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公开(公告)号：US12110338B2
公开(公告)日：2024-10-08
申请号：US17404412
申请日：2021-08-17
申请人： Genzyme Corporation
发明人： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
CPC分类号： C07K16/2893 , A61K47/549 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07K16/28 , C07K16/2809 , C07K16/2851 , C07K16/32 , C07K16/40 , C07K2317/40 , C07K2317/41 , C07K2317/522 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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公开(公告)号：US20170267774A1
公开(公告)日：2017-09-21
申请号：US15417648
申请日：2017-01-27
申请人： Genzyme Corporation
发明人： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
CPC分类号： C07K16/2893 , A61K47/549 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07K16/28 , C07K16/2809 , C07K16/2851 , C07K16/32 , C07K16/40 , C07K2317/40 , C07K2317/41 , C07K2317/522 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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公开(公告)号：US10214589B2
公开(公告)日：2019-02-26
申请号：US15417648
申请日：2017-01-27
申请人： Genzyme Corporation
发明人： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
摘要： The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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公开(公告)号：US20220089763A1
公开(公告)日：2022-03-24
申请号：US17404412
申请日：2021-08-17
申请人： Genzyme Corporation
发明人： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
摘要： The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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公开(公告)号：US11130816B2
公开(公告)日：2021-09-28
申请号：US16238932
申请日：2019-01-03
申请人： Genzyme Corporation
发明人： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
摘要： The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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公开(公告)号：US20190233531A1
公开(公告)日：2019-08-01
申请号：US16238932
申请日：2019-01-03
申请人： Genzyme Corporation
发明人： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
CPC分类号： A61K47/549 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07K16/28 , C07K16/2809 , C07K16/2851 , C07K16/2893 , C07K16/32 , C07K16/40 , C07K2317/40 , C07K2317/41 , C07K2317/522 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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公开(公告)号：US09580511B2
公开(公告)日：2017-02-28
申请号：US14203479
申请日：2014-03-10
申请人： Genzyme Corporation
发明人： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
CPC分类号： C07K16/2893 , A61K47/48092 , A61K47/48384 , A61K47/48638 , A61K47/48715 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07K16/28 , C07K16/2809 , C07K16/2851 , C07K16/32 , C07K16/40 , C07K2317/40 , C07K2317/41 , C07K2317/522 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
摘要翻译： 本公开提供结合多肽（例如抗体）及其效应子部分缀合物（例如，抗体 - 药物偶联物或ADC），其包含在结合多肽的天然或工程化聚糖中的位点特异性改造的药物 - 聚糖键。 本公开还提供了编码抗原结合多肽的核酸，用于制备这种抗原结合多肽的重组表达载体和宿主细胞。 还提供了使用本文公开的抗原结合多肽治疗疾病的方法。
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