公开(公告)号：US12123880B2

公开(公告)日：2024-10-22

申请号：US18321542

申请日：2023-05-22

Applicant: Genzyme Corporation

Inventor： Xiaoying Jin ,  Catherine O'Riordan ,  Lin Liu ,  Kate Zhang

IPC: G01N33/68 ,  C12N15/86 ,  G01N30/72 ,  G01N30/02

CPC classification number: G01N33/6848 ,  C12N15/86 ,  G01N30/72 ,  C12N2750/14123 ,  C12N2750/14143 ,  G01N2030/027

Abstract: Provided herein are methods for determining the serotype of a virus particle and/or or determining the heterogeneity of a virus particle (e.g., an AAV particle). In other embodiments, the invention provides methods to determine the heterogeneity of AAV particles. In some aspects, the invention provides viral particles (e.g., rAAV particles) with improved stability and/or improved transduction efficiency by increasing the acetylation and/or deamidation of capsid proteins.

公开(公告)号：US12298313B1

公开(公告)日：2025-05-13

申请号：US19013863

申请日：2025-01-08

Applicant: Genzyme Corporation

Inventor： Xiaoying Jin ,  Catherine O'Riordan ,  Lin Liu ,  Kate Zhang

IPC: G01N33/68 ,  C12N15/86 ,  G01N30/72 ,  G01N30/02

Abstract: Provided herein are methods for determining the serotype of a virus particle and/or or determining the heterogeneity of a virus particle (e.g., an AAV particle). In other embodiments, the invention provides methods to determine the heterogeneity of AAV particles. In some aspects, the invention provides viral particles (e.g., rAAV particles) with improved stability and/or improved transduction efficiency by increasing the acetylation and/or deamidation of capsid proteins.

公开(公告)号：US20250027951A1

公开(公告)日：2025-01-23

申请号：US18801293

申请日：2024-08-12

Applicant: Genzyme Corporation

Inventor： Xiaoying JIN ,  Catherine O'Riordan ,  Lin Liu ,  Kate Zhang

IPC: G01N33/68 ,  C12N15/86 ,  G01N30/02 ,  G01N30/72

Abstract: Provided herein are methods for determining the serotype of a virus particle and/or or determining the heterogeneity of a virus particle (e.g., an AAV particle). In other embodiments, the invention provides methods to determine the heterogeneity of AAV particles. In some aspects, the invention provides viral particles (e.g., rAAV particles) with improved stability and/or improved transduction efficiency by increasing the acetylation and/or deamidation of capsid proteins.

公开(公告)号：US11698377B2

公开(公告)日：2023-07-11

申请号：US16325653

申请日：2017-08-14

Applicant: Genzyme Corporation

Inventor： Xiaoying Jin ,  Catherine O'Riordan ,  Lin Liu ,  Kate Zhang

IPC: G01N33/68 ,  C12N15/86 ,  G01N30/72 ,  G01N30/02

CPC classification number: G01N33/6848 ,  C12N15/86 ,  G01N30/72 ,  C12N2750/14123 ,  C12N2750/14143 ,  G01N2030/027

Abstract: Provided herein are methods for determining the serotype of a virus particle and/or or determining the heterogeneity of a virus particle (e.g., an AAV particle). In other embodiments, the invention provides methods to determine the heterogeneity of AAV particles. In some aspects, the invention provides viral particles (e.g., rAAV particles) with improved stability and/or improved transduction efficiency by increasing the acetylation and/or deamidation of capsid proteins.