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公开(公告)号：US20250066497A1
公开(公告)日：2025-02-27
申请号：US18787702
申请日：2024-07-29
Applicant: Genzyme Corporation
Inventor： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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公开(公告)号：US12110338B2
公开(公告)日：2024-10-08
申请号：US17404412
申请日：2021-08-17
Applicant: Genzyme Corporation
Inventor： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
CPC classification number: C07K16/2893 , A61K47/549 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07K16/28 , C07K16/2809 , C07K16/2851 , C07K16/32 , C07K16/40 , C07K2317/40 , C07K2317/41 , C07K2317/522 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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公开(公告)号：US20170267774A1
公开(公告)日：2017-09-21
申请号：US15417648
申请日：2017-01-27
Applicant: Genzyme Corporation
Inventor： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
CPC classification number: C07K16/2893 , A61K47/549 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07K16/28 , C07K16/2809 , C07K16/2851 , C07K16/32 , C07K16/40 , C07K2317/40 , C07K2317/41 , C07K2317/522 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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公开(公告)号：US11807690B2
公开(公告)日：2023-11-07
申请号：US16655500
申请日：2019-10-17
Applicant: Genzyme Corporation
Inventor： Clark Pan , Huawei Qiu , Pradeep Dhal , Bo Chen , Diego Gianolio
CPC classification number: C07K16/2893 , A61K47/549 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07K16/28 , C07K16/2809 , C07K16/2851 , C07K16/32 , C07K16/40 , C07K2317/40 , C07K2317/41 , C07K2317/522 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
Abstract: Provided are binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof, comprising a CH1 domain (e.g., a human IgG1 CH1 domain), wherein the CH1 domain has an engineered N-linked glycosylation site at amino acid position 114, according to Kabat numbering. Also provided are nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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公开(公告)号：US20220089763A1
公开(公告)日：2022-03-24
申请号：US17404412
申请日：2021-08-17
Applicant: Genzyme Corporation
Inventor： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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Patent Agency Ranking
公开(公告)号：US11130816B2
公开(公告)日：2021-09-28
申请号：US16238932
申请日：2019-01-03
Applicant: Genzyme Corporation
Inventor： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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公开(公告)号：US10113032B2
公开(公告)日：2018-10-30
申请号：US15079887
申请日：2016-03-24
Applicant: GENZYME CORPORATION
Inventor： Pradeep Dhal , Kanwen Yang , Robert J. Miller , Stephen Randall Holmes-Farley
IPC: C08G69/26 , A61K31/787 , C08G63/672 , C08G73/02 , C08G73/06 , C07D211/14 , C07D211/16 , A61K47/60 , A61K47/54
Abstract: Amine functional polyamides comprise amine and ammonium groups along the polymer chain. Amine functional polyamides can be used as pharmaceutical agents and in pharmaceutical compositions. The amine functional polyamides are particularly useful in the treatment or prevention of mucositis and infection, specifically oral mucositis, surgical site infection, and lung infection associated with cystic fibrosis.
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公开(公告)号：US20190233531A1
公开(公告)日：2019-08-01
申请号：US16238932
申请日：2019-01-03
Applicant: Genzyme Corporation
Inventor： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
CPC classification number: A61K47/549 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07K16/28 , C07K16/2809 , C07K16/2851 , C07K16/2893 , C07K16/32 , C07K16/40 , C07K2317/40 , C07K2317/41 , C07K2317/522 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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公开(公告)号：US09701753B2
公开(公告)日：2017-07-11
申请号：US14203438
申请日：2014-03-10
Applicant: Genzyme Corporation
Inventor： Clark Pan , Huawei Qiu , Pradeep Dhal , Bo Chen , Diego Gianolio
CPC classification number: C07K16/2893 , A61K47/48092 , A61K47/48384 , A61K47/48638 , A61K47/48715 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07K16/28 , C07K16/2809 , C07K16/2851 , C07K16/32 , C07K16/40 , C07K2317/40 , C07K2317/41 , C07K2317/522 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
Abstract: Provided are binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof, comprising a CH1 domain (e.g., a human IgG1 CH1 domain), wherein the CH1 domain has an engineered N-linked glycosylation site at amino acid position 114, according to Kabat numbering. Also provided are nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
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公开(公告)号：US09580511B2
公开(公告)日：2017-02-28
申请号：US14203479
申请日：2014-03-10
Applicant: Genzyme Corporation
Inventor： Clark Pan , Qun Zhou , James Stefano , Pradeep Dhal , Bo Chen , Diego Gianolio , Robert Miller , Huawei Qiu
CPC classification number: C07K16/2893 , A61K47/48092 , A61K47/48384 , A61K47/48638 , A61K47/48715 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07K16/28 , C07K16/2809 , C07K16/2851 , C07K16/32 , C07K16/40 , C07K2317/40 , C07K2317/41 , C07K2317/522 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
Abstract translation: 本公开提供结合多肽（例如抗体）及其效应子部分缀合物（例如，抗体 - 药物偶联物或ADC），其包含在结合多肽的天然或工程化聚糖中的位点特异性改造的药物 - 聚糖键。 本公开还提供了编码抗原结合多肽的核酸，用于制备这种抗原结合多肽的重组表达载体和宿主细胞。 还提供了使用本文公开的抗原结合多肽治疗疾病的方法。
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