公开(公告)号：US20250019731A1

公开(公告)日：2025-01-16

申请号：US18595947

申请日：2024-03-05

Applicant: Genomatica, Inc.

Inventor： Andreas W. SCHIRMER ,  Haibo WANG ,  Stephen B. DEL CARDAYRE ,  Zhihao HU ,  Louis G. HOM ,  Baolong ZHU ,  Cindy CHANG ,  Emanuela E. POPOVA

IPC: C12P7/6409 ,  C12N9/02 ,  C12N9/04 ,  C12N15/52 ,  C12N15/62 ,  C12P7/18 ,  C12P7/42 ,  C12P7/6436

Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

公开(公告)号：US20250101392A1

公开(公告)日：2025-03-27

申请号：US18662446

申请日：2024-05-13

Applicant: Genomatica, Inc.

Inventor： Andrew M. SHUMAKER ,  Bernardo M.T. DA COSTA ,  Kevin HOLDEN ,  Louis G. HOM ,  Tarah S. BARON ,  Noah HELMAN

IPC: C12N9/18 ,  C12N9/10 ,  C12P7/6436

Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.

公开(公告)号：US20210164002A1

公开(公告)日：2021-06-03

申请号：US17120586

申请日：2020-12-14

Applicant: Genomatica, Inc.

Inventor： Stephen B. DEL CARDAYRE ,  Louis G. HOM

IPC: C12P13/00 ,  C12N9/02 ,  C12N9/10 ,  C12N9/16 ,  C12N9/00 ,  C12N9/06

Abstract: The disclosure relates to recombinant microorganisms for the production of fatty amines and derivatives thereof. Further contemplated are cultured recombinant host cells as well as methods of producing fatty amines by employing these host cells.

公开(公告)号：US20250092355A1

公开(公告)日：2025-03-20

申请号：US18816019

申请日：2024-08-27

Applicant: Genomatica, Inc.

Inventor： Derek L. GREENFIELD ,  Louis G. HOM ,  Fernando A. SANCHEZ-RIERA ,  Zhihao HU ,  Vikranth ARLAGADDA ,  Eli S. GROBAN ,  Scott A. FRYKMAN

IPC: C12N1/20 ,  C07C31/125 ,  C07C33/02 ,  C07C53/126 ,  C07K14/195 ,  C07K14/24 ,  C07K14/245 ,  C07K14/255 ,  C07K14/26 ,  C12P7/6409

Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.

公开(公告)号：US20210371889A1

公开(公告)日：2021-12-02

申请号：US17350690

申请日：2021-06-17

Applicant: Genomatica, Inc.

Inventor： Derek L. GREENFIELD ,  Louis G. HOM ,  Fernando A. SANCHEZ-RIERA ,  Zhihao HU ,  Vikranth ARLAGADDA ,  Eli S. GROBAN ,  Scott A. FRYKMAN

IPC: C12P7/64 ,  C07K14/245 ,  C07K14/195 ,  C07C31/125 ,  C07C33/02 ,  C07C53/126

Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.

公开(公告)号：US20210309979A1

公开(公告)日：2021-10-07

申请号：US17116817

申请日：2020-12-09

Applicant: Genomatica, Inc.

Inventor： Andrew M. SHUMAKER ,  Bernardo M. DA COSTA ,  Kevin HOLDEN ,  Louis G. HOM ,  Tarah S. BARON ,  Noah HELMAN

IPC: C12N9/18 ,  C12N9/10 ,  C12P7/64

Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.