公开(公告)号：US11160801B2

公开(公告)日：2021-11-02

申请号：US16481172

申请日：2018-01-29

申请人： Genfit

发明人： Jean-Francois Delhomel ,  Enrico Perspicace ,  Zouher Majd ,  Peggy Parroche ,  Robert Walczak ,  Pascal Bonnet ,  Jade Fogha

IPC分类号： C07D405/14 ,  A61K31/496 ,  A61K31/192 ,  A61K31/40 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/506

摘要： The present invention provides novel compounds that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases, or cholestatic diseases.

公开(公告)号：US10987351B2

公开(公告)日：2021-04-27

申请号：US16481140

申请日：2018-01-29

申请人： Genfit

发明人： Jean-Francois Delhomel ,  Enrico Perspicace ,  Zouher Majd ,  Peggy Parroche ,  Robert Walczak ,  Pascal Bonnet ,  Jade Fogha

IPC分类号： A61K31/495 ,  A61K31/216 ,  A61K31/341 ,  A61K31/445 ,  A61K31/55 ,  C07D221/00 ,  C07D241/04 ,  C07D307/36 ,  C07D405/10

摘要： The present invention provides novel compounds of formula (Ia) that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases, or cholestatic diseases.

公开(公告)号：US20220133716A1

公开(公告)日：2022-05-05

申请号：US17494458

申请日：2021-10-05

申请人： Genfit

发明人： Jean-Francois Delhomel ,  Enrico Perspicace ,  Zouher Majd ,  Peggy Parroche ,  Robert Walczak ,  Pascal Bonnet ,  Jade Fogha

IPC分类号： A61K31/496 ,  A61K31/192 ,  C07D405/14 ,  A61K31/506 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/40

摘要： The present invention provides novel compounds that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases, or cholestatic diseases.

公开(公告)号：US20190388414A1

公开(公告)日：2019-12-26

申请号：US16481172

申请日：2018-01-29

申请人： Genfit

发明人： Jean-Francois Delhomel ,  Enrico Perspicace ,  Zouher Majd ,  Peggy Parroche ,  Robert Walczak ,  Pascal Bonnet ,  Jade Fogha

IPC分类号： A61K31/496 ,  C07D405/14 ,  A61K31/506 ,  A61K31/192 ,  A61K31/40 ,  A61K31/4184 ,  A61K31/4439

摘要： The present invention provides novel compounds that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases, or cholestatic diseases.

公开(公告)号：US11077115B2

公开(公告)日：2021-08-03

申请号：US16481200

申请日：2018-01-29

申请人： Genfit

发明人： Jean-Francois Delhomel ,  Enrico Perspicace ,  Zouher Majd ,  Peggy Parroche ,  Robert Walczak ,  Pascal Bonnet ,  Jade Fogha

IPC分类号： A61K31/5377 ,  A61K31/192 ,  A61K31/341 ,  A61K31/40 ,  A61K31/427 ,  A61K31/428 ,  A61K31/5375 ,  A61K31/54 ,  A61K31/541 ,  C07D279/12 ,  C07D295/155 ,  C07D307/52 ,  C07D413/04 ,  C07D417/04

摘要： The present invention provides novel compounds of formula (Ia) that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases, or cholestatic diseases.

公开(公告)号：US20200000815A1

公开(公告)日：2020-01-02

申请号：US16481200

申请日：2018-01-29

申请人： Genfit

发明人： Jean-Francois Delhomel ,  Enrico Perspicace ,  Zouher Majd ,  Peggy Parroche ,  Robert Walczak ,  Pascal Bonnet ,  Jade Fogha

IPC分类号： A61K31/5377 ,  A61K31/192 ,  A61K31/40 ,  A61K31/428 ,  A61K31/427 ,  A61K31/54 ,  A61K31/5375 ,  A61K31/541 ,  A61K31/341 ,  C07D279/12 ,  C07D417/04 ,  C07D295/155 ,  C07D413/04 ,  C07D307/52

摘要： The present invention provides novel compounds of formula (Ia) that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases, or cholestatic diseases.

公开(公告)号：US11974997B2

公开(公告)日：2024-05-07

申请号：US17494458

申请日：2021-10-05

申请人： Genfit

发明人： Jean-Francois Delhomel ,  Enrico Perspicace ,  Zouher Majd ,  Peggy Parroche ,  Robert Walczak ,  Pascal Bonnet ,  Jade Fogha

IPC分类号： C07D405/14 ,  A61K31/192 ,  A61K31/40 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506

CPC分类号： A61K31/496 ,  A61K31/192 ,  A61K31/40 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/506 ,  C07D405/14

摘要： The present invention provides novel compounds that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases, or cholestatic diseases.