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1.发明申请公开(公告)号：US20090149548A1
公开(公告)日：2009-06-11
申请号：US12369595
申请日：2009-02-11
申请人： Genhui Chen , John Webster , Jianxiong Li , Wei Liu
发明人： Genhui Chen , John Webster , Jianxiong Li , Wei Liu
IPC分类号： A61K31/135 , A61K31/05 , C07C255/00 , C07C39/04
CPC分类号： C07D213/30 , C07C39/21 , C07C39/373 , C07C43/215 , C07C59/52 , C07C69/017 , C07C255/37 , C07D307/42 , C07D333/16
摘要： The invention provides novel 1,2-diphenylethene derivatives and pharmaceutically acceptable salts thereof, the process for production of these compounds and their pharmaceutical composition and the use of these compounds as modulators of T-cells, neutrophils, macrophages and their associated cytokines as agents for treating immune, inflammatory and auto-immune diseases.
摘要翻译： 本发明提供新的1,2-二苯乙烯衍生物及其药学上可接受的盐，这些化合物的制备方法及其药物组合物以及这些化合物作为T细胞，嗜中性粒细胞，巨噬细胞及其相关细胞因子调节剂的用途，作为 治疗免疫，炎症和自身免疫疾病。
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2.发明申请Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues 有权抗炎和牛皮癣治疗和蛋白激酶抑制由羟基芪和新颖的二苯乙烯衍生物和类似物公开(公告)号：US20050059733A1
公开(公告)日：2005-03-17
申请号：US10893863
申请日：2004-07-15
申请人： Genhui Chen , John Webster , Jianxiong Li , Kaji Hu , Wei Liu , Jiang Zhu
发明人： Genhui Chen , John Webster , Jianxiong Li , Kaji Hu , Wei Liu , Jiang Zhu
IPC分类号： A61K31/05 , A61K31/336 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , C07D303/14 , C07D303/16 , C07D303/22 , C07D405/04 , C07D303/12
CPC分类号： A61K31/047 , A61K9/0014 , A61K9/0019 , A61K31/05 , A61K31/336 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , C07D303/14 , C07D303/16 , C07D303/22 , C07D405/04
摘要： The present invention provides novel diphenyl ethene compounds and pharmaceutically-acceptable salts thereof. Also provided are methods for making the compounds of the invention as well as methods for the use thereof in the treatment of immune, inflammatory, and auto-immune diseases.
摘要翻译： 本发明提供新的二苯基乙烯化合物及其药学上可接受的盐。 还提供了制备本发明化合物的方法以及用于治疗免疫，炎症和自身免疫疾病的方法。
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公开(公告)号：US09051330B2
公开(公告)日：2015-06-09
申请号：US10509074
申请日：2003-03-18
申请人： Genhui Chen , Jianxiong Li , John Webster , Bin Li
发明人： Genhui Chen , Jianxiong Li , John Webster , Bin Li
IPC分类号： A61K31/407 , C07D495/04
CPC分类号： C07D495/04
摘要： The present invention provides novel dithiolopyrrolone compounds and their salts, which are useful as treatments for cancer and other proliferative diseases. The present invention also provides therapeutic compositions comprising particularly useful types of dithiolopyrrolones, the salts thereof, and methods of using the compounds within such types, particularly in treating proliferative diseases such as cancer.
摘要翻译： 本发明提供了新的二硫代环吡咯酮化合物及其盐，其可用作癌症和其它增殖性疾病的治疗。 本发明还提供包含特别有用类型的二硫代吡咯烷酮及其盐的治疗组合物，以及在这些类型中使用化合物，特别是治疗增殖性疾病如癌症的方法。
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4.发明授权Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues 有权抗炎和牛皮癣治疗和蛋白激酶抑制由羟基芪和新颖的二苯乙烯衍生物和类似物公开(公告)号：US07321050B2
公开(公告)日：2008-01-22
申请号：US10893863
申请日：2004-07-15
申请人： Genhui Chen , John M. Webster , Jianxiong Li , Kaji Hu , Wei Liu , Jiang Zhu
发明人： Genhui Chen , John M. Webster , Jianxiong Li , Kaji Hu , Wei Liu , Jiang Zhu
CPC分类号： A61K31/047 , A61K9/0014 , A61K9/0019 , A61K31/05 , A61K31/336 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , C07D303/14 , C07D303/16 , C07D303/22 , C07D405/04
摘要： The present invention provides novel diphenyl ethene compounds and pharmaceutically-acceptable salts thereof. Also provided are methods for making the compounds of the invention as well as methods for the use thereof in the treatment of immune, inflammatory, and auto-immune diseases.
摘要翻译： 本发明提供新的二苯基乙烯化合物及其药学上可接受的盐。 还提供了制备本发明化合物的方法以及用于治疗免疫，炎症和自身免疫疾病的方法。
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5.发明授权Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues 有权抗炎和牛皮癣治疗和蛋白激酶抑制由羟基芪和新颖的二苯乙烯衍生物和类似物公开(公告)号：US07868047B2
公开(公告)日：2011-01-11
申请号：US11949529
申请日：2007-12-03
申请人： Genhui Chen , John M. Webster , Jianxiong Li , Kaji Hu , Jiang Zhu , Wei Liu
发明人： Genhui Chen , John M. Webster , Jianxiong Li , Kaji Hu , Jiang Zhu , Wei Liu
IPC分类号： A01N31/08
CPC分类号： A61K31/047 , A61K9/0014 , A61K9/0019 , A61K31/05 , A61K31/336 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , C07D303/14 , C07D303/16 , C07D303/22 , C07D405/04
摘要： The present invention provides novel methods of treating psoriasis, protein tyrosine kinase-associated disorders, inflammation, epidermal hyperproliferation, diabetes, immune and autoimmune diseases, eczema, and inflammatory bowel disease, inhibiting protein kinase, neutrophil activation, cell proliferation, tumour growth, metastasis, and the development of atheromatous plaque and restonosis, controlling angiogenesis, and preventing inflammatory bowel disease, using hydroxystilbenes and novel stilbene derivatives.
摘要翻译： 本发明提供治疗牛皮癣，蛋白酪氨酸激酶相关疾病，炎症，表皮过度增生，糖尿病，免疫和自身免疫性疾病，湿疹和炎症性肠病，抑制蛋白激酶，嗜中性粒细胞活化，细胞增殖，肿瘤生长，转移的新方法 ，以及使用羟基茋和新颖的二苯乙烯衍生物的动脉粥样硬化斑块和再狭窄的发展，控制血管生成和预防炎症性肠病。
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6.发明申请ANTI-INFLAMMATORY AND PSORIASIS TREATMENT AND PROTEIN KINASE INHIBITION BY HYDROXY STILBENES AND NOVEL STILBENE DERIVATIVES AND ANALOGUES 审中-公开抗炎和抗原治疗和蛋白激酶抑制作用由羟基酪氨酸和新型酪氨酸衍生物和类似物公开(公告)号：US20100094041A1
公开(公告)日：2010-04-15
申请号：US12638618
申请日：2009-12-15
申请人： Genhui Chen , John M. Webster , Jianxiong Li , Kaji Hu , Wei Liu , Jiang Zhu
发明人： Genhui Chen , John M. Webster , Jianxiong Li , Kaji Hu , Wei Liu , Jiang Zhu
CPC分类号： A61K31/047 , A61K9/0014 , A61K9/0019 , A61K31/05 , A61K31/336 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , C07D303/14 , C07D303/16 , C07D303/22 , C07D405/04
摘要： The present invention provides pharmaceutical compositions containing hydroxystilbenes or their derivatives or analogues. The pharmaceutical compositions are useful for protein kinase inhibition, and for treatment of psoriasis, eczema and inflammation.
摘要翻译： 本发明提供含有羟基茋或其衍生物或类似物的药物组合物。 药物组合物可用于蛋白激酶抑制和治疗牛皮癣，湿疹和炎症。
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公开(公告)号：US20060074125A1
公开(公告)日：2006-04-06
申请号：US10509074
申请日：2003-03-18
申请人： Genhui Chen , Jianxiong Li , John Webster , Bin Li
发明人： Genhui Chen , Jianxiong Li , John Webster , Bin Li
IPC分类号： A61K31/407 , C07D498/02
CPC分类号： C07D495/04
摘要： The present invention provides novel dithiolopyrrolone compounds and their salts, which are useful as treatments for cancer and other proliferative diseases. The present invention also provides therapeutic compositions comprising particularly useful types of dithiolopyrrolones, the salts thereof, and methods of using the compounds within such types, particularly in treating proliferative diseases such as cancer.
摘要翻译： 本发明提供了新的二硫代环吡咯酮化合物及其盐，其可用作癌症和其它增殖性疾病的治疗。 本发明还提供包含特别有用类型的二硫代吡咯烷酮及其盐的治疗组合物，以及在这些类型中使用化合物，特别是治疗增殖性疾病如癌症的方法。
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8.发明申请Anti-Inflammatory and Psoriasis Treatment and Protein Kinase Inhibition by Hydroxy Stilbenes and Novel Stilbene Derivatives and Analogues 有权羟芪和新二萜烯衍生物及其类似物的抗炎和牛皮癣治疗和蛋白激酶抑制公开(公告)号：US20080139666A1
公开(公告)日：2008-06-12
申请号：US11949529
申请日：2007-12-03
申请人： Genhui Chen , John M. Webster , Jianxiong Li , Kaji Hu , Wei Liu , Jiang Zhu
发明人： Genhui Chen , John M. Webster , Jianxiong Li , Kaji Hu , Wei Liu , Jiang Zhu
IPC分类号： A61K31/047 , A61P17/06 , A61P43/00 , A61P35/00 , A61P37/00
CPC分类号： A61K31/047 , A61K9/0014 , A61K9/0019 , A61K31/05 , A61K31/336 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , C07D303/14 , C07D303/16 , C07D303/22 , C07D405/04
摘要： The present invention provides novel methods of treating psoriasis, protein tyrosine kinase-associated disorders, inflammation, epidermal hyperproliferation, diabetes, immune and autoimmune diseases, eczema, and inflammatory bowel disease, inhibiting protein kinase, neutrophil activation, cell proliferation, tumour growth, metastasis, and the development of atheromatous plaque and restonosis, controlling angiogenesis, and preventing inflammatory bowel disease, using hydroxystilbenes and novel stilbene derivatives.
摘要翻译： 本发明提供治疗牛皮癣，蛋白酪氨酸激酶相关疾病，炎症，表皮过度增生，糖尿病，免疫和自身免疫性疾病，湿疹和炎症性肠病，抑制蛋白激酶，嗜中性粒细胞活化，细胞增殖，肿瘤生长，转移的新方法 ，以及使用羟基茋和新颖的二苯乙烯衍生物的动脉粥样硬化斑块和再狭窄的发展，控制血管生成和预防炎症性肠病。
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公开(公告)号：US08487009B2
公开(公告)日：2013-07-16
申请号：US12369595
申请日：2009-02-11
申请人： Genhui Chen , John M. Webster , Jianxiong Li , Wei Liu
发明人： Genhui Chen , John M. Webster , Jianxiong Li , Wei Liu
IPC分类号： A01N31/14 , A61K31/075
CPC分类号： C07D213/30 , C07C39/21 , C07C39/373 , C07C43/215 , C07C59/52 , C07C69/017 , C07C255/37 , C07D307/42 , C07D333/16
摘要： The invention provides novel 1,2-diphenylethene derivatives and pharmaceutically acceptable salts thereof, the process for production of these compounds and their pharmaceutical composition and the use of these compounds as modulators of T-cells, neutrophils, macrophages and their associated cytokines as agents for treating immune, inflammatory and auto-immune diseases.
摘要翻译： 本发明提供新的1,2-二苯乙烯衍生物及其药学上可接受的盐，这些化合物的制备方法及其药物组合物以及这些化合物作为T细胞，嗜中性粒细胞，巨噬细胞及其相关细胞因子调节剂的用途，作为 治疗免疫，炎症和自身免疫疾病。
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10.发明授权Xenomins novel heterocyclic compounds with antimicrobial and antneoplastic properties 失效Xenomins新型杂环化合物具有抗菌和抗肿瘤性能
公开(公告)号：US5827872A
公开(公告)日：1998-10-27
申请号：US701834
申请日：1996-08-23
申请人： John M. Webster , Jianxiong Li , Genhui Chen
发明人： John M. Webster , Jianxiong Li , Genhui Chen
IPC分类号： C07D495/04 , A61K31/40 , C07D495/02
CPC分类号： C07D495/04
摘要： The invention is drawn to novel antibiotics, xenomins of the formula shown below, ##STR1## wherein R.sub.1 =hydrogen; R.sub.2 =an unsubstituted acyl group; R.sub.3 =hydrogen or alkyl, produced by Xenorhabdus species, the salts thereof, the compositions thereof and their use as medicaments and/or agrochemicals, particularly in the treatment of infectious diseases involving microorganisms susceptible to them, including drug-resistant Staphylococcus, and in the treatment of human and animal cancers.
摘要翻译： 本发明涉及新的抗生素，如下所示的结构式，其中R1 =氢; R2 =未取代的酰基; R3 =由Xenorhabdus物种产生的氢或烷基，其盐，其组合物及其作为药物和/或农用化学品的用途，特别是用于治疗涉及对其敏感的微生物（包括耐药性葡萄球菌）的感染性疾病，并且在 治疗人类和动物癌症。
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