公开(公告)号：US11932675B2

公开(公告)日：2024-03-19

申请号：US17067508

申请日：2020-10-09

Applicant: Genentech, Inc. ,  Xencor, Inc.

Inventor： John Desjarlais ,  Matthew Bernett ,  Michael Hedvat ,  Rajat Varma ,  Suzanne Schubbert ,  Christine Bonzon ,  Rumana Rashid ,  Juan Diaz ,  Patrick Holder ,  Christine Huang

IPC: C07K14/00 ,  A61P35/00 ,  C07K14/54 ,  C07K16/28 ,  A61K38/00

CPC classification number: C07K14/5443 ,  A61P35/00 ,  C07K16/2818 ,  A61K38/00 ,  C07K2319/30

Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.

公开(公告)号：US20210230243A1

公开(公告)日：2021-07-29

申请号：US17067508

申请日：2020-10-09

Applicant: Genentech, Inc. ,  Xencor, Inc.

Inventor： John Desjarlais ,  Matthew Bernett ,  Michael Hedvat ,  Rajat Varma ,  Suzanne Schubbert ,  Christine Bonzon ,  Rumana Rashid ,  Juan Diaz ,  Patrick Holder ,  Christine Huang

IPC: C07K14/54 ,  C07K16/28 ,  A61P35/00

Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.

公开(公告)号：US20240294593A1

公开(公告)日：2024-09-05

申请号：US18416464

申请日：2024-01-18

Applicant: Genentech, Inc. ,  Xencor, Inc.

Inventor： John Desjarlais ,  Matthew Bernett ,  Michael Hedvat ,  Rajat Varma ,  Suzanne Schubbert ,  Christine Bonzon ,  Rumana Rashid ,  Juan Diaz ,  Patrick Holder ,  Christine Huang

IPC: C07K14/54 ,  A61K38/00 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K14/5443 ,  A61P35/00 ,  C07K16/2818 ,  A61K38/00 ,  C07K2319/30

Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.

公开(公告)号：US11851466B2

公开(公告)日：2023-12-26

申请号：US17062458

申请日：2020-10-02

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  John R. Desjarlais ,  Rajat Varma ,  Ke Liu ,  Rumana Rashid ,  Nargess Hassanzadeh-Kiabi ,  Michael Hedvat

IPC: C07K16/46 ,  C07K14/54 ,  A61P35/00 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K14/5434 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2319/30

Abstract: The present invention relates to targeted IL-12 heterodimeric Fc fusion proteins, where the fusion proteins bind to human PD-1 or human PD-L1.

公开(公告)号：US20230220081A1

公开(公告)日：2023-07-13

申请号：US18065462

申请日：2022-12-13

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  Rumana Rashid ,  John Desjarlais ,  Rajat Varma ,  Christine Bonzon

IPC: C07K16/28 ,  C07K14/54 ,  C07K14/715 ,  C12N15/63 ,  A61P35/00 ,  A61K39/00 ,  A61K38/00

CPC classification number: C07K16/2818 ,  C07K14/5443 ,  C07K14/7155 ,  C12N15/63 ,  A61P35/00 ,  C07K2317/24 ,  C07K2317/524 ,  A61K2039/505 ,  C07K2317/94 ,  C07K2319/30 ,  C07K2317/73 ,  C07K2317/526 ,  C07K2317/35 ,  C07K2317/92 ,  C07K2317/31 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/74 ,  A61K38/00 ,  C07K2319/32

Abstract: The present invention is directed to novel bispecific heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc-fusion protein and a PD-1 antibody fragment-Fc fusion protein.

公开(公告)号：US11377477B2

公开(公告)日：2022-07-05

申请号：US16600236

申请日：2019-10-11

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  John R. Desjarlais ,  Michael Hedvat ,  Suzanne Schubbert ,  Christine Bonzon ,  Rumana Rashid ,  Rajat Varma

IPC: C07K16/28 ,  A61K39/395 ,  C07K14/28 ,  C12N15/63 ,  C07K14/54 ,  A61K38/00

Abstract: The present invention is directed to novel PD-1 targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc-fusion protein and a PD-1 antibody fragment-Fc fusion protein. In some embodiments, the PD-1 targeted IL-15/Rα-Fc fusion proteins are administered to a patient to treat cancer. In some embodiments, the PD-1 targeted IL-15/Rα-Fc fusion proteins are administered in combination with a PD-1 blockade antibody such as nivolumab and/or pembrolizumab. In some embodiments, the PD-1 targeted IL-15/Rα-Fc fusion proteins do not compete with a PD-1 blockade antibody such as nivolumab and/or pembrolizumab for antigen binding.

公开(公告)号：US11358999B2

公开(公告)日：2022-06-14

申请号：US16592656

申请日：2019-10-03

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  John R. Desjarlais ,  Rajat Varma ,  Ke Liu ,  Nargess Hassanzadeh-Kiabi ,  Rumana Rashid

IPC: C07K14/54 ,  C07K19/00 ,  C07K1/18 ,  A61K38/20 ,  A61K38/00

Abstract: The present invention provides novel IL-12 Fc fusion proteins, methods of making and using the same. The IL-12. Fc fusion proteins are useful for treatment of cancer and can be used in combination with checkpoint blockade.

公开(公告)号：US11319355B2

公开(公告)日：2022-05-03

申请号：US16206849

申请日：2018-11-30

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  John Desjarlais ,  Rajat Varma ,  Rumana Rashid

IPC: C07K14/55 ,  C07K14/735 ,  C12N15/85 ,  A61K38/00

Abstract: The present invention provides IL-2-Fc fusion proteins comprising IL-2 variants.

公开(公告)号：US20230027540A1

公开(公告)日：2023-01-26

申请号：US17886103

申请日：2022-08-11

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  John R. Desjarlais ,  Rajat Varma ,  Ke Liu ,  Nargess Hassanzadeh-Kiabi ,  Rumana Rashid

IPC: C07K14/54 ,  C07K19/00

Abstract: The present invention provides novel IL-12 Fc fusion proteins, methods of making and using the same. The IL-12 Fc fusion proteins are useful for treatment of cancer and can be used in combination with checkpoint blockade.

公开(公告)号：US11505595B2

公开(公告)日：2022-11-22

申请号：US16388729

申请日：2019-04-18

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  John Desjarlais ,  Rumana Rashid ,  Rajat Varma ,  Christine Bonzon

IPC: C07K14/715 ,  C07K14/54 ,  C07K16/28 ,  C07K19/00 ,  C12N15/63 ,  A61K38/00

Abstract: The present invention is directed to novel targeted heterodimeric fusion proteins comprising an IL-15/IL-15Rα Fc-fusion protein and a TIM-3 antibody fragment-Fc fusion protein.