公开(公告)号：US08986629B2

公开(公告)日：2015-03-24

申请号：US13777879

申请日：2013-02-26

Applicant: Genia Technologies, Inc.

Inventor： Kevin Deierling ,  Roger J. A. Chen ,  David J. Fullagar

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  C12Q1/68 ,  G01N33/487

CPC classification number: G01N27/4473 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/44782 ,  G01N27/44791 ,  G01N33/48721 ,  Y10T436/11 ,  C12Q2565/631 ,  C12Q2565/607

Abstract: A device for controlling, detecting, and measuring a molecular complex is disclosed. The device comprises a common electrode. The device further comprises a plurality of measurement cells. Each measurement cell includes a cell electrode and an integrator electronically coupled to the cell electrode. The integrator measures the current flowing between the common electrode and the cell electrode. The device further comprises a plurality of analog-to-digital converters, wherein an integrator from the plurality of measurement cells is electrically coupled to one analog-to-digital converter of the plurality of analog-to-digital converters.

Abstract translation: 公开了一种用于控制，检测和测量分子复合物的装置。 该装置包括公共电极。 该装置还包括多个测量单元。 每个测量单元包括电池耦合到电池电极的单元电极和积分器。 积分器测量在公共电极和电池电极之间流动的电流。 该装置还包括多个模数转换器，其中来自多个测量单元的积分器电耦合到多个模数转换器的一个模 - 数转换器。

公开(公告)号：US09290805B2

公开(公告)日：2016-03-22

申请号：US14591690

申请日：2015-01-07

Applicant: Genia Technologies, Inc.

Inventor： Kevin Deierling ,  Roger J. A. Chen ,  David J. Fullagar

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  C12Q1/68 ,  G01N33/487

CPC classification number: G01N27/4473 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/44782 ,  G01N27/44791 ,  G01N33/48721 ,  Y10T436/11 ,  C12Q2565/631 ,  C12Q2565/607

Abstract: A device for controlling, detecting, and measuring a molecular complex is disclosed. The device comprises a common electrode. The device further comprises a plurality of measurement cells. Each measurement cell includes a cell electrode and an integrator electronically coupled to the cell electrode. The integrator measures the current flowing between the common electrode and the cell electrode. The device further comprises a plurality of analog-to-digital converters, wherein an integrator from the plurality of measurement cells is electrically coupled to one analog-to-digital converter of the plurality of analog-to-digital converters.

公开(公告)号：US09494554B2

公开(公告)日：2016-11-15

申请号：US13918626

申请日：2013-06-14

Applicant: Genia Technologies, Inc.

Inventor： Randall Davis ,  Roger Chen ,  Arkadiusz Bibillo ,  Kevin Deierling

IPC: G01N27/447 ,  G01N33/487 ,  C12Q1/68

CPC classification number: G01N27/44791 ,  C12Q1/6869 ,  G01N33/48721 ,  C12Q2565/631

Abstract: The present disclosure provides devices, systems and methods for sequencing nucleic acid molecules. Nucleic acid molecules can be sequenced with a high accuracy (e.g., greater than 97% in a single pass) using a chip comprising an array of independently addressable nanopore sensors at a density of at least about 500 sites per 1 mm2. An individual nanopore sensor can include a nanopore in a membrane that is adjacent or in proximity to a sensing electrode.

Abstract translation: 本公开提供了用于测序核酸分子的装置，系统和方法。 使用包含独立可寻址的纳米孔传感器阵列的芯片，密度为每1mm 2至少约500个位点，核酸分子可以以高精度（例如，单次通过中大于97％）进行测序。 单个纳米孔传感器可以包括邻近或接近检测电极的膜中的纳米孔。

公开(公告)号：US20160266064A1

公开(公告)日：2016-09-15

申请号：US14977312

申请日：2015-12-21

Applicant: Genia Technologies, Inc.

Inventor： Kevin Deierling ,  Roger J.A. Chen ,  David J. Fullagar

IPC: G01N27/447 ,  C12Q1/68 ,  G01N33/487

Abstract: A device for controlling, detecting, and measuring a molecular complex is disclosed. The device comprises a common electrode. The device further comprises a plurality of measurement cells. Each measurement cell includes a cell electrode and an integrator electronically coupled to the cell electrode. The integrator measures the current flowing between the common electrode and the cell electrode. The device further comprises a plurality of analog-to-digital converters, wherein an integrator from the plurality of measurement cells is electrically coupled to one analog-to-digital converter of the plurality of analog-to-digital converters.

公开(公告)号：US20130237460A1

公开(公告)日：2013-09-12

申请号：US13777879

申请日：2013-02-26

Applicant: GENIA TECHNOLOGIES, INC.

Inventor： Kevin Deierling ,  Roger J.A. Chen ,  David J. Fullagar

IPC: C12Q1/68

CPC classification number: G01N27/4473 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/44782 ,  G01N27/44791 ,  G01N33/48721 ,  Y10T436/11 ,  C12Q2565/631 ,  C12Q2565/607

Abstract: A device for controlling, detecting, and measuring a molecular complex is disclosed. The device comprises a common electrode. The device further comprises a plurality of measurement cells. Each measurement cell includes a cell electrode and an integrator electronically coupled to the cell electrode. The integrator measures the current flowing between the common electrode and the cell electrode. The device further comprises a plurality of analog-to-digital converters, wherein an integrator from the plurality of measurement cells is electrically coupled to one analog-to-digital converter of the plurality of analog-to-digital converters.

公开(公告)号：US20190064107A1

公开(公告)日：2019-02-28

申请号：US16172488

申请日：2018-10-26

Applicant: Genia Technologies, Inc.

Inventor： Kevin Deierling ,  Roger J.A. Chen ,  David J. Fullagar

IPC: G01N27/447 ,  G01N33/487 ,  C12Q1/6874 ,  C12Q1/6869

Abstract: A device for controlling, detecting, and measuring a molecular complex is disclosed. The device comprises a common electrode. The device further comprises a plurality of measurement cells. Each measurement cell includes a cell electrode and an integrator electronically coupled to the cell electrode. The integrator measures the current flowing between the common electrode and the cell electrode. The device further comprises a plurality of analog-to-digital converters, wherein an integrator from the plurality of measurement cells is electrically coupled to one analog-to-digital converter of the plurality of analog-to-digital converters.

公开(公告)号：US20150211060A1

公开(公告)日：2015-07-30

申请号：US14591690

申请日：2015-01-07

Applicant: Genia Technologies, Inc.

Inventor： Kevin Deierling ,  Roger J.A. Chen ,  David J. Fullagar

IPC: C12Q1/68

CPC classification number: G01N27/4473 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/44782 ,  G01N27/44791 ,  G01N33/48721 ,  Y10T436/11 ,  C12Q2565/631 ,  C12Q2565/607

Abstract: A device for controlling, detecting, and measuring a molecular complex is disclosed. The device comprises a common electrode. The device further comprises a plurality of measurement cells. Each measurement cell includes a cell electrode and an integrator electronically coupled to the cell electrode. The integrator measures the current flowing between the common electrode and the cell electrode. The device further comprises a plurality of analog-to-digital converters, wherein an integrator from the plurality of measurement cells is electrically coupled to one analog-to-digital converter of the plurality of analog-to-digital converters.

Abstract translation: 公开了一种用于控制，检测和测量分子复合物的装置。 该装置包括公共电极。 该装置还包括多个测量单元。 每个测量单元包括电池耦合到电池电极的单元电极和积分器。 积分器测量在公共电极和电池电极之间流动的电流。 该装置还包括多个模数转换器，其中来自多个测量单元的积分器电耦合到多个模数转换器的一个模 - 数转换器。