公开(公告)号：US20140147387A1

公开(公告)日：2014-05-29

申请号：US13872539

申请日：2013-04-29

Applicant: General Electric Company

Inventor： Matthew David Butts ,  Robert Edgar Colborn ,  Peter John Bonitatibus, JR. ,  Andrew Soliz Torres ,  Brian Christopher Bales ,  Michael Ernest Marino ,  Bruce Allan Hay ,  Amit Mohan Kulkarni

IPC: A61K49/00

CPC classification number: A61K49/101 ,  A61K49/0002 ,  A61K49/04 ,  A61K49/0428 ,  A61K49/0485 ,  A61K49/1818 ,  A61K49/1848 ,  B82Y5/00 ,  B82Y30/00 ,  C01G35/00 ,  Y10S977/773 ,  Y10S977/779 ,  Y10S977/927 ,  Y10S977/928 ,  Y10T428/2982

Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.

Abstract translation: 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包含用硅烷官能化的非靶向两性离子部分共价官能化的纳米颗粒过渡金属氧化物。

公开(公告)号：US09399075B2

公开(公告)日：2016-07-26

申请号：US13872539

申请日：2013-04-29

Applicant: General Electric Company

Inventor： Matthew David Butts ,  Robert Edgar Colborn ,  Peter John Bonitatibus, Jr. ,  Andrew Soliz Torres ,  Brian Christopher Bales ,  Michael Ernest Marino ,  Bruce Allan Hay ,  Amit Mohan Kulkarni

IPC: A61K49/04 ,  C01G35/00 ,  A61K49/00 ,  A61K49/18 ,  B82Y5/00 ,  B82Y30/00

CPC classification number: A61K49/101 ,  A61K49/0002 ,  A61K49/04 ,  A61K49/0428 ,  A61K49/0485 ,  A61K49/1818 ,  A61K49/1848 ,  B82Y5/00 ,  B82Y30/00 ,  C01G35/00 ,  Y10S977/773 ,  Y10S977/779 ,  Y10S977/927 ,  Y10S977/928 ,  Y10T428/2982

Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.

Abstract translation: 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包含用硅烷官能化的非靶向两性离子部分共价官能化的纳米颗粒过渡金属氧化物。