公开(公告)号：US20150218256A1

公开(公告)日：2015-08-06

申请号：US14429199

申请日：2013-10-01

Applicant: GENEURO SA

Inventor： Hervé Perron ,  Reza Firouzi ,  Patrick Küry ,  Raphaël Faucard ,  Alexandra Madeira ,  Julie Joanou

IPC: C07K16/10 ,  A61K39/42 ,  A61K31/225 ,  A61K31/194 ,  A61K31/221 ,  A61K31/155

CPC classification number: C07K16/1036 ,  A61K31/155 ,  A61K31/17 ,  A61K31/194 ,  A61K31/221 ,  A61K31/223 ,  A61K31/225 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  A61K2300/00 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76

Abstract: The present invention deals with innovative compounds and compositions for preventing and/or treating a newly discovered detrimental mechanism, which blocks the endogenous myelin repair capacity of the adult nervous system (NS) in diseases associated with the expression of HERV-W envelope protein (ENV), in particular of its MSRV subtype.

Abstract translation: 本发明涉及用于预防和/或治疗新发现的有害机制的创新化合物和组合物，其阻断与HERV-W包膜蛋白（ENV）表达相关的疾病中的成年神经系统（NS）的内源性髓鞘修复能力 ），特别是其MSRV亚型。

公开(公告)号：US20170101461A1

公开(公告)日：2017-04-13

申请号：US15314017

申请日：2015-05-27

Applicant: Geneuro SA

Inventor： Herve Perron ,  Francois Curtin ,  Alois Lang ,  Raphael Faucard ,  Julie Medina ,  Alexandra Madeira ,  Nadege Gehin

IPC: C07K16/10 ,  C12Q1/70 ,  A61K31/7072 ,  A61K39/42 ,  A61K45/06

CPC classification number: C07K16/1063 ,  A61K31/7072 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C12Q1/702 ,  A61K2300/00

Abstract: The invention relates to an antibody, a fragment or a derivative thereof, for use as an antiretroviral drug targeting a virus belonging to human endogenous retroviruses type W (HERV-W), wherein said antibody, fragment or derivative thereof is directed against HERV-W Envelope protein (HERV-W Env). The invention also relates to a composition comprising said antibody and a retroviral reverse-transcriptase inhibitory drug, for use as an antiretroviral drug targeting a virus belonging to HERV-W.

公开(公告)号：US10894820B2

公开(公告)日：2021-01-19

申请号：US16362193

申请日：2019-03-22

Applicant: Geneuro SA

Inventor： Herve Perron ,  Francois Curtin ,  Alois Lang ,  Raphael Faucard ,  Julie Medina ,  Alexandra Madeira ,  Nadege Gehin

IPC: C07K16/10 ,  A61K39/42 ,  A61K45/06 ,  A61K31/7072 ,  C12Q1/70 ,  A61K39/00

Abstract: The invention relates to an antibody, a fragment or a derivative thereof, for use as an antiretroviral drug targeting a virus belonging to human endogenous retroviruses type W (HERV-W), wherein said antibody, fragment or derivative thereof is directed against HERV-W Envelope protein (HERV-W Env). The invention also relates to a composition comprising said antibody and a retroviral reverse-transcriptase inhibitory drug, for use as an antiretroviral drug targeting a virus belonging to HERV-W.

公开(公告)号：US20190263895A1

公开(公告)日：2019-08-29

申请号：US16362193

申请日：2019-03-22

Applicant: Geneuro SA

Inventor： Herve Perron ,  Francois Curtin ,  Alois Lang ,  Raphael Faucard ,  Julie Medina ,  Alexandra Madeira ,  Nadege Gehin

IPC: C07K16/10 ,  A61K45/06 ,  A61K31/7072 ,  C12Q1/70 ,  A61K39/42

Abstract: The invention relates to an antibody, a fragment or a derivative thereof, for use as an antiretroviral drug targeting a virus belonging to human endogenous retroviruses type W (HERV-W), wherein said antibody, fragment or derivative thereof is directed against HERV-W Envelope protein (HERV-W Env). The invention also relates to a composition comprising said antibody and a retroviral reverse-transcriptase inhibitory drug, for use as an antiretroviral drug targeting a virus belonging to HERV-W.

公开(公告)号：US09840550B2

公开(公告)日：2017-12-12

申请号：US14429199

申请日：2013-10-01

Applicant: GENEURO SA

Inventor： Hervé Perron ,  Reza Firouzi ,  Patrick Küry ,  Raphaël Faucard ,  Alexandra Madeira ,  Julie Joanou

IPC: A61K39/42 ,  A61K31/17 ,  A61K31/194 ,  C07K16/10 ,  A61K45/06 ,  A61K31/155 ,  A61K31/223 ,  A61K31/225 ,  A61K31/221 ,  A61K39/00

CPC classification number: C07K16/1036 ,  A61K31/155 ,  A61K31/17 ,  A61K31/194 ,  A61K31/221 ,  A61K31/223 ,  A61K31/225 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  A61K2300/00 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76

Abstract: The present invention deals with innovative compounds and compositions for preventing and/or treating a newly discovered detrimental mechanism, which blocks the endogenous myelin repair capacity of the adult nervous system (NS) in diseases associated with the expression of HERV-W envelope protein (ENV), in particular of its MSRV subtype.