公开(公告)号：US10065949B2

公开(公告)日：2018-09-04

申请号：US15593440

申请日：2017-05-12

申请人： Genzyme Corporation

发明人： Craig S. Siegel ,  Rayomand Gimi ,  Michael Reardon ,  Jin Zhao

IPC分类号： C07D453/00 ,  C07D453/02 ,  C07D417/12 ,  C07D417/06 ,  C07D277/30

摘要： The invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

公开(公告)号：US09518049B2

公开(公告)日：2016-12-13

申请号：US14776432

申请日：2014-03-14

申请人： Genzyme Corporation

发明人： Craig S. Siegel ,  Jin Zhao

IPC分类号： C07D453/00 ,  C07C59/245

CPC分类号： C07D453/00 ,  C07C59/245

摘要： The present invention relates to novel salt forms of (S)-Quinuclidin-3-yl (2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-yl)carbamate useful as an inhibitor of glucosylceramide synthase (GCS) and for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

摘要翻译： 本发明涉及可用作葡萄糖神经酰胺合酶抑制剂的（S） - 奎宁环-3-基（2-（2-（2-（4-氟苯基）噻唑-4-基）丙-2-基）氨基甲酸酯的新型盐形式 GCS）和用于治疗代谢疾病如溶酶体贮积病，单独或与酶替代疗法组合，以及治疗癌症。

公开(公告)号：US20190031652A1

公开(公告)日：2019-01-31

申请号：US16051892

申请日：2018-08-01

申请人： Genzyme Corporation

发明人： Craig S. Siegel ,  Rayomand Gimi ,  Michael Reardon ,  Jin Zhao

IPC分类号： C07D453/02 ,  C07D417/12 ,  C07D417/06 ,  C07D277/30

摘要： The invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

公开(公告)号：US09682975B2

公开(公告)日：2017-06-20

申请号：US14776443

申请日：2014-03-13

申请人： Genzyme Corporation

发明人： Craig S. Siegel ,  Rayomand Gimi ,  Michael Reardon ,  Jin Zhao

IPC分类号： C07D453/00 ,  C07D453/02 ,  C07D417/06 ,  C07D277/30 ,  C07D417/12

CPC分类号： C07D453/02 ,  C07D277/30 ,  C07D417/06 ,  C07D417/12

摘要： The invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

公开(公告)号：US10954230B2

公开(公告)日：2021-03-23

申请号：US16791854

申请日：2020-02-14

申请人： GENZYME CORPORATION

发明人： Craig S. Siegel ,  Rayomand Gimi ,  Michael Reardon ,  Jin Zhao

IPC分类号： C07D453/02 ,  C07D417/06 ,  C07D417/12 ,  C07D277/30

摘要： This invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

公开(公告)号：US10604518B2

公开(公告)日：2020-03-31

申请号：US16051892

申请日：2018-08-01

申请人： Genzyme Corporation

发明人： Craig S. Siegel ,  Rayomand Gimi ,  Michael Reardon ,  Jin Zhao

IPC分类号： C07D453/00 ,  C07D453/02 ,  C07D417/06 ,  C07D277/30 ,  C07D417/12

摘要： The invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.