公开(公告)号：US20240309405A1

公开(公告)日：2024-09-19

申请号：US18339397

申请日：2023-06-22

Applicant: Genomatica, Inc.

Inventor： Andreas W. SCHIRMER ,  Risha Lindig Bond ,  Erin Frances Perry

IPC: C12P7/18 ,  C07C68/00 ,  C07C69/22 ,  C07C69/30 ,  C12N15/52

CPC classification number: C12P7/18 ,  C07C68/00 ,  C07C69/22 ,  C07C69/30 ,  C12N15/52

Abstract: The disclosure relates to the field of specialty chemicals and methods for their synthesis. In embodiments, the disclosure provides novel multifunctional fatty acid derivative molecules such as e.g., fatty triols, fatty tetrols, dihydroxy fatty acids, etc. The disclosure further provides derivatives of the disclosed multifunctional molecules which are useful e.g., in the production of personal care products, surfactants, detergents, polymers, paints, coatings, and as emulsifiers, emollients, and thickeners in cosmetics and foods, as industrial solvents and plasticizers, etc. The disclosure further provides biochemical pathways, recombinant microorganisms and methods for the biological production of various multifuctional fatty acid derivatives.

公开(公告)号：US12221644B2

公开(公告)日：2025-02-11

申请号：US17271439

申请日：2019-08-28

Applicant: Genomatica, Inc.

Inventor： Andreas W. Schirmer ,  Katherine Ann Murphy ,  Erin Frances Perry

IPC: C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/16 ,  C12N9/88 ,  C12P7/6418 ,  C12P7/6481

Abstract: The disclosure relates to the field of specialty chemicals and methods for their synthesis. In embodiments, the disclosure provides viable bacterial cells which comprise heterologous dual 3-hydroxy-acyl-ACP dehydratase/isomerases, etc. The disclosure further provides monounsaturated fatty acid derivative molecules produced by the viable bacterial cells which are non-native to the bacterial cells. The disclosure further provides methods for the preparation and production of non-native monounsaturated fatty acid derivative molecules such as e.g., an ω3-monounsaturated fatty acid derivative, an ω5-monounsaturated fatty acid derivative, an ω9-monounsaturated fatty acid derivative, an ω11-monounsaturated fatty acid fatty acid derivative, etc.