-
公开(公告)号：US20210230243A1
公开(公告)日：2021-07-29
申请号：US17067508
申请日：2020-10-09
Applicant: Genentech, Inc. , Xencor, Inc.
Inventor： John Desjarlais , Matthew Bernett , Michael Hedvat , Rajat Varma , Suzanne Schubbert , Christine Bonzon , Rumana Rashid , Juan Diaz , Patrick Holder , Christine Huang
Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.
-
公开(公告)号：US11932675B2
公开(公告)日：2024-03-19
申请号：US17067508
申请日：2020-10-09
Applicant: Genentech, Inc. , Xencor, Inc.
Inventor： John Desjarlais , Matthew Bernett , Michael Hedvat , Rajat Varma , Suzanne Schubbert , Christine Bonzon , Rumana Rashid , Juan Diaz , Patrick Holder , Christine Huang
CPC classification number: C07K14/5443 , A61P35/00 , C07K16/2818 , A61K38/00 , C07K2319/30
Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.
-
公开(公告)号：US20240294593A1
公开(公告)日：2024-09-05
申请号：US18416464
申请日：2024-01-18
Applicant: Genentech, Inc. , Xencor, Inc.
Inventor： John Desjarlais , Matthew Bernett , Michael Hedvat , Rajat Varma , Suzanne Schubbert , Christine Bonzon , Rumana Rashid , Juan Diaz , Patrick Holder , Christine Huang
CPC classification number: C07K14/5443 , A61P35/00 , C07K16/2818 , A61K38/00 , C07K2319/30
Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.
-
4.发明申请公开(公告)号：US20190016778A1
公开(公告)日：2019-01-17
申请号：US16025963
申请日：2018-07-02
Applicant: Xencor, Inc.
Inventor： Matthew J. Bernett , John Desjarlais , Rajat Varma , Suzanne Schubbert , Juan Diaz
IPC: C07K14/735 , C12N15/63 , A61P35/00 , C07K14/54
Abstract: The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc fusion protein and an antigen binding domain Fc fusion proteins. In some instances, the antigen binding domain binds to CD8, NKG2A, or NKG2D.
-
5.发明公开公开(公告)号：US20240025968A1
公开(公告)日：2024-01-25
申请号：US18296591
申请日：2023-04-06
Applicant: Xencor, Inc.
Inventor： Matthew J. Bernett , John R. Desjarlais , Suzanne Schubbert
IPC: C07K14/715 , C07K14/54 , C12N15/63 , C07K16/28
CPC classification number: C07K14/7155 , C07K14/5443 , C07K2319/30 , C07K16/2896 , C12N15/63
Abstract: The present invention is directed to novel targeted heterodimeric fusion proteins comprising an IL-15/IL-15Rα Fc-fusion protein and a LAG-3 antibody fragment-Fc fusion protein.
-
Patent Agency Ranking
6.发明申请公开(公告)号：US20220073588A1
公开(公告)日：2022-03-10
申请号：US17366565
申请日：2021-07-02
Applicant: Xencor, Inc.
Inventor： Matthew J. Bernett , John Desjarlais , Rajat Varma , Suzanne Schubbert , Juan Diaz
IPC: C07K14/735 , C07K14/54 , A61P35/00 , C07K16/28 , C07K14/715 , C12N15/62 , A61K39/395 , C12N15/63
Abstract: The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc fusion protein and an antigen binding domain Fc fusion proteins. In some instances, the antigen binding domain binds to CD8, NKG2A, or NKG2D.
-
公开(公告)号：US20220227867A1
公开(公告)日：2022-07-21
申请号：US17561613
申请日：2021-12-23
Applicant: Xencor, Inc.
Inventor： Matthew J. Bernett , John R. Desjarlais , Gregory Moore , Suzanne Schubbert
IPC: C07K16/28 , C07K14/54 , C07K14/715 , C12N15/63
Abstract: The present invention is directed to novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc-fusion protein and a ICOS antibody fragment-Fc fusion protein.
-
8.发明授权公开(公告)号：US11377477B2
公开(公告)日：2022-07-05
申请号：US16600236
申请日：2019-10-11
Applicant: Xencor, Inc.
Inventor： Matthew Bernett , John R. Desjarlais , Michael Hedvat , Suzanne Schubbert , Christine Bonzon , Rumana Rashid , Rajat Varma
Abstract: The present invention is directed to novel PD-1 targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc-fusion protein and a PD-1 antibody fragment-Fc fusion protein. In some embodiments, the PD-1 targeted IL-15/Rα-Fc fusion proteins are administered to a patient to treat cancer. In some embodiments, the PD-1 targeted IL-15/Rα-Fc fusion proteins are administered in combination with a PD-1 blockade antibody such as nivolumab and/or pembrolizumab. In some embodiments, the PD-1 targeted IL-15/Rα-Fc fusion proteins do not compete with a PD-1 blockade antibody such as nivolumab and/or pembrolizumab for antigen binding.
-
公开(公告)号：US20220144956A1
公开(公告)日：2022-05-12
申请号：US17520590
申请日：2021-11-05
Applicant: Xencor, Inc.
Inventor： John R. Desjarlais , Gregory Moore , Suzanne Schubbert , Alex Nisthal
Abstract: Provided herein are novel antibodies that bind TGFßRII and methods of making and using such antibodies. The antibodies provided advantageously block TGFß activity in a broad population of cells (e.g., active and unactivated hematopoietic cells), and find use wherein such blockage of TGFß activity is desirable, for example, for the treatment of cancers. In some embodiments, the antibodies are novel αTGFßRII×αCD5 and αTGFßRII×αPD-1 bispecific antibodies.
-
10.发明授权公开(公告)号：US12139525B2
公开(公告)日：2024-11-12
申请号：US17366565
申请日：2021-07-02
Applicant: Xencor, Inc.
Inventor： Matthew J. Bernett , John Desjarlais , Rajat Varma , Suzanne Schubbert , Juan Diaz
IPC: C07K14/00 , A61K39/395 , A61P35/00 , C07K14/54 , C07K14/715 , C07K14/735 , C07K16/28 , C12N15/62 , C12N15/63 , A61K38/17 , A61K38/20 , A61K39/00
Abstract: The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc fusion protein and an antigen binding domain Fc fusion proteins. In some instances, the antigen binding domain binds to CD8, NKG2A, or NKG2D.
-
-
-
-
-
-
-
-
-
Search Results
13
records
(took 0.032 seconds)
