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公开(公告)号：US11060099B2
公开(公告)日：2021-07-13
申请号：US15650285
申请日：2017-07-14
Applicant: Genomatica, Inc.
Inventor： Derek L. Greenfield , Andreas W. Schirmer , Elizabeth J. Clarke , Eli S. Groban , Bernardo M. Da Costa , Zhihao Hu , Kevin Holden , Noah Helman
IPC: C12N1/21 , C12P7/64 , C07K14/195 , C07K14/245 , C12N9/16 , C12N15/70 , C12N9/04 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/88 , C12N9/90 , C12N9/00 , C12P7/04
Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.
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公开(公告)号：US11142756B2
公开(公告)日：2021-10-12
申请号：US16802133
申请日：2020-02-26
Applicant: Genomatica, Inc.
Inventor： Derek L. Greenfield , Donald E. Trimbur , Andreas W. Schirmer , Cindy Chang , Behnaz Behrouzian , Jessica Winger
Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.
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公开(公告)号：US11034937B2
公开(公告)日：2021-06-15
申请号：US16414550
申请日：2019-05-16
Applicant: Genomatica, Inc.
Inventor： Derek L. Greenfield , Elizabeth J. Clarke , Eli S. Groban , Vikranth Arlagadda , Sungwon Lee , Xuezhi Li , Zhihao Hu , Baolong Zhu
Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
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