  C07K2319/30

Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.