公开(公告)号：US11142756B2

公开(公告)日：2021-10-12

申请号：US16802133

申请日：2020-02-26

Applicant: Genomatica, Inc.

Inventor： Derek L. Greenfield ,  Donald E. Trimbur ,  Andreas W. Schirmer ,  Cindy Chang ,  Behnaz Behrouzian ,  Jessica Winger

IPC: C12N15/63 ,  C12N15/70 ,  C12N9/88 ,  C12N1/21 ,  C07K14/245 ,  C12P7/64 ,  C12N9/00 ,  C12N15/67

Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.