公开(公告)号：US11142756B2

公开(公告)日：2021-10-12

申请号：US16802133

申请日：2020-02-26

Applicant: Genomatica, Inc.

Inventor： Derek L. Greenfield ,  Donald E. Trimbur ,  Andreas W. Schirmer ,  Cindy Chang ,  Behnaz Behrouzian ,  Jessica Winger

IPC: C12N15/63 ,  C12N15/70 ,  C12N9/88 ,  C12N1/21 ,  C07K14/245 ,  C12P7/64 ,  C12N9/00 ,  C12N15/67

Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.

公开(公告)号：US11339384B2

公开(公告)日：2022-05-24

申请号：US16500188

申请日：2018-04-03

Applicant: Genomatica, Inc.

Inventor： Angelica Zabala Bautista ,  Min Sun Park ,  Alma Itzel Ramos-Solis ,  Bernardo Moura Torres Da Costa ,  Behnaz Behrouzian ,  Donald E. Trimbur ,  Emanuela Popova ,  Qijun Hu ,  Stephen Bralley Del Cardayre

IPC: C12N9/16 ,  C12P7/6409

Abstract: The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.

公开(公告)号：US12157904B2

公开(公告)日：2024-12-03

申请号：US17715587

申请日：2022-04-07

Applicant: Genomatica, Inc.

Inventor： Angelica Zabala Bautista ,  Min Sun Park ,  Alma Itzel Ramos-Solis ,  Bernardo Moura Torres Da Costa ,  Behnaz Behrouzian ,  Donald E. Trimbur ,  Emanuela Popova ,  Qijun Hu ,  Stephen Bralley Del Cardayre

IPC: C12N9/16 ,  C12P7/6409 ,  C12P7/6436

Abstract: The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.