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公开(公告)号：US12201836B2
公开(公告)日：2025-01-21
申请号：US17342186
申请日：2021-06-08
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Jeffrey Michael Ashe , Victoria Eugenia Cotero , Michael Ernest Marino
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of lymphatic tissue that include applying one or more energy pulses to a neuron of a subject, e.g., via an electrode positioned to deliver sufficient energy to the neuron, to modulate immune function. For example, an adaptive immune reflex of a subject may be modulated via neuromodulation.
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公开(公告)号：US20210299449A1
公开(公告)日：2021-09-30
申请号：US17342186
申请日：2021-06-08
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Jeffrey Michael Ashe , Victoria Eugenia Cotero , Michael Ernest Marino
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of lymphatic tissue that include applying one or more energy pulses to a neuron of a subject, e.g., via an electrode positioned to deliver sufficient energy to the neuron, to modulate immune function. For example, an adaptive immune reflex of a subject may be modulated via neuromodulation
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3.发明申请公开(公告)号：US20180121760A1
公开(公告)日：2018-05-03
申请号：US15796379
申请日：2017-10-27
Applicant: General Electric Company
Inventor： Alberto Santamaria-Pang , Daniel Eugene Meyer , Michael Ernest Marino , Qing Li , Dmitry V. Dylov , Aritra Chowdhury
CPC classification number: G06K9/6256 , G06K9/44 , G06K9/6267 , G06K9/6274 , G06K2209/05 , G06N3/04 , G06N3/0454 , G06N3/08 , G06N3/084 , G06T7/0012 , G06T7/11 , G06T7/155 , G06T2200/04 , G06T2207/10056 , G06T2207/10064 , G06T2207/30016 , G06T2207/30101 , G06T2207/30172 , G09B23/30 , G09B23/303 , G16H50/20 , G16H50/50
Abstract: The present approach relates to the use of trained artificial neural networks, such as convolutional neural networks, to classify vascular structures, such as using a hierarchical classification scheme. In certain approaches, the artificial neural network is trained using training data that is all or partly derived from synthetic vascular representations.
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Patent Agency Ranking
公开(公告)号：US20140147387A1
公开(公告)日：2014-05-29
申请号：US13872539
申请日：2013-04-29
Applicant: General Electric Company
Inventor： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino , Bruce Allan Hay , Amit Mohan Kulkarni
IPC: A61K49/00
CPC classification number: A61K49/101 , A61K49/0002 , A61K49/04 , A61K49/0428 , A61K49/0485 , A61K49/1818 , A61K49/1848 , B82Y5/00 , B82Y30/00 , C01G35/00 , Y10S977/773 , Y10S977/779 , Y10S977/927 , Y10S977/928 , Y10T428/2982
Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.
Abstract translation: 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包含用硅烷官能化的非靶向两性离子部分共价官能化的纳米颗粒过渡金属氧化物。
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5.发明申请公开(公告)号：US20190001002A1
公开(公告)日：2019-01-03
申请号：US16026854
申请日：2018-07-03
Inventor： Paul Francis Fitzgerald , Michael Ernest Marino , Peter Michael Edic , Daniel Eugene Meyer , Peter J. Bonitatibus, JR. , Robert Edgar Colborn , Benjamin Ming-Yueh Yeh
IPC: A61K49/04
Abstract: Design and use of an administered drug in the form of a nanoparticle or molecule is described. In certain examples, the nanoparticle has a core and a shell surrounding the core. The core may be configured or designed to provide useful X-ray attenuating properties, gamma ray emission properties, magnetic properties, or therapeutic effects. In certain aspects, the nanoparticle or molecule is sized so as to either distribute from or remain in the blood pool, while still being eliminated by the kidneys.
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公开(公告)号：US09399075B2
公开(公告)日：2016-07-26
申请号：US13872539
申请日：2013-04-29
Applicant: General Electric Company
Inventor： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino , Bruce Allan Hay , Amit Mohan Kulkarni
CPC classification number: A61K49/101 , A61K49/0002 , A61K49/04 , A61K49/0428 , A61K49/0485 , A61K49/1818 , A61K49/1848 , B82Y5/00 , B82Y30/00 , C01G35/00 , Y10S977/773 , Y10S977/779 , Y10S977/927 , Y10S977/928 , Y10T428/2982
Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.
Abstract translation: 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包含用硅烷官能化的非靶向两性离子部分共价官能化的纳米颗粒过渡金属氧化物。
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公开(公告)号：US10740651B2
公开(公告)日：2020-08-11
申请号：US15796379
申请日：2017-10-27
Applicant: General Electric Company
Inventor： Alberto Santamaria-Pang , Daniel Eugene Meyer , Michael Ernest Marino , Qing Li , Dmitry V. Dylov , Aritra Chowdhury
IPC: G06K9/00 , G06K9/62 , G06N3/08 , G06N3/04 , G09B23/30 , G06T7/00 , G16H50/20 , G06K9/44 , G06T7/11 , G06T7/155 , G16H50/50
Abstract: The present approach relates to the use of trained artificial neural networks, such as convolutional neural networks, to classify vascular structures, such as using a hierarchical classification scheme. In certain approaches, the artificial neural network is trained using training data that is all or partly derived from synthetic vascular representations.
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8.发明申请公开(公告)号：US20190001001A1
公开(公告)日：2019-01-03
申请号：US15640880
申请日：2017-07-03
Inventor： Paul Francis Fitzgerald , Michael Ernest Marino , Peter Michael Edic , Daniel Eugene Meyer , Peter J. Bonitatibus, Jr. , Robert Edgar Colborn , Benjamin Ming-Yueh Yeh
IPC: A61K49/04
Abstract: Design and use of an administered drug in the form of a nanoparticle or molecule is described. In certain examples, the nanoparticle has a core and a shell surrounding the core. The core may be configured or designed to provide useful X-ray attenuating properties, gamma ray emission properties, magnetic properties, or therapeutic effects. In certain aspects, the nanoparticle or molecule is sized so as to either distribute from or remain in the blood pool, while still being eliminated by the kidneys.
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