公开(公告)号：US20030083252A1

公开(公告)日：2003-05-01

申请号：US10029016

申请日：2001-12-20

申请人： Genetics Institute, Inc.

发明人： Anthony J. Celeste ,  John M. Wozney ,  R. Scott Thies

IPC分类号： A61K038/17

CPC分类号： A61K38/1875 ,  C07K14/51 ,  C07K14/575 ,  C07K2319/00 ,  C12N5/0619 ,  C12N2501/155 ,  Y10S930/12

摘要： Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction and/or maintenance of bone, cartilage and/or other connective tissue, and/or neuronal tissue.

公开(公告)号：US20020137133A1

公开(公告)日：2002-09-26

申请号：US09874628

申请日：2001-06-05

申请人： Genetics Institute, Inc.

发明人： John M. Wozney ,  Anthony J. Celeste ,  R. Scott Thies ,  Noboru Yamaji

IPC分类号： C07K014/705 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K14/51

摘要： Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding said proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to said BMP receptor proteins.

摘要翻译： 公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质，以及编码所述蛋白质的DNA分子和使用受体蛋白质的方法。 还公开了截短的BMP受体蛋白质和作为所述BMP受体蛋白质的配体的分子。